ENSMUSG00000075307


Mus musculus

Features
Gene ID: ENSMUSG00000075307
  
Biological name :Klhl41
  
Synonyms : A2AUC9 / Kelch-like protein 41 / Klhl41
  
Possible biological names infered from orthology : kelch like family member 41 / O60662
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C2
Gene start: 69670120
Gene end: 69684230
  
Corresponding Affymetrix probe sets: 10472562 (MoGene1.0st)   1444494_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097627
NCBI entrez gene - 228003     See in Manteia.
MGI - MGI:2683854
RefSeq - NM_001081087
RefSeq Peptide - NP_001074556
swissprot - A2AUC9
Ensembl - ENSMUSG00000075307
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 E9QIN8ENSDARG00000068888Danio rerio
 F1QEG2ENSDARG00000006757Danio rerio
 KLHL41ENSGALG00000038813Gallus gallus
 KLHL41ENSG00000239474Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klhl40 / kelch like family member 40 / Q2TBA0*ENSMUSG0000007400152
Kbtbd2 / kelch repeat and BTB domain containing 2 / Q8IY47*ENSMUSG0000005948624
Klhl25 / Q8R2P1 / Kelch-like protein 25 / Q9H0H3* / kelch like family member 25*ENSMUSG0000005565224
Kbtbd8 / Q3UQV5 / Kelch repeat and BTB domain-containing protein 8 / Q8NFY9* / kelch repeat and BTB domain containing 8*ENSMUSG0000003003123
Klhl24 / Q8BRG6 / Kelch-like protein 24 / Q6TFL4* / kelch like family member 24*ENSMUSG0000006290123
Klhl38 / Q8BSF5 / Kelch-like protein 38 / Q2WGJ6* / kelch like family member 38*ENSMUSG0000002235723
Klhl30 / Q8C3F7 / Kelch-like protein 30 / Q0D2K2* / kelch like family member 30*ENSMUSG0000002630822
Klhl29 / Q80T74 / Kelch-like protein 29 / Q96CT2* / kelch like family member 29*ENSMUSG0000002062722
Enc1 / O35709 / Ectoderm-neural cortex protein 1 / O14682* / ectodermal-neural cortex 1*ENSMUSG0000004177322
Klhl6 / Q6V595 / Kelch-like protein 6 / Q8WZ60* / kelch like family member 6*ENSMUSG0000004300822
Klhl35 / Q9CZ49 / Kelch-like protein 35 / Q6PF15* / kelch like family member 35*ENSMUSG0000003529821
Klhl21 / Q3U410 / Kelch-like protein 21 / Q9UJP4* / kelch like family member 21*ENSMUSG0000007370021
Q9D618 / Kbtbd12 / Kelch repeat and BTB domain-containing protein 12 / Q3ZCT8* / kelch repeat and BTB domain containing 12*ENSMUSG0000003318221
Kbtbd7 / Q86V97* / Q8WVZ9* / KBTBD6* / kelch repeat and BTB domain containing 6* / kelch repeat and BTB domain containing 7*ENSMUSG0000004388119
Klhl23 / Q6GQU2 / Kelch-like protein 23 / Q8NBE8* / kelch like family member 23*ENSMUSG0000004215519
Kbtbd3 / Q8BHI4 / Kelch repeat and BTB domain-containing protein 3 / Q8NAB2* / kelch repeat and BTB domain containing 3*ENSMUSG0000002589318
Kbtbd6 / uncharacterized protein LOC432879 / Q86V97* / Q8WVZ9* / KBTBD7* / kelch repeat and BTB domain containing 6* / kelch repeat and BTB domain containing 7*ENSMUSG0000007550216


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR006652  Kelch repeat type 1
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated
 IPR015915  Kelch-type beta propeller
 IPR017096  BTB-kelch protein
 IPR030571  Kelch-like protein 41


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030239 myofibril assembly IMP
 biological_processGO:0031275 regulation of lateral pseudopodium assembly IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IDA
 biological_processGO:0045214 sarcomere organization IBA
 biological_processGO:0045661 regulation of myoblast differentiation IMP
 biological_processGO:0048741 skeletal muscle fiber development IBA
 biological_processGO:2000291 regulation of myoblast proliferation IMP
 biological_processGO:2001014 regulation of skeletal muscle cell differentiation IMP
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0031143 pseudopodium IEA
 cellular_componentGO:0031430 M band IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IEA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Sox1tm1(cre)Take/Sox1+
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Sox1tm1(cre)Take/Sox1+
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Sox1tm1(cre)Take/Sox1+
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Sox1tm1(cre)Take/Sox1+
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Sox1tm1(cre)Take/Sox1+
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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