ENSMUSG00000053411


Mus musculus

Features
Gene ID: ENSMUSG00000053411
  
Biological name :Cbx7
  
Synonyms : Cbx7 / Chromobox protein homolog 7 / Q8VDS3
  
Possible biological names infered from orthology : chromobox 7 / O95931
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 79915807
Gene end: 79971119
  
Corresponding Affymetrix probe sets: 10430649 (MoGene1.0st)   1420039_s_at (Mouse Genome 430 2.0 Array)   1433557_at (Mouse Genome 430 2.0 Array)   1449713_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120748
Ensembl peptide - ENSMUSP00000118871
Ensembl peptide - ENSMUSP00000135246
Ensembl peptide - ENSMUSP00000086708
Ensembl peptide - ENSMUSP00000105244
Ensembl peptide - ENSMUSP00000105245
Ensembl peptide - ENSMUSP00000118813
NCBI entrez gene - 52609     See in Manteia.
MGI - MGI:1196439
RefSeq - XM_011245692
RefSeq - NM_144811
RefSeq - XM_006521144
RefSeq - XM_006521147
RefSeq - XM_006521148
RefSeq - XM_011245691
RefSeq Peptide - NP_659060
swissprot - Q8VDS3
swissprot - F6WJA6
swissprot - F8WHN2
swissprot - H3BK45
swissprot - D3YYK4
swissprot - D3YY71
Ensembl - ENSMUSG00000053411
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cbx7aENSDARG00000038025Danio rerio
 cbx7bENSDARG00000087181Danio rerio
 CBX7ENSGALG00000041236Gallus gallus
 CBX7ENSG00000100307Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cbx6 / Q9DBY5 / Chromobox protein homolog 6 / O95503* / chromobox 6*ENSMUSG0000008971546
Cbx8 / Q9QXV1 / Chromobox protein homolog 8 / Q9HC52* / chromobox 8*ENSMUSG0000002557844
Cbx4 / O55187 / E3 SUMO-protein ligase CBX4 / O00257* / chromobox 4*ENSMUSG0000003998944
Cbx2 / P30658 / Chromobox protein homolog 2 / Q14781* / chromobox 2*ENSMUSG0000002557742


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR016197  Chromo-like domain superfamily
 IPR017984  Chromo domain subgroup
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain
 IPR033773  CBX family C-terminal motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0003006 developmental process involved in reproduction IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0048733 sebaceous gland development IMP
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0031519 PcG protein complex ISS
 cellular_componentGO:0035102 PRC1 complex IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035064 methylated histone binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
Show

Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Cbx7tm1Afus/Cbx7+
Genetic Background: involves: C57BL/6J

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Cbx7tm1Afus/Cbx7+
Genetic Background: involves: C57BL/6J

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0012725 small sebaceous gland "decreased size of the sebum secreting glands of the hair shaft" [MGI:mnk]
Show

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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