ENSMUSG00000061887


Mus musculus

Features
Gene ID: ENSMUSG00000061887
  
Biological name :Ssbp3
  
Synonyms : Q9D032 / Single-stranded DNA-binding protein 3 / Ssbp3
  
Possible biological names infered from orthology : Q9BWW4
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C7
Gene start: 106910701
Gene end: 107049694
  
Corresponding Affymetrix probe sets: 10506603 (MoGene1.0st)   1425940_a_at (Mouse Genome 430 2.0 Array)   1427917_s_at (Mouse Genome 430 2.0 Array)   1443554_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120323
Ensembl peptide - ENSMUSP00000072536
Ensembl peptide - ENSMUSP00000095547
Ensembl peptide - ENSMUSP00000116248
Ensembl peptide - ENSMUSP00000030367
NCBI entrez gene - 72475     See in Manteia.
MGI - MGI:1919725
RefSeq - XM_006503420
RefSeq - XM_006503413
RefSeq - XM_006503414
RefSeq - XM_006503415
RefSeq - XM_006503416
RefSeq - XM_006503417
RefSeq - XM_006503419
RefSeq - NM_023672
RefSeq - NM_198438
RefSeq - XM_006503411
RefSeq - XM_006503412
RefSeq Peptide - NP_076161
RefSeq Peptide - NP_940840
swissprot - B1AS37
swissprot - B1AS34
swissprot - Q9D032
swissprot - B1AS33
Ensembl - ENSMUSG00000061887
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ssbp3aENSDARG00000058237Danio rerio
 ssbp3bENSDARG00000030155Danio rerio
 SSBP3ENSGALG00000010774Gallus gallus
 SSBP3ENSG00000157216Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ssbp2 / Q9CYZ8 / Single-stranded DNA-binding protein 2 / P81877*ENSMUSG0000000399276
Ssbp4 / single stranded DNA binding protein 4 / Q9BWG4*ENSMUSG0000007000365


Protein motifs (from Interpro)
Interpro ID Name
 IPR006594  LIS1 homology motif
 IPR008116  Sequence-specific single-strand DNA-binding protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0021501 prechordal plate formation IMP
 biological_processGO:0021547 midbrain-hindbrain boundary initiation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0060322 head development IGI
 biological_processGO:0060323 head morphogenesis IMP
 biological_processGO:0065003 protein-containing complex assembly IMP
 biological_processGO:2000744 positive regulation of anterior head development IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000141 abnormal vertebral body morphology "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Lhx1tm1Bhr/Lhx1+,Ssbp3Tg(SOD1)1Hssk/Ssbp3+
Genetic Background: involves: 129S7/SvEvBrd * C3H/He * C57BL/6 * ICR

Allelic Composition: Ldb1tm1Lmgd/Ldb1+,Ssbp3Tg(SOD1)1Hssk/Ssbp3+
Genetic Background: involves: C3H/He * C57BL/6

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Ssbp3Gt(XB276)Byg/Ssbp3Gt(XB276)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Ssbp3Gt(XB276)Byg/Ssbp3Gt(XB276)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ssbp3Tg(SOD1)1Hssk/Ssbp3+
Genetic Background: involves: C3H/He * C57BL/6

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ssbp3Gt(XB276)Byg/Ssbp3Gt(XB276)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx1tm1Bhr/Lhx1+,Ssbp3Tg(SOD1)1Hssk/Ssbp3+
Genetic Background: involves: 129S7/SvEvBrd * C3H/He * C57BL/6 * ICR

Allelic Composition: Ssbp3Tg(SOD1)1Hssk/Ssbp3+
Genetic Background: involves: C3H/He * C57BL/6

Allelic Composition: Ssbp3Gt(RRB078)Byg/Ssbp3Gt(RRB078)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx1tm1Bhr/Lhx1+,Ssbp3Tg(SOD1)1Hssk/Ssbp3+
Genetic Background: involves: 129S7/SvEvBrd * C3H/He * C57BL/6 * ICR

Allelic Composition: Ldb1tm1Lmgd/Ldb1+,Ssbp3Tg(SOD1)1Hssk/Ssbp3+
Genetic Background: involves: C3H/He * C57BL/6

 MP:0004096 abnormal midbrain-hindbrain boundary development "anomaly in the formation of the midbrain-hindbrain domain, comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; an organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx1tm1Bhr/Lhx1+,Ssbp3Tg(SOD1)1Hssk/Ssbp3+
Genetic Background: involves: 129S7/SvEvBrd * C3H/He * C57BL/6 * ICR

 MP:0004388 absent prechordal plate "absence of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann s organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ssbp3Gt(XB276)Byg/Ssbp3Gt(XB276)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ssbp3Gt(XB276)Byg/Ssbp3Gt(XB276)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0011259 abnormal cephalic neural fold morphology "any structural anomaly of the elevated margins of the neural groove that are located in the future cephalic region of the embryo" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0012087 absent midbrain "absence of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna]
Show

Allelic Composition: Ssbp3Gt(XB276)Byg/Ssbp3Gt(XB276)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0012089 decreased midbrain size "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
Show

Allelic Composition: Ssbp3Gt(XB276)Byg/Ssbp3Gt(XB276)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0012136 absent forebrain "absence of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Ssbp3Gt(XB276)Byg/Ssbp3Gt(XB276)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0012176 abnormal head development "anomaly in the process in which the anatomical structures of the head are generated and organized" [GO:0060323]
Show

Allelic Composition: Ssbp3Gt(XB276)Byg/Ssbp3Gt(XB276)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0012283 decreased sternebra number "reduced average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:anna]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0012517 absent diencephalon "absence or loss of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MGI:anna]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0030324 abnormal anterior head development "any anomaly in the process in which the anatomical structures of the anterior part of the head are generated and organized" [GO:0097065, MGI:anna]
Show

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr