ENSMUSG00000063229


Mus musculus

Features
Gene ID: ENSMUSG00000063229
  
Biological name :Ldha
  
Synonyms : Ldha / L-lactate dehydrogenase A chain / P06151
  
Possible biological names infered from orthology : lactate dehydrogenase A / P00338
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 46841475
Gene end: 46855627
  
Corresponding Affymetrix probe sets: 10553301 (MoGene1.0st)   1419737_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103267
Ensembl peptide - ENSMUSP00000148190
Ensembl peptide - ENSMUSP00000148107
Ensembl peptide - ENSMUSP00000148046
Ensembl peptide - ENSMUSP00000147988
Ensembl peptide - ENSMUSP00000147825
Ensembl peptide - ENSMUSP00000147697
Ensembl peptide - ENSMUSP00000147640
Ensembl peptide - ENSMUSP00000147460
Ensembl peptide - ENSMUSP00000147293
Ensembl peptide - ENSMUSP00000123356
Ensembl peptide - ENSMUSP00000036386
Ensembl peptide - ENSMUSP00000097661
NCBI entrez gene - 16828     See in Manteia.
MGI - MGI:96759
RefSeq - NM_010699
RefSeq - NM_001136069
RefSeq Peptide - NP_001129541
RefSeq Peptide - NP_034829
swissprot - A0A1B0GS79
swissprot - A0A1B0GRW9
swissprot - A0A1B0GRS2
swissprot - A0A1B0GRC1
swissprot - A0A1B0GQX5
swissprot - P06151
swissprot - D3YZQ9
swissprot - Q564E2
swissprot - A0A1B0GT41
swissprot - A0A1B0GSX0
swissprot - A0A1B0GSR9
swissprot - A0A1B0GSL7
Ensembl - ENSMUSG00000063229
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ldhaENSDARG00000101251Danio rerio
 LDHAENSGALG00000006300Gallus gallus
 LDHAENSG00000134333Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ldhb / P16125 / L-lactate dehydrogenase B chain / P07195* / lactate dehydrogenase B*ENSMUSG0000003024670
Ldhc / P00342 / lactate dehydrogenase C / P07864*ENSMUSG0000003085166
Ldhal6b / lactate dehydrogenase A like 6B / Q9BYZ2*ENSMUSG0000010195962
Uevld / Q3U1V6 / UEV and lactate/malate dehyrogenase domains / Q8IX04*ENSMUSG0000004326237


Protein motifs (from Interpro)
Interpro ID Name
 IPR001236  Lactate/malate dehydrogenase, N-terminal
 IPR001557  L-lactate/malate dehydrogenase
 IPR011304  L-lactate dehydrogenase
 IPR015955  Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
 IPR018177  L-lactate dehydrogenase, active site
 IPR022383  Lactate/malate dehydrogenase, C-terminal
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006089 lactate metabolic process IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019244 lactate biosynthetic process from pyruvate IC
 biological_processGO:0019661 glucose catabolic process to lactate via pyruvate IMP
 biological_processGO:0019674 NAD metabolic process IEA
 biological_processGO:0019752 carboxylic acid metabolic process IEA
 biological_processGO:0031668 cellular response to extracellular stimulus IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0048569 post-embryonic animal organ development IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0035686 sperm fibrous sheath IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004457 lactate dehydrogenase activity IEA
 molecular_functionGO:0004459 L-lactate dehydrogenase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ldhaa-m6Neu/Ldhaa-m6Neu
Genetic Background: C3.Cg-Ldhaa-m6Neu

Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: involves: 101/El * C3H/El

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: involves: 101/El * C3H/El

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: involves: 101/El * C3H/El

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ldhaa-m12Neu/Ldhaa-m12Neu
Genetic Background: C3H/El-Ldhaa-m12Neu

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ldhaa-m6Neu/Ldhaa-m6Neu
Genetic Background: C3.Cg-Ldhaa-m6Neu

Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: involves: 101/El * C3H/El

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ldhaa-m4Neu/Ldhaa-m4Neu
Genetic Background: C3.Cg-Ldhaa-m4Neu

Allelic Composition: Ldhaa-m6Neu/Ldhaa-m6Neu
Genetic Background: C3.Cg-Ldhaa-m6Neu

Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: involves: 101/El * C3H/El

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: involves: 101/El * C3H/El

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ldhaa-m6Neu/Ldhaa-m6Neu
Genetic Background: C3.Cg-Ldhaa-m6Neu

Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: involves: 101/El * C3H/El

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ldhaa-m6Neu/Ldhaa-m6Neu
Genetic Background: C3.Cg-Ldhaa-m6Neu

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ldhaa-m12Neu/Ldhaa-m12Neu
Genetic Background: C3H/El-Ldhaa-m12Neu

Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: C3.Cg-Ldhaa-m1Neu

Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: involves: 101/El * C3H/El

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: C3.Cg-Ldhaa-m1Neu

Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: involves: 101/El * C3H/El

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: C3.Cg-Ldhaa-m1Neu

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lama1tm1.1Arhi/Lama1tm1.2Arhi,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: involves: 101/El * C3H/El

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Ldhaa-m6Neu/Ldhaa-m6Neu
Genetic Background: C3.Cg-Ldhaa-m6Neu

 MP:0005571 decreased lactate dehydrogenase level "less than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm4(EEF1A1-EGFP)Npa/Gt(ROSA)26Sor+
Genetic Background: BALB/c-Gt(ROSA)26Sortm4(EEF1A1-EGFP)Npa

Allelic Composition: Ldhaa-m7Neu/Ldhaa-m7Neu
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: Ldhaa-m9Neu/Ldha+
Genetic Background: involves: 102/El * C3H/El

Allelic Composition: Ldhaa-m7Neu/Ldha+
Genetic Background: involves: 102/El * C3H/El

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: C3.Cg-Ldhaa-m1Neu

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: involves: 101/El * C3H/El

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: involves: 101/El * C3H/El

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Agtpbp1pcd-8J/Agtpbp1pcd-8J
Genetic Background: BALB/cJ-Agtpbp1pcd-8J/GrsrJ

Allelic Composition: Ldhaa-m12Neu/Ldhaa-m12Neu
Genetic Background: C3H/El-Ldhaa-m12Neu

Allelic Composition: Ldhaa-m3Neu/Ldhaa-m3Neu
Genetic Background: C3.Cg-Ldhaa-m3Neu

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Agtpbp1pcd-8J/Agtpbp1pcd-8J
Genetic Background: BALB/cJ-Agtpbp1pcd-8J/GrsrJ

Allelic Composition: Ldhaa-m4Neu/Ldhaa-m4Neu
Genetic Background: C3.Cg-Ldhaa-m4Neu

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: F8tm2Kaz/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ldhaa-m3Neu/Ldhaa-m3Neu
Genetic Background: C3.Cg-Ldhaa-m3Neu

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ldhaa-m7Neu/Ldhaa-m7Neu
Genetic Background: involves: 102/El * C3H/El

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000063229 Ldha / P06151 / L-lactate dehydrogenase A chain / P00338* / lactate dehydrogenase A*  / complex
 ENSMUSG00000030246 Ldhb / P16125 / L-lactate dehydrogenase B chain / P07195* / lactate dehydrogenase B*  / complex






 

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