ENSMUSG00000025578


Mus musculus

Features
Gene ID: ENSMUSG00000025578
  
Biological name :Cbx8
  
Synonyms : Cbx8 / Chromobox protein homolog 8 / Q9QXV1
  
Possible biological names infered from orthology : chromobox 8 / Q9HC52
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 119036305
Gene end: 119040969
  
Corresponding Affymetrix probe sets: 10393614 (MoGene1.0st)   1419198_at (Mouse Genome 430 2.0 Array)   1419199_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026663
NCBI entrez gene - 30951     See in Manteia.
MGI - MGI:1353589
RefSeq - NM_013926
RefSeq - XM_017314589
RefSeq Peptide - NP_038954
swissprot - Q9QXV1
Ensembl - ENSMUSG00000025578
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cbx8aENSDARG00000087327Danio rerio
 cbx8bENSDARG00000098771Danio rerio
 CBX8ENSGALG00000026548Gallus gallus
 CBX8ENSG00000141570Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cbx6 / Q9DBY5 / Chromobox protein homolog 6 / O95503* / chromobox 6*ENSMUSG0000008971540
Cbx2 / P30658 / Chromobox protein homolog 2 / Q14781* / chromobox 2*ENSMUSG0000002557729
Cbx4 / O55187 / E3 SUMO-protein ligase CBX4 / O00257* / chromobox 4*ENSMUSG0000003998929
Cbx7 / Q8VDS3 / Chromobox protein homolog 7 / O95931* / chromobox 7*ENSMUSG0000005341119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR016197  Chromo-like domain superfamily
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain
 IPR033773  CBX family C-terminal motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006342 chromatin silencing ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0016574 histone ubiquitination IDA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0045739 positive regulation of DNA repair IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0031519 PcG protein complex IEA
 cellular_componentGO:0035102 PRC1 complex IEA
 molecular_functionGO:0003727 single-stranded RNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0097027 ubiquitin-protein transferase activator activity IDA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Cbx8tm1.1Hko/Cbx8tm1.1Hko
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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