ENSMUSG00000073700


Mus musculus

Features
Gene ID: ENSMUSG00000073700
  
Biological name :Klhl21
  
Synonyms : Kelch-like protein 21 / Klhl21 / Q3U410
  
Possible biological names infered from orthology : kelch like family member 21 / Q9UJP4
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 152008803
Gene end: 152017680
  
Corresponding Affymetrix probe sets: 10510624 (MoGene1.0st)   1428081_at (Mouse Genome 430 2.0 Array)   1437897_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095380
NCBI entrez gene - 242785     See in Manteia.
MGI - MGI:1919288
RefSeq - NM_001033352
RefSeq Peptide - NP_001028524
swissprot - Q3U410
Ensembl - ENSMUSG00000073700
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klhl21ENSDARG00000039255Danio rerio
 KLHL21ENSGALG00000035211Gallus gallus
 KLHL21ENSG00000162413Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klhl30 / Q8C3F7 / Kelch-like protein 30 / Q0D2K2* / kelch like family member 30*ENSMUSG0000002630835
Klhl29 / Q80T74 / Kelch-like protein 29 / Q96CT2* / kelch like family member 29*ENSMUSG0000002062731
Klhl24 / Q8BRG6 / Kelch-like protein 24 / Q6TFL4* / kelch like family member 24*ENSMUSG0000006290129
Enc1 / O35709 / Ectoderm-neural cortex protein 1 / O14682* / ectodermal-neural cortex 1*ENSMUSG0000004177329
Klhl35 / Q9CZ49 / Kelch-like protein 35 / Q6PF15* / kelch like family member 35*ENSMUSG0000003529829
Klhl25 / Q8R2P1 / Kelch-like protein 25 / Q9H0H3* / kelch like family member 25*ENSMUSG0000005565229
Klhl38 / Q8BSF5 / Kelch-like protein 38 / Q2WGJ6* / kelch like family member 38*ENSMUSG0000002235728
Klhl23 / Q6GQU2 / Kelch-like protein 23 / Q8NBE8* / kelch like family member 23*ENSMUSG0000004215527
Klhl6 / Q6V595 / Kelch-like protein 6 / Q8WZ60* / kelch like family member 6*ENSMUSG0000004300827
Kbtbd7 / Q86V97* / Q8WVZ9* / KBTBD6* / kelch repeat and BTB domain containing 6* / kelch repeat and BTB domain containing 7*ENSMUSG0000004388125
Klhl40 / kelch like family member 40 / Q2TBA0*ENSMUSG0000007400123
Kbtbd2 / kelch repeat and BTB domain containing 2 / Q8IY47*ENSMUSG0000005948622
Q9D618 / Kbtbd12 / Kelch repeat and BTB domain-containing protein 12 / Q3ZCT8* / kelch repeat and BTB domain containing 12*ENSMUSG0000003318221
A2AUC9 / Klhl41 / Kelch-like protein 41 / O60662* / kelch like family member 41*ENSMUSG0000007530721
Kbtbd3 / Q8BHI4 / Kelch repeat and BTB domain-containing protein 3 / Q8NAB2* / kelch repeat and BTB domain containing 3*ENSMUSG0000002589321
Kbtbd6 / uncharacterized protein LOC432879 / Q86V97* / Q8WVZ9* / KBTBD7* / kelch repeat and BTB domain containing 6* / kelch repeat and BTB domain containing 7*ENSMUSG0000007550219
Kbtbd8 / Q3UQV5 / Kelch repeat and BTB domain-containing protein 8 / Q8NFY9* / kelch repeat and BTB domain containing 8*ENSMUSG0000003003119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR006652  Kelch repeat type 1
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated
 IPR015915  Kelch-type beta propeller
 IPR017096  BTB-kelch protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0035853 chromosome passenger complex localization to spindle midzone IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005827 polar microtubule IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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