ENSMUSG00000022858


Mus musculus

Features
Gene ID: ENSMUSG00000022858
  
Biological name :Tra2b
  
Synonyms : Mus musculus transformer 2 beta (Tra2b), transcript variant 2, mRNA. / P62996 / Tra2b
  
Possible biological names infered from orthology : P62995 / transformer 2 beta homolog
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B1
Gene start: 22244549
Gene end: 22266005
  
Corresponding Affymetrix probe sets: 10438621 (MoGene1.0st)   10498185 (MoGene1.0st)   1419543_a_at (Mouse Genome 430 2.0 Array)   1427432_a_at (Mouse Genome 430 2.0 Array)   1441466_at (Mouse Genome 430 2.0 Array)   1444509_at (Mouse Genome 430 2.0 Array)   1446496_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023564
Ensembl peptide - ENSMUSP00000123782
Ensembl peptide - ENSMUSP00000124846
NCBI entrez gene - 20462     See in Manteia.
MGI - MGI:106016
RefSeq - XM_017316896
RefSeq - NM_001330554
RefSeq - NM_009186
RefSeq - XM_006521877
RefSeq - XM_006521879
RefSeq Peptide - NP_001317484
RefSeq Peptide - NP_033212
RefSeq Peptide - NP_001317483
swissprot - F8WJG3
swissprot - P62996
swissprot - A0A0R4J1X8
Ensembl - ENSMUSG00000022858
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tra2bENSDARG00000002168Danio rerio
 TRA2BENSGALG00000006531Gallus gallus
 TRA2BENSG00000136527Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tra2a / transformer 2 alpha / Q13595* / transformer 2 alpha homolog*ENSMUSG0000002981769
Rbmx / Q9WV02 / RNA binding motif protein, X chromosome / P38159* / RNA binding motif protein, X-linked*ENSMUSG0000003113430
Q91VM5 / Rbmxl1 / RNA binding motif protein, X-linked-like-1 / Q96E39*ENSMUSG0000003707029
Rbmxl2 / Q8N7X1* / O75526* / RBMXL3* / RNA binding motif protein, X-linked like 2* / RNA binding motif protein, X-linked like 3*ENSMUSG0000007389429
Gm7324 / predicted gene 7324 / Q96E39* / RBMXL1* / RNA binding motif protein, X-linked like 1*ENSMUSG0000004923529
Gm21693 / P0C7P1* / P0DJD3* / Q15415* / A6NDE4* / A6NEQ0* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / RBMY1A1* / RNA binding motif protein, Y-linked, family 1, member B* / RNA bindi...ENSMUSG0000009451122
O35698 / Gm21704 / predicted gene, 21704 / Q15415* / A6NDE4* / A6NEQ0* / P0C7P1* / P0DJD3* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / RBMY1A1* / RNA binding motif protein, Y-linked...ENSMUSG0000009398721
Gm10352 / P0C7P1* / P0DJD3* / Q15415* / A6NDE4* / A6NEQ0* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / RBMY1A1* / RNA binding motif protein, Y-linked, family 1, member B* / RNA bindi...ENSMUSG0000009198721
O35698 / Rbmy1a1 / RNA-binding motif protein, Y chromosome, family 1 member A1 / Q15415* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / A6NDE4* / A6NEQ0* / P0C7P1* / P0DJD3* / RNA bin...ENSMUSG0000009465821
Gm4064 / P0C7P1* / P0DJD3* / Q15415* / A6NDE4* / A6NEQ0* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / RBMY1A1* / RNA binding motif protein, Y-linked, family 1, member B* / RNA bindin...ENSMUSG0000010205321
Q60990 / Gm3376 / RNA-binding motif protein, Y chromosome, family 1 member B / Q15415* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / A6NDE4* / A6NEQ0* / P0C7P1* / P0DJD3* / RBMY1A1* ...ENSMUSG0000009652021
O35698 / Gm21708 / predicted gene, 21708 / Q15415* / A6NDE4* / A6NEQ0* / P0C7P1* / P0DJD3* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / RBMY1A1* / RNA binding motif protein, Y-linked...ENSMUSG0000009594821
Gm10256 / P0C7P1* / P0DJD3* / Q15415* / A6NDE4* / A6NEQ0* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / RBMY1A1* / RNA binding motif protein, Y-linked, family 1, member B* / RNA bindi...ENSMUSG0000009585221
O35698 / Gm21677 / predicted gene, 21677 / Q15415* / A6NDE4* / A6NEQ0* / P0C7P1* / P0DJD3* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / RBMY1A1* / RNA binding motif protein, Y-linked...ENSMUSG0000009391821
Cirbp / P60824 / Cold-inducible RNA-binding protein / Q14011*ENSMUSG0000004519320
Rbm3 / O89086 / RNA binding motif (RNP1, RRM) protein 3 / P98179* / RNA binding motif protein 3*ENSMUSG0000003116719
Gm29289 / P0C7P1* / P0DJD3* / Q15415* / A6NDE4* / A6NEQ0* / RBMY1B* / RBMY1D* / RBMY1E* / RBMY1F* / RBMY1J* / RBMY1A1* / RNA binding motif protein, Y-linked, family 1, member B* / RNA bindi...ENSMUSG0000010166713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species IEA
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome IEA
 biological_processGO:0000398 mRNA splicing, via spliceosome IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0021796 cerebral cortex regionalization IMP
 biological_processGO:0043484 regulation of RNA splicing IEA
 biological_processGO:0048025 negative regulation of mRNA splicing, via spliceosome IDA
 biological_processGO:0048026 positive regulation of mRNA splicing, via spliceosome IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:1990403 embryonic brain development IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005637 nuclear inner membrane IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0036002 pre-mRNA binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0070717 poly-purine tract binding IDA


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Phox2btm4Jbr/Phox2b+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acacbtm1.2Lowl/Acacbtm1.2Lowl,Lepob/Lepob
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Acacbtm1.2Lowl/Acacbtm1.2Lowl,Lepob/Lepob
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Acacbtm1.2Lowl/Acacbtm1.2Lowl,Lepob/Lepob
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acacbtm1.2Lowl/Acacbtm1.2Lowl,Lepob/Lepob
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0003975 increased circulating VLDL triglyceride level "higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Phox2btm4Jbr/Phox2b+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Acacbtm1.2Lowl/Acacbtm1.2Lowl,Lepob/Lepob
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Phox2btm4Jbr/Phox2b+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Acacbtm1.2Lowl/Acacbtm1.2Lowl,Lepob/Lepob
Genetic Background: involves: 129S6/SvEvTac * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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