ENSG00000141582


Homo sapiens

Features
Gene ID: ENSG00000141582
  
Biological name :CBX4
  
Synonyms : CBX4 / chromobox 4 / O00257
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.3
Gene start: 79833156
Gene end: 79839429
  
Corresponding Affymetrix probe sets: 206724_at (Human Genome U133 Plus 2.0 Array)   227558_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000415348
Ensembl peptide - ENSP00000461198
Ensembl peptide - ENSP00000269397
NCBI entrez gene - 8535     See in Manteia.
OMIM - 603079
RefSeq - NM_003655
RefSeq Peptide - NP_003646
swissprot - A0A0S2Z5B2
swissprot - F8WCW6
swissprot - I3L4F1
swissprot - O00257
Ensembl - ENSG00000141582
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cbx4ENSDARG00000099441Danio rerio
 CBX4ENSGALG00000035911Gallus gallus
 Cbx4ENSMUSG00000039989Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CBX2 / Q14781 / chromobox 2ENSG0000017389422
CBX6 / O95503 / chromobox 6ENSG0000018374120
CBX8 / Q9HC52 / chromobox 8ENSG0000014157018
CBX7 / O95931 / chromobox 7ENSG0000010030717


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR016197  Chromo-like domain superfamily
 IPR017984  Chromo domain subgroup
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain
 IPR033773  CBX family C-terminal motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016925 protein sumoylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031519 PcG protein complex IDA
 cellular_componentGO:0035102 PRC1 complex IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity EXP
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0032183 SUMO binding IDA
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex






 

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