ENSMUSG00000045193


Mus musculus

Features
Gene ID: ENSMUSG00000045193
  
Biological name :Cirbp
  
Synonyms : Cirbp / Cold-inducible RNA-binding protein / P60824
  
Possible biological names infered from orthology : Q14011
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 80165985
Gene end: 80172786
  
Corresponding Affymetrix probe sets: 10364712 (MoGene1.0st)   1416332_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121214
Ensembl peptide - ENSMUSP00000052642
Ensembl peptide - ENSMUSP00000101004
NCBI entrez gene - 12696     See in Manteia.
MGI - MGI:893588
RefSeq - XM_006513164
RefSeq - XM_006513165
RefSeq - NM_007705
RefSeq Peptide - NP_031731
swissprot - P60824
swissprot - K4DI65
swissprot - D3YU80
Ensembl - ENSMUSG00000045193
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cirbpaENSDARG00000103672Danio rerio
 cirbpbENSDARG00000013351Danio rerio
 CIRBPENSGALG00000030918Gallus gallus
 CIRBPENSG00000099622Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rbm3 / O89086 / RNA binding motif (RNP1, RRM) protein 3 / P98179* / RNA binding motif protein 3*ENSMUSG0000003116756
Rbmx / Q9WV02 / RNA binding motif protein, X chromosome / P38159* / RNA binding motif protein, X-linked*ENSMUSG0000003113455
Gm7324 / predicted gene 7324 / Q96E39* / RBMXL1* / RNA binding motif protein, X-linked like 1*ENSMUSG0000004923552
Q91VM5 / Rbmxl1 / RNA binding motif protein, X-linked-like-1 / Q96E39*ENSMUSG0000003707052
Rbmxl2 / Q8N7X1* / O75526* / RBMXL3* / RNA binding motif protein, X-linked like 2* / RNA binding motif protein, X-linked like 3*ENSMUSG0000007389451
Q60990 / Gm3376 / RNA-binding motif protein, Y chromosome, family 1 member B / Q15415* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / A6NDE4* / A6NEQ0* / P0C7P1* / P0DJD3* / RBMY1A1* ...ENSMUSG0000009652037
Gm10256 / P0C7P1* / P0DJD3* / Q15415* / A6NDE4* / A6NEQ0* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / RBMY1A1* / RNA binding motif protein, Y-linked, family 1, member B* / RNA bindi...ENSMUSG0000009585237
Gm10352 / P0C7P1* / P0DJD3* / Q15415* / A6NDE4* / A6NEQ0* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / RBMY1A1* / RNA binding motif protein, Y-linked, family 1, member B* / RNA bindi...ENSMUSG0000009198737
Gm4064 / P0C7P1* / P0DJD3* / Q15415* / A6NDE4* / A6NEQ0* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / RBMY1A1* / RNA binding motif protein, Y-linked, family 1, member B* / RNA bindin...ENSMUSG0000010205337
O35698 / Rbmy1a1 / RNA-binding motif protein, Y chromosome, family 1 member A1 / Q15415* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / A6NDE4* / A6NEQ0* / P0C7P1* / P0DJD3* / RNA bin...ENSMUSG0000009465836
O35698 / Gm21677 / predicted gene, 21677 / Q15415* / A6NDE4* / A6NEQ0* / P0C7P1* / P0DJD3* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / RBMY1A1* / RNA binding motif protein, Y-linked...ENSMUSG0000009391836
O35698 / Gm21704 / predicted gene, 21704 / Q15415* / A6NDE4* / A6NEQ0* / P0C7P1* / P0DJD3* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / RBMY1A1* / RNA binding motif protein, Y-linked...ENSMUSG0000009398736
O35698 / Gm21708 / predicted gene, 21708 / Q15415* / A6NDE4* / A6NEQ0* / P0C7P1* / P0DJD3* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / RBMY1A1* / RNA binding motif protein, Y-linked...ENSMUSG0000009594836
Gm21693 / P0C7P1* / P0DJD3* / Q15415* / A6NDE4* / A6NEQ0* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / RBMY1A1* / RNA binding motif protein, Y-linked, family 1, member B* / RNA bindi...ENSMUSG0000009451135
Tra2b / P62996 / Mus musculus transformer 2 beta (Tra2b), transcript variant 2, mRNA. / P62995* / transformer 2 beta homolog*ENSMUSG0000002285834
Tra2a / transformer 2 alpha / Q13595* / transformer 2 alpha homolog*ENSMUSG0000002981733
Gm29289 / P0C7P1* / P0DJD3* / Q15415* / A6NDE4* / A6NEQ0* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / RBMY1A1* / RNA binding motif protein, Y-linked, family 1, member B* / RNA bindi...ENSMUSG0000010166724


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR003954  RNA recognition motif domain, eukaryote
 IPR034278  RBM3/CIRBP, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0009411 response to UV ISO
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0034063 stress granule assembly IDA
 biological_processGO:0045727 positive regulation of translation ISO
 biological_processGO:0048255 mRNA stabilization ISO
 biological_processGO:0070417 cellular response to cold IDA
 biological_processGO:1902806 regulation of cell cycle G1/S phase transition IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0010494 cytoplasmic stress granule IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003730 mRNA 3"-UTR binding ISO
 molecular_functionGO:0008266 poly(U) RNA binding IDA
 molecular_functionGO:0030371 translation repressor activity IDA
 molecular_functionGO:0070181 small ribosomal subunit rRNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002685 abnormal proliferation of spermatogonia "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271]
Show

Allelic Composition: Fam20ctm1Lex/Fam20ctm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Fam20ctm1Lex/Fam20ctm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fam20ctm1Lex/Fam20ctm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Fam20ctm1Lex/Fam20ctm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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