ENSMUSG00000058354


Mus musculus

Features
Gene ID: ENSMUSG00000058354
  
Biological name :Krt6a
  
Synonyms : Keratin, type II cytoskeletal 6A / Krt6a / P50446
  
Possible biological names infered from orthology : keratin 6A / keratin 6B / keratin 6C / KRT6B / KRT6C / P02538 / P04259 / P48668
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F2
Gene start: 101689910
Gene end: 101694307
  
Corresponding Affymetrix probe sets: 10432780 (MoGene1.0st)   1422783_a_at (Mouse Genome 430 2.0 Array)   1422784_at (Mouse Genome 430 2.0 Array)   1427700_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023788
NCBI entrez gene - 16687     See in Manteia.
MGI - MGI:1100845
RefSeq - NM_008476
RefSeq Peptide - NP_032502
swissprot - P50446
Ensembl - ENSMUSG00000058354
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 krt4ENSDARG00000017624Danio rerio
 krt5ENSDARG00000058371Danio rerio
 krt8ENSDARG00000058358Danio rerio
 zgc:158846ENSDARG00000058462Danio rerio
 KRT6AENSG00000205420Homo sapiens
 KRT6BENSG00000185479Homo sapiens
 KRT6CENSG00000170465Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Krt6b / keratin 6B / KRT6A* / KRT6C* / P02538* / P04259* / P48668* / keratin 6A* / keratin 6C*ENSMUSG0000002304197
Krt5 / Q922U2 / keratin 5 / P13647*ENSMUSG0000006152774
Gm5414 / KRT6A* / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000006423272
Gm5478 / KRT6A* / KRT6B* / KRT6C* / P04259* / P48668* / P02538* / keratin 6A* / keratin 6B* / keratin 6C*ENSMUSG0000009524172
Krt75 / Q8BGZ7 / Keratin, type II cytoskeletal 75 / O95678* / keratin 75*ENSMUSG0000002298672
Krt90ENSMUSG0000004869964
Krt76 / Q3UV17 / Keratin, type II cytoskeletal 2 oral / Q01546* / keratin 76*ENSMUSG0000007540260
Krt79 / Q8VED5 / Keratin, type II cytoskeletal 79 / Q5XKE5* / keratin 79*ENSMUSG0000006139758
Krt4 / P07744 / Keratin, type II cytoskeletal 4 / P19013* / keratin 4*ENSMUSG0000005966858
Krt7 / Q9DCV7 / Keratin, type II cytoskeletal 7 / P08729* / keratin 7*ENSMUSG0000002303953
Krt8 / P11679 / Keratin, type II cytoskeletal 8 / P05787* / keratin 8*ENSMUSG0000004938252


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR003054  Keratin, type II
 IPR018039  Intermediate filament protein, conserved site
 IPR032444  Keratin type II head


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002009 morphogenesis of an epithelium IMP
 biological_processGO:0016055 Wnt signaling pathway IDA
 biological_processGO:0031424 keratinization IGI
 biological_processGO:0042060 wound healing IMP
 biological_processGO:0044140 negative regulation of growth of symbiont on or near host surface IMP
 biological_processGO:0045109 intermediate filament organization IGI
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IMP
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0045095 keratin filament IEA
 molecular_functionGO:0005198 structural molecule activity IEA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krt6a/Krt6btm1Der/Krt6b+,Krt75tm1Der/Krt75+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0000467 abnormal esophagus morphology "malformation of the part of the digestive canal through which food passes from the pharynx to the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npc1l1tm1Yaio/Npc1l1tm1Yaio
Genetic Background: C57BL/6-Npc1l1tm1Yaio

Allelic Composition: Krt6a/Krt6btm1Der/Krt6a+,Krt75tm1Der/Krt75+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0000763 abnormal filiform papillae "malformed keratinized projections on the dorsal surface of the tongue" [J:45400]
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Npc1l1tm1Yaio/Npc1l1tm1Yaio
Genetic Background: C57BL/6-Npc1l1tm1Yaio

Allelic Composition: Krt6a/Krt6btm1Cou/Krt6a/Krt6btm1Cou
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krt6a/Krt6btm1Cou/Krt6a/Krt6btm1Cou
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Foxa2tm1Jrt/Foxa2tm1Khk,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Npc1l1tm1Yaio/Npc1l1tm1Yaio
Genetic Background: C57BL/6-Npc1l1tm1Yaio

 MP:0003756 abnormal hard palate "abnormality in the anterior part of the palate that is supported by and includes the palatal extensions of the maxillary and palatine bones " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Krt6a/Krt6btm1Cou/Krt6a/Krt6btm1Cou
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Npc1l1tm1Yaio/Npc1l1tm1Yaio
Genetic Background: C57BL/6-Npc1l1tm1Yaio

Allelic Composition: Krt6a/Krt6btm1Cou/Krt6a/Krt6btm1Cou
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Krt6a/Krt6btm1Cou/Krt6a/Krt6btm1Cou
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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