ENSMUSG00000030246


Mus musculus

Features
Gene ID: ENSMUSG00000030246
  
Biological name :Ldhb
  
Synonyms : Ldhb / L-lactate dehydrogenase B chain / P16125
  
Possible biological names infered from orthology : lactate dehydrogenase B / P07195
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: G2
Gene start: 142490249
Gene end: 142507957
  
Corresponding Affymetrix probe sets: 10462035 (MoGene1.0st)   10549097 (MoGene1.0st)   1416183_a_at (Mouse Genome 430 2.0 Array)   1434499_a_at (Mouse Genome 430 2.0 Array)   1448237_x_at (Mouse Genome 430 2.0 Array)   1455235_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116014
Ensembl peptide - ENSMUSP00000145467
Ensembl peptide - ENSMUSP00000145261
Ensembl peptide - ENSMUSP00000032373
NCBI entrez gene - 16832     See in Manteia.
MGI - MGI:96763
RefSeq - NM_001302765
RefSeq - NM_001316322
RefSeq - NM_008492
RefSeq Peptide - NP_001289694
RefSeq Peptide - NP_001303251
RefSeq Peptide - NP_032518
swissprot - P16125
swissprot - A0A0N4SWC9
swissprot - A0A0N4SVV8
swissprot - D3Z7F0
Ensembl - ENSMUSG00000030246
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ldhbaENSDARG00000019644Danio rerio
 ldhbbENSDARG00000071076Danio rerio
 LDHBENSGALG00000035836Gallus gallus
 LDHBENSG00000111716Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ldha / P06151 / L-lactate dehydrogenase A chain / P00338* / lactate dehydrogenase A*ENSMUSG0000006322975
Ldhc / P00342 / lactate dehydrogenase C / P07864*ENSMUSG0000003085164
Ldhal6b / lactate dehydrogenase A like 6B / Q9BYZ2*ENSMUSG0000010195962
Uevld / Q3U1V6 / UEV and lactate/malate dehyrogenase domains / Q8IX04*ENSMUSG0000004326238


Protein motifs (from Interpro)
Interpro ID Name
 IPR001236  Lactate/malate dehydrogenase, N-terminal
 IPR001557  L-lactate/malate dehydrogenase
 IPR011304  L-lactate dehydrogenase
 IPR015955  Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
 IPR018177  L-lactate dehydrogenase, active site
 IPR022383  Lactate/malate dehydrogenase, C-terminal
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006089 lactate metabolic process IEA
 biological_processGO:0019244 lactate biosynthetic process from pyruvate IC
 biological_processGO:0019674 NAD metabolic process IEA
 biological_processGO:0019752 carboxylic acid metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004457 lactate dehydrogenase activity IEA
 molecular_functionGO:0004459 L-lactate dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000063229 Ldha / P06151 / L-lactate dehydrogenase A chain / P00338* / lactate dehydrogenase A*  / complex
 ENSMUSG00000030246 Ldhb / P16125 / L-lactate dehydrogenase B chain / P07195* / lactate dehydrogenase B*  / complex






 

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