Manteia - Molecule gene

ENSMUSG00000059486

Mus musculus

Features

Gene ID:	ENSMUSG00000059486

Biological name :	Kbtbd2

Synonyms :	Kbtbd2 / kelch repeat and BTB domain containing 2

Possible biological names infered from orthology :	Q8IY47

Species:	Mus musculus

Chr. number:	6
Strand:	-1
Band:	B3
Gene start:	56777524
Gene end:	56797813

Corresponding Affymetrix probe sets:	10544976 (MoGene1.0st) 1451214_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000109960 Ensembl peptide - ENSMUSP00000109962 Ensembl peptide - ENSMUSP00000122266 NCBI entrez gene - 210973 See in Manteia. MGI - MGI:2384811 RefSeq - XM_006505848 RefSeq - NM_145958 RefSeq - XM_006505846 RefSeq - XM_006505847 RefSeq - XM_006505844 RefSeq - XM_006505845 RefSeq Peptide - NP_666070 swissprot - G3X9X1 Ensembl - ENSMUSG00000059486

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
kbtbd2	ENSDARG00000087226	Danio rerio
KBTBD2	ENSGALG00000038704	Gallus gallus
KBTBD2	ENSG00000170852	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Kbtbd8 / Q3UQV5 / Kelch repeat and BTB domain-containing protein 8 / Q8NFY9* / kelch repeat and BTB domain containing 8*	ENSMUSG00000030031	32
Kbtbd7 / Q86V97* / Q8WVZ9* / KBTBD6* / kelch repeat and BTB domain containing 6* / kelch repeat and BTB domain containing 7*	ENSMUSG00000043881	25
A2AUC9 / Klhl41 / Kelch-like protein 41 / O60662* / kelch like family member 41*	ENSMUSG00000075307	23
Klhl40 / kelch like family member 40 / Q2TBA0*	ENSMUSG00000074001	23
Klhl38 / Q8BSF5 / Kelch-like protein 38 / Q2WGJ6* / kelch like family member 38*	ENSMUSG00000022357	22
Klhl24 / Q8BRG6 / Kelch-like protein 24 / Q6TFL4* / kelch like family member 24*	ENSMUSG00000062901	22
Q9D618 / Kbtbd12 / Kelch repeat and BTB domain-containing protein 12 / Q3ZCT8* / kelch repeat and BTB domain containing 12*	ENSMUSG00000033182	22
Enc1 / O35709 / Ectoderm-neural cortex protein 1 / O14682* / ectodermal-neural cortex 1*	ENSMUSG00000041773	22
Klhl29 / Q80T74 / Kelch-like protein 29 / Q96CT2* / kelch like family member 29*	ENSMUSG00000020627	22
Kbtbd3 / Q8BHI4 / Kelch repeat and BTB domain-containing protein 3 / Q8NAB2* / kelch repeat and BTB domain containing 3*	ENSMUSG00000025893	21
Klhl30 / Q8C3F7 / Kelch-like protein 30 / Q0D2K2* / kelch like family member 30*	ENSMUSG00000026308	21
Klhl23 / Q6GQU2 / Kelch-like protein 23 / Q8NBE8* / kelch like family member 23*	ENSMUSG00000042155	21
Klhl6 / Q6V595 / Kelch-like protein 6 / Q8WZ60* / kelch like family member 6*	ENSMUSG00000043008	21
Klhl21 / Q3U410 / Kelch-like protein 21 / Q9UJP4* / kelch like family member 21*	ENSMUSG00000073700	21
Klhl35 / Q9CZ49 / Kelch-like protein 35 / Q6PF15* / kelch like family member 35*	ENSMUSG00000035298	20
Klhl25 / Q8R2P1 / Kelch-like protein 25 / Q9H0H3* / kelch like family member 25*	ENSMUSG00000055652	20
Kbtbd6 / uncharacterized protein LOC432879 / Q86V97* / Q8WVZ9* / KBTBD7* / kelch repeat and BTB domain containing 6* / kelch repeat and BTB domain containing 7*	ENSMUSG00000075502	18

Protein motifs (from Interpro)

Interpro ID	Name
IPR000210	BTB/POZ domain
IPR006652	Kelch repeat type 1
IPR011333	SKP1/BTB/POZ domain superfamily
IPR011705	BTB/Kelch-associated
IPR015915	Kelch-type beta propeller
IPR017096	BTB-kelch protein

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0016567	protein ubiquitination	IEA
cellular_component	GO:0031463	Cul3-RING ubiquitin ligase complex	IBA
molecular_function	GO:0004842	ubiquitin-protein transferase activity	IBA
molecular_function	GO:0005515	protein binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0000603	pale liver	"liver lacking normal coloration, often refers to bloodless condition" [J:18048]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Kbtbd2^em1Btlr/Kbtbd2^em1Btlr Genetic Background: Not Specified
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2 Allelic Composition: Kbtbd2^em1Btlr/Kbtbd2^em1Btlr Genetic Background: Not Specified Allelic Composition: Kbtbd2^m2Btlr/Kbtbd2^m2Btlr Genetic Background: C57BL/6J-Kbtbd2^m2Btlr
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0002079	increased circulating insulin level	"greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2 Allelic Composition: Kbtbd2^em1Btlr/Kbtbd2^em1Btlr Genetic Background: Not Specified
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Kbtbd2^em1Btlr/Kbtbd2^em1Btlr Genetic Background: Not Specified
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Kbtbd2^em1Btlr/Kbtbd2^em1Btlr,Pik3r1^em1Btlr/Pik3r1^em1Btlr Genetic Background: Not Specified
MP:0002941	increased circulating alanine transaminase level	"increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0003960	increased lean body mass	"more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0004893	decreased adiponectin level	"reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0005331	insulin resistance	"diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2 Allelic Composition: Kbtbd2^em1Btlr/Kbtbd2^em1Btlr Genetic Background: Not Specified
MP:0005343	increased circulating aspartate transaminase level	"greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kbtbd2^em1Btlr/Kbtbd2^em1Btlr,Pik3r1^em1Btlr/Pik3r1^em1Btlr Genetic Background: Not Specified
MP:0005668	decreased circulating leptin level	"less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0005670	abnormal white fat physiology	"functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0009289	decreased epididymal fat pad weight		Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0009293	decreased inguinal fat pad weight		Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0009355	increased liver triglyceride level	"higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2
MP:0013279	increased fasted circulating glucose level	"increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]	Show Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu},Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2 Allelic Composition: Kbtbd2^em1Btlr/Kbtbd2^em1Btlr Genetic Background: Not Specified
MP:0014142	increased body fat mass	"increased physical bulk or volume of fat in the whole body" [MGI:csmith]	Show Allelic Composition: Kbtbd2^em1Btlr/Kbtbd2^em1Btlr,Pik3r1^em1Btlr/Pik3r1^em1Btlr Genetic Background: Not Specified

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr