ENSMUSG00000009907


Mus musculus

Features
Gene ID: ENSMUSG00000009907
  
Biological name :Vps4b
  
Synonyms : P46467 / vacuolar protein sorting 4B / Vps4b
  
Possible biological names infered from orthology : O75351 / vacuolar protein sorting 4 homolog B
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E2.1
Gene start: 106764071
Gene end: 106796728
  
Corresponding Affymetrix probe sets: 10357064 (MoGene1.0st)   10417757 (MoGene1.0st)   1417007_a_at (Mouse Genome 430 2.0 Array)   1457067_at (Mouse Genome 430 2.0 Array)   1460104_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000092230
Ensembl peptide - ENSMUSP00000108356
NCBI entrez gene - 20479     See in Manteia.
MGI - MGI:1100499
RefSeq - NM_009190
RefSeq Peptide - NP_033216
swissprot - P46467
swissprot - Q3TN07
Ensembl - ENSMUSG00000009907
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-185p13.1ENSDARG00000095837Danio rerio
 VPS4BENSGALG00000012879Gallus gallus
 VPS4BENSG00000119541Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vps4a / Q8VEJ9 / vacuolar protein sorting 4A / Q9UN37* / AC026464.4* / vacuolar protein sorting 4 homolog A*ENSMUSG0000003191380
Q8K0T4 / Katnal1 / Katanin p60 ATPase-containing subunit A-like 1 / Q9BW62* / katanin catalytic subunit A1 like 1*ENSMUSG0000004129836
Katna1 / katanin catalytic subunit A1 / O75449*ENSMUSG0000001979435
Q9D3R6 / Katnal2 / Katanin p60 ATPase-containing subunit A-like 2 / Q8IYT4* / katanin catalytic subunit A1 like 2*ENSMUSG0000002542025
Gm42791 / Q9BW62* / KATNAL1* / katanin catalytic subunit A1 like 1*ENSMUSG000001068926


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR007330  MIT
 IPR015415  Vps4 oligomerisation, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036181  MIT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000920 cell separation after cytokinesis IEA
 biological_processGO:0006813 potassium ion transport IDA
 biological_processGO:0006997 nucleus organization IEA
 biological_processGO:0007032 endosome organization IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007080 mitotic metaphase plate congression IEA
 biological_processGO:0010824 regulation of centrosome duplication IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016197 endosomal transport IEA
 biological_processGO:0019076 viral release from host cell IEA
 biological_processGO:0030301 cholesterol transport IMP
 biological_processGO:0032510 endosome to lysosome transport via multivesicular body sorting pathway IEA
 biological_processGO:0033993 response to lipid IEA
 biological_processGO:0036258 multivesicular body assembly IMP
 biological_processGO:0039702 viral budding via host ESCRT complex IEA
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
 biological_processGO:0048524 positive regulation of viral process IMP
 biological_processGO:0050792 regulation of viral process IEA
 biological_processGO:0051261 protein depolymerization IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0061738 late endosomal microautophagy IMP
 biological_processGO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway IEA
 biological_processGO:1901673 regulation of mitotic spindle assembly IEA
 biological_processGO:1902188 positive regulation of viral release from host cell IEA
 biological_processGO:1903542 negative regulation of exosomal secretion IEA
 biological_processGO:1903543 positive regulation of exosomal secretion IEA
 biological_processGO:1903724 positive regulation of centriole elongation IEA
 biological_processGO:1903902 positive regulation of viral life cycle IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0090543 Flemming body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042623 ATPase activity, coupled IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019868 Vta1 / Q9CR26 / vesicle (multivesicular body) trafficking 1 / Q9NP79* / vesicle trafficking 1*  / complex
 ENSMUSG00000028419 Chmp5 / Q9D7S9 / Charged multivesicular body protein 5 / Q9NZZ3*  / complex
 ENSMUSG00000031913 Vps4a / Q8VEJ9 / vacuolar protein sorting 4A / Q9UN37* / AC026464.4* / vacuolar protein sorting 4 homolog A*  / complex






 

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