ENSMUSG00000061527


Mus musculus

Features
Gene ID: ENSMUSG00000061527
  
Biological name :Krt5
  
Synonyms : keratin 5 / Krt5 / Q922U2
  
Possible biological names infered from orthology : P13647
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F2
Gene start: 101707070
Gene end: 101712898
  
Corresponding Affymetrix probe sets: 10432785 (MoGene1.0st)   1424096_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023709
NCBI entrez gene - 110308     See in Manteia.
MGI - MGI:96702
RefSeq - NM_027011
RefSeq Peptide - NP_081287
swissprot - Q32P04
swissprot - Q922U2
Ensembl - ENSMUSG00000061527
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 krt4ENSDARG00000017624Danio rerio
 krt5ENSDARG00000058371Danio rerio
 krt8ENSDARG00000058358Danio rerio
 zgc:158846ENSDARG00000058462Danio rerio
 KRT5ENSG00000186081Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Krt75 / Q8BGZ7 / Keratin, type II cytoskeletal 75 / O95678* / keratin 75*ENSMUSG0000002298672
Krt6a / P50446 / Keratin, type II cytoskeletal 6A / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000005835471
Krt6b / keratin 6B / KRT6A* / KRT6C* / P02538* / P04259* / P48668* / keratin 6A* / keratin 6C*ENSMUSG0000002304170
Krt90ENSMUSG0000004869963
Gm5478 / KRT6A* / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000009524159
Gm5414 / KRT6A* / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000006423259
Krt76 / Q3UV17 / Keratin, type II cytoskeletal 2 oral / Q01546* / keratin 76*ENSMUSG0000007540258
Krt79 / Q8VED5 / Keratin, type II cytoskeletal 79 / Q5XKE5* / keratin 79*ENSMUSG0000006139757
Krt4 / P07744 / Keratin, type II cytoskeletal 4 / P19013* / keratin 4*ENSMUSG0000005966857
Krt8 / P11679 / Keratin, type II cytoskeletal 8 / P05787* / keratin 8*ENSMUSG0000004938251
Krt7 / Q9DCV7 / Keratin, type II cytoskeletal 7 / P08729* / keratin 7*ENSMUSG0000002303950


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR003054  Keratin, type II
 IPR018039  Intermediate filament protein, conserved site
 IPR032444  Keratin type II head


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005882 intermediate filament ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0045095 keratin filament ISO
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000468 abnormal esophageal epithelium morphology "malformation of the epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Fntbtm1Bbd/Fntbtm1.1Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fntbtm1Bbd/Fntbtm1.1Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fntbtm1Bbd/Fntbtm1.1Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Fntbtm1Bbd/Fntbtm1.1Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fntbtm1Bbd/Fntbtm1.1Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fntbtm1Bbd/Fntbtm1.1Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Fntbtm1Bbd/Fntbtm1.1Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fntbtm1Bbd/Fntbtm1.1Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Fntbtm1Bbd/Fntbtm1.1Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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