ENSMUSG00000025577


Mus musculus

Features
Gene ID: ENSMUSG00000025577
  
Biological name :Cbx2
  
Synonyms : Cbx2 / Chromobox protein homolog 2 / P30658
  
Possible biological names infered from orthology : chromobox 2 / Q14781
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 119022962
Gene end: 119031270
  
Corresponding Affymetrix probe sets: 10383055 (MoGene1.0st)   1422059_at (Mouse Genome 430 2.0 Array)   1434116_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026662
NCBI entrez gene - 12416     See in Manteia.
MGI - MGI:88289
RefSeq - NM_007623
RefSeq - XM_006532104
RefSeq Peptide - NP_031649
swissprot - P30658
Ensembl - ENSMUSG00000025577
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cbx2ENSDARG00000044938Danio rerio
 CBX2ENSGALG00000023338Gallus gallus
 CBX2ENSG00000173894Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cbx4 / O55187 / E3 SUMO-protein ligase CBX4 / O00257* / chromobox 4*ENSMUSG0000003998923
Cbx8 / Q9QXV1 / Chromobox protein homolog 8 / Q9HC52* / chromobox 8*ENSMUSG0000002557820
Cbx6 / Q9DBY5 / Chromobox protein homolog 6 / O95503* / chromobox 6*ENSMUSG0000008971520
Cbx7 / Q8VDS3 / Chromobox protein homolog 7 / O95931* / chromobox 7*ENSMUSG0000005341113


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR016197  Chromo-like domain superfamily
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain
 IPR033773  CBX family C-terminal motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045137 development of primary sexual characteristics IEA
 cellular_componentGO:0000791 euchromatin IDA
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031519 PcG protein complex IEA
 cellular_componentGO:0035102 PRC1 complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035064 methylated histone binding IDA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
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Allelic Composition: Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
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Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Cacna1btm1b(KOMP)Wtsi/Cacna1btm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cacna1btm1b(KOMP)Wtsi/H

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001939 secondary sex reversal "secondary sexual phenotype is not consistent with the chromosomal sex, i.e., internal and/or external genitalia are inconsistent with chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0002211 abnormal primary sex determination "aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0002212 abnormal secondary sex determination "gonadal development may or may not be normal, and the phenotype of the animal outside the gonad does not match chromosomal sex or is ambiguous" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0002213 true hermaphroditism "having both ovarian and testicular tissue present" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

Allelic Composition: Cbx2tm1Ykf/Cbx2+
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0004607 abnormal cervical atlas morphology "any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005644 agonadal "denoting the absence of gonads" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0010728 fusion of atlas and occipital bones "union of elements of the atlas and the bone at the lower, posterior part of the skull into one structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0012283 decreased sternebra number "reduced average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:anna]
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Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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