ENSMUSG00000039989


Mus musculus

Features
Gene ID: ENSMUSG00000039989
  
Biological name :Cbx4
  
Synonyms : Cbx4 / E3 SUMO-protein ligase CBX4 / O55187
  
Possible biological names infered from orthology : chromobox 4 / O00257
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 119077573
Gene end: 119086221
  
Corresponding Affymetrix probe sets: 10393620 (MoGene1.0st)   1419583_at (Mouse Genome 430 2.0 Array)   1440479_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026665
NCBI entrez gene - 12418     See in Manteia.
MGI - MGI:1195985
RefSeq - NM_007625
RefSeq Peptide - NP_031651
swissprot - O55187
Ensembl - ENSMUSG00000039989
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cbx4ENSDARG00000099441Danio rerio
 CBX4ENSGALG00000035911Gallus gallus
 CBX4ENSG00000141582Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cbx2 / P30658 / Chromobox protein homolog 2 / Q14781* / chromobox 2*ENSMUSG0000002557722
Cbx6 / Q9DBY5 / Chromobox protein homolog 6 / O95503* / chromobox 6*ENSMUSG0000008971520
Cbx8 / Q9QXV1 / Chromobox protein homolog 8 / Q9HC52* / chromobox 8*ENSMUSG0000002557819
Cbx7 / Q8VDS3 / Chromobox protein homolog 7 / O95931* / chromobox 7*ENSMUSG0000005341113


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR016197  Chromo-like domain superfamily
 IPR017984  Chromo domain subgroup
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain
 IPR033773  CBX family C-terminal motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016925 protein sumoylation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031519 PcG protein complex IEA
 cellular_componentGO:0035102 PRC1 complex IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003727 single-stranded RNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity ISO
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0032183 SUMO binding IEA
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0051219 phosphoprotein binding IPI


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000704 abnormal thymus development "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Cbx4tm1.1Gxu/Cbx4tm1.2Gxu,Tg(Foxn1-cre)1Tbo/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Cbx4tm1.1Gxu/Cbx4tm1.2Gxu,Tg(Foxn1-cre)1Tbo/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbx4tm1.1Gxu/Cbx4tm1.2Gxu,Tg(Foxn1-cre)1Tbo/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003763 abnormal thymus physiology "anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Cbx4tm1.1Gxu/Cbx4tm1.2Gxu,Tg(Foxn1-cre)1Tbo/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cbx4tm1.1Gxu/Cbx4tm1.2Gxu,Tg(Foxn1-cre)1Tbo/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cbx4tm1.1Gxu/Cbx4tm1.2Gxu,Tg(Foxn1-cre)1Tbo/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex






 

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