ENSMUSG00000067006


Mus musculus

Features
Gene ID: ENSMUSG00000067006
  
Biological name :Serpinb5
  
Synonyms : P70124 / Serpin B5 / Serpinb5
  
Possible biological names infered from orthology : P36952 / serpin family B member 5
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E2.1
Gene start: 106861173
Gene end: 106883348
  
Corresponding Affymetrix probe sets: 10349108 (MoGene1.0st)   1421752_a_at (Mouse Genome 430 2.0 Array)   1424623_at (Mouse Genome 430 2.0 Array)   1438856_x_at (Mouse Genome 430 2.0 Array)   1441941_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108350
Ensembl peptide - ENSMUSP00000140264
Ensembl peptide - ENSMUSP00000083908
Ensembl peptide - ENSMUSP00000108349
NCBI entrez gene - 20724     See in Manteia.
MGI - MGI:109579
RefSeq - NM_009257
RefSeq Peptide - NP_033283
swissprot - A0A087WQM9
swissprot - P70124
Ensembl - ENSMUSG00000067006
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SERPINB5ENSGALG00000012873Gallus gallus
 P36952ENSG00000206075Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VHP7 / Serpinb1b / serine (or cysteine) peptidase inhibitor, clade B, member 1b / P30740* / SERPINB1* / serpin family B member 1*ENSMUSG0000005102941
Q9D154 / Serpinb1a / serine (or cysteine) peptidase inhibitor, clade B, member 1a / P30740* / SERPINB1* / serpin family B member 1*ENSMUSG0000004473441
Q5SV42 / Serpinb1c / serine (or cysteine) peptidase inhibitor, clade B, member 1c / P30740* / SERPINB1* / serpin family B member 1*ENSMUSG0000007904938
Serpinb6c / serine (or cysteine) peptidase inhibitor, clade B, member 6c / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000005218038
Serpinb6e / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000006924836
Q60854 / Serpinb6a / serine (or cysteine) peptidase inhibitor, clade B, member 6a / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000006014736
Serpinb3b / serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B / P29508* / P48594* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000007360236
Serpinb9e / serine (or cysteine) peptidase inhibitor, clade B, member 9e / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000006234236
Serpinb3a / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000004459436
O08800 / Serpinb8 / Serpin B8 / P50452* / serpin family B member 8*ENSMUSG0000002631536
Serpinb9b / serine (or cysteine) peptidase inhibitor, clade B, member 9b / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000002140335
Q8CDC0 / Serpinb13 / Serpin B13 / Q9UIV8* / serpin family B member 13*ENSMUSG0000004877535
Serpinb6b / serine (or cysteine) peptidase inhibitor, clade B, member 6b / P35237* / SERPINB6* / serpin family B member 6*ENSMUSG0000004284235
Serpinb9g / serine (or cysteine) peptidase inhibitor, clade B, member 9g / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000005772635
Serpinb9f / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000003832735
P12388 / Serpinb2 / serine (or cysteine) peptidase inhibitor, clade B, member 2 / P05120* / serpin family B member 2*ENSMUSG0000006234535
Serpinb3d / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000005801735
Serpinb3c / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4*ENSMUSG0000007360135
Serpinb9d / serine (or cysteine) peptidase inhibitor, clade B, member 9d / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000005426635
Gm11397 / P50453* / SERPINB9* / serpin family B member 9*ENSMUSG0000007145234


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR000240  Serpin B9/maspin
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR033836  Maspin
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002009 morphogenesis of an epithelium IMP
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0050678 regulation of epithelial cell proliferation IMP
 biological_processGO:0060512 prostate gland morphogenesis IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm ISO
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Serpinb5tm1Zha/Serpinb5+
Genetic Background: involves: 129

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Flt3tm1.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm1.1Dosm

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Serpinb5tm1Zha/Serpinb5+
Genetic Background: involves: 129

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011193 embryonic epiblast cell degeneration "a retrogressive impairment of function or destruction of the cells comprising the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012113 decreased inner cell mass proliferation 
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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