ENSMUSG00000030851


Mus musculus

Features
Gene ID: ENSMUSG00000030851
  
Biological name :Ldhc
  
Synonyms : lactate dehydrogenase C / Ldhc / P00342
  
Possible biological names infered from orthology : P07864
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 46861203
Gene end: 46878142
  
Corresponding Affymetrix probe sets: 10553309 (MoGene1.0st)   1415846_a_at (Mouse Genome 430 2.0 Array)   1415847_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000014545
Ensembl peptide - ENSMUSP00000148038
Ensembl peptide - ENSMUSP00000147492
Ensembl peptide - ENSMUSP00000115652
Ensembl peptide - ENSMUSP00000114206
NCBI entrez gene - 16833     See in Manteia.
MGI - MGI:96764
RefSeq - NM_013580
RefSeq - XM_006540681
RefSeq - XM_006540680
RefSeq - XM_006540679
RefSeq Peptide - NP_038608
swissprot - D3YZE4
swissprot - P00342
swissprot - Q548Z6
swissprot - A0A1B0GRE9
swissprot - A0A1B0GSR2
swissprot - D3YVR7
Ensembl - ENSMUSG00000030851
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ldhaENSDARG00000101251Danio rerio
 LDHAENSGALG00000006300Gallus gallus
 LDHCENSG00000166796Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ldha / P06151 / L-lactate dehydrogenase A chain / P00338* / lactate dehydrogenase A*ENSMUSG0000006322972
Ldhb / P16125 / L-lactate dehydrogenase B chain / P07195* / lactate dehydrogenase B*ENSMUSG0000003024665
Ldhal6b / lactate dehydrogenase A like 6B / Q9BYZ2*ENSMUSG0000010195961
Uevld / Q3U1V6 / UEV and lactate/malate dehyrogenase domains / Q8IX04*ENSMUSG0000004326236


Protein motifs (from Interpro)
Interpro ID Name
 IPR001236  Lactate/malate dehydrogenase, N-terminal
 IPR001557  L-lactate/malate dehydrogenase
 IPR011304  L-lactate dehydrogenase
 IPR015955  Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
 IPR018177  L-lactate dehydrogenase, active site
 IPR022383  Lactate/malate dehydrogenase, C-terminal
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006090 pyruvate metabolic process IDA
 biological_processGO:0006754 ATP biosynthetic process IMP
 biological_processGO:0019244 lactate biosynthetic process from pyruvate IDA
 biological_processGO:0019516 lactate oxidation IDA
 biological_processGO:0019752 carboxylic acid metabolic process IEA
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0031514 motile cilium IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004459 L-lactate dehydrogenase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA


Pathways (from Reactome)
Pathway description
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Ggt1-cre)M3Egn/?
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Ggt1-cre)M3Egn/?
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Ggt1-cre)M3Egn/?
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Ggt1-cre)M3Egn/?
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Ggt1-cre)M3Egn/?
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0004884 abnormal testicular physiology "anomaly or loss either the production of male germ cells or the endocrine cells for the production testosterone" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Ggt1-cre)M3Egn/?
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030851 Ldhc / P00342 / lactate dehydrogenase C / P07864*  / complex






 

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