ENSMUSG00000041773


Mus musculus

Features
Gene ID: ENSMUSG00000041773
  
Biological name :Enc1
  
Synonyms : Ectoderm-neural cortex protein 1 / Enc1 / O35709
  
Possible biological names infered from orthology : ectodermal-neural cortex 1 / O14682
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: D1
Gene start: 97241105
Gene end: 97253034
  
Corresponding Affymetrix probe sets: 10406817 (MoGene1.0st)   1420964_at (Mouse Genome 430 2.0 Array)   1420965_a_at (Mouse Genome 430 2.0 Array)   1450061_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038783
NCBI entrez gene - 13803     See in Manteia.
MGI - MGI:109610
RefSeq - NM_007930
RefSeq Peptide - NP_031956
swissprot - O35709
Ensembl - ENSMUSG00000041773
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 enc1ENSDARG00000035398Danio rerio
 ENC1ENSGALG00000014930Gallus gallus
 ENC1ENSG00000171617Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klhl25 / Q8R2P1 / Kelch-like protein 25 / Q9H0H3* / kelch like family member 25*ENSMUSG0000005565273
Klhl24 / Q8BRG6 / Kelch-like protein 24 / Q6TFL4* / kelch like family member 24*ENSMUSG0000006290131
Klhl21 / Q3U410 / Kelch-like protein 21 / Q9UJP4* / kelch like family member 21*ENSMUSG0000007370029
Klhl6 / Q6V595 / Kelch-like protein 6 / Q8WZ60* / kelch like family member 6*ENSMUSG0000004300829
Klhl29 / Q80T74 / Kelch-like protein 29 / Q96CT2* / kelch like family member 29*ENSMUSG0000002062728
Klhl35 / Q9CZ49 / Kelch-like protein 35 / Q6PF15* / kelch like family member 35*ENSMUSG0000003529828
Klhl30 / Q8C3F7 / Kelch-like protein 30 / Q0D2K2* / kelch like family member 30*ENSMUSG0000002630827
Klhl38 / Q8BSF5 / Kelch-like protein 38 / Q2WGJ6* / kelch like family member 38*ENSMUSG0000002235727
Klhl23 / Q6GQU2 / Kelch-like protein 23 / Q8NBE8* / kelch like family member 23*ENSMUSG0000004215526
Kbtbd3 / Q8BHI4 / Kelch repeat and BTB domain-containing protein 3 / Q8NAB2* / kelch repeat and BTB domain containing 3*ENSMUSG0000002589324
A2AUC9 / Klhl41 / Kelch-like protein 41 / O60662* / kelch like family member 41*ENSMUSG0000007530723
Kbtbd2 / kelch repeat and BTB domain containing 2 / Q8IY47*ENSMUSG0000005948623
Klhl40 / kelch like family member 40 / Q2TBA0*ENSMUSG0000007400123
Kbtbd7 / Q86V97* / Q8WVZ9* / KBTBD6* / kelch repeat and BTB domain containing 6* / kelch repeat and BTB domain containing 7*ENSMUSG0000004388122
Kbtbd8 / Q3UQV5 / Kelch repeat and BTB domain-containing protein 8 / Q8NFY9* / kelch repeat and BTB domain containing 8*ENSMUSG0000003003122
Q9D618 / Kbtbd12 / Kelch repeat and BTB domain-containing protein 12 / Q3ZCT8* / kelch repeat and BTB domain containing 12*ENSMUSG0000003318219
Kbtbd6 / uncharacterized protein LOC432879 / Q86V97* / Q8WVZ9* / KBTBD7* / kelch repeat and BTB domain containing 6* / kelch repeat and BTB domain containing 7*ENSMUSG0000007550217


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR006652  Kelch repeat type 1
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated
 IPR015915  Kelch-type beta propeller
 IPR017096  BTB-kelch protein
 IPR030562  Ectoderm-neural cortex protein 1
 IPR037293  Galactose oxidase, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010499 proteasomal ubiquitin-independent protein catabolic process IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0017148 negative regulation of translation IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0010168 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0013764 decreased T-helper cell number "reduction in the number of an effector T cell that provides help in the form of secreted cytokines to other immune cells" [CL:0000912]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr