Manteia

ENSMUSG00000089715

Mus musculus

Features

Gene ID:	ENSMUSG00000089715

Biological name :	Cbx6

Synonyms :	Cbx6 / Chromobox protein homolog 6 / Q9DBY5

Possible biological names infered from orthology :	chromobox 6 / O95503

Species:	Mus musculus

Chr. number:	15
Strand:	-1
Band:	E1
Gene start:	79823896
Gene end:	79834688

Corresponding Affymetrix probe sets:	1424407_s_at (Mouse Genome 430 2.0 Array) 1429290_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000105253 Ensembl peptide - ENSMUSP00000119037 Ensembl peptide - ENSMUSP00000105255 Ensembl peptide - ENSMUSP00000105252 NCBI entrez gene - 494448 See in Manteia. MGI - MGI:3512628 RefSeq - NM_028763 RefSeq Peptide - NP_083039 swissprot - D3Z329 swissprot - D3Z5F6 swissprot - Q3UK98 swissprot - Q9DBY5 Ensembl - ENSMUSG00000089715

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
cbx6a	ENSDARG00000071051	Danio rerio
cbx6b	ENSDARG00000097543	Danio rerio
CBX6	ENSGALG00000036867	Gallus gallus
CBX6	ENSG00000183741	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Cbx8 / Q9QXV1 / Chromobox protein homolog 8 / Q9HC52* / chromobox 8*	ENSMUSG00000025578	35
Cbx4 / O55187 / E3 SUMO-protein ligase CBX4 / O00257* / chromobox 4*	ENSMUSG00000039989	27
Cbx2 / P30658 / Chromobox protein homolog 2 / Q14781* / chromobox 2*	ENSMUSG00000025577	25
Cbx7 / Q8VDS3 / Chromobox protein homolog 7 / O95931* / chromobox 7*	ENSMUSG00000053411	18

Protein motifs (from Interpro)

Interpro ID	Name
IPR000953	Chromo/chromo shadow domain
IPR016197	Chromo-like domain superfamily
IPR017984	Chromo domain subgroup
IPR023779	Chromo domain, conserved site
IPR023780	Chromo domain
IPR033773	CBX family C-terminal motif

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0006325	chromatin organization	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
cellular_component	GO:0000792	heterochromatin	IDA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005694	chromosome	IEA
cellular_component	GO:0031519	PcG protein complex	IEA
molecular_function	GO:0003727	single-stranded RNA binding	IDA

Pathways (from Reactome)

Pathway description

Oxidative Stress Induced Senescence

RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Regulation of PTEN gene transcription

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000183	decreased circulating LDL cholesterol level	"less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000558	abnormal tibia morphology	"atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0001539	decreased number of caudal vertebrae	"reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002928	abnormal bile duct morphology	"malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0003019	increased circulating chloride level	"elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0003795	abnormal bone structure		Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0003826	abnormal Mullerian duct morphology	"malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0003960	increased lean body mass	"more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005553	increased circulating creatinine level	"greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005633	increased circulating sodium level	"greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0009820	abnormal liver vasculature morphology	"any structural anomaly of the blood vessel network of the bile-secreting exocrine gland" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010123	increased bone mineral content	"elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010418	perimembraneous ventricular septal defect	"abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013835	absent hypoglossal nerve	"absence of the motor nerve which innervates all the intrinsic and all but one of the extrinsic muscles of the tongue" [ISBN:0-683-40008-8]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013852	abnormal Mullerian duct topology	"aberrant position of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [ISBN:0-683-40008-8]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013967	abnormal infrahyoid muscle connection		Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013971	blood in lymph vessels		Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013986	abnormal vitelline vein topology	"abnormal position of the paired veins that carry blood from the yolk sac back to the embryo" [MGI:csmith]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0014001	abnormal vertebral artery topology	"abnormal position of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [MGI:csmith]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0014021	heterochrony		Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr