ENSG00000141570


Homo sapiens

Features
Gene ID: ENSG00000141570
  
Biological name :CBX8
  
Synonyms : CBX8 / chromobox 8 / Q9HC52
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.3
Gene start: 79792132
Gene end: 79801683
  
Corresponding Affymetrix probe sets: 219755_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000269385
Ensembl peptide - ENSP00000408753
Ensembl peptide - ENSP00000405058
NCBI entrez gene - 57332     See in Manteia.
OMIM - 617354
RefSeq - NM_020649
RefSeq Peptide - NP_065700
swissprot - C9JM54
swissprot - C9J6K3
swissprot - Q9HC52
Ensembl - ENSG00000141570
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cbx8aENSDARG00000087327Danio rerio
 cbx8bENSDARG00000098771Danio rerio
 CBX8ENSGALG00000026548Gallus gallus
 Cbx8ENSMUSG00000025578Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CBX6 / O95503 / chromobox 6ENSG0000018374138
CBX2 / Q14781 / chromobox 2ENSG0000017389428
CBX4 / O00257 / chromobox 4ENSG0000014158226
CBX7 / O95931 / chromobox 7ENSG0000010030724


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR016197  Chromo-like domain superfamily
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain
 IPR033773  CBX family C-terminal motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0016574 histone ubiquitination IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0045739 positive regulation of DNA repair IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0000792 heterochromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0031519 PcG protein complex IEA
 cellular_componentGO:0035102 PRC1 complex IDA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0097027 ubiquitin-protein transferase activator activity IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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