ENSMUSG00000069565


Mus musculus

Features
Gene ID: ENSMUSG00000069565
  
Biological name :Dazap1
  
Synonyms : Dazap1 / DAZ-associated protein 1 / Q9JII5
  
Possible biological names infered from orthology : Q96EP5
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 80261486
Gene end: 80288408
  
Corresponding Affymetrix probe sets: 10364752 (MoGene1.0st)   1419275_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000089958
Ensembl peptide - ENSMUSP00000101000
Ensembl peptide - ENSMUSP00000101001
Ensembl peptide - ENSMUSP00000117497
NCBI entrez gene - 70248     See in Manteia.
MGI - MGI:1917498
RefSeq - XM_011243559
RefSeq - NM_001122604
RefSeq - NM_001122605
RefSeq - NM_133188
RefSeq - XM_006514069
RefSeq - XM_006514070
RefSeq - XM_006514071
RefSeq - XM_006514072
RefSeq - XM_006514073
RefSeq - XM_006514074
RefSeq Peptide - NP_001116076
RefSeq Peptide - NP_001116077
RefSeq Peptide - NP_573451
swissprot - Q3UGB5
swissprot - Q9JII5
swissprot - D3Z4J1
Ensembl - ENSMUSG00000069565
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dazap1ENSDARG00000070846Danio rerio
 DAZAP1ENSGALG00000015200Gallus gallus
 DAZAP1ENSG00000071626Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Msi2 / Q920Q6 / RNA-binding 2 / Q96DH6* / musashi RNA binding protein 2*ENSMUSG0000006976930
Msi1 / Q61474 / RNA-binding 1 / O43347* / musashi RNA binding protein 1*ENSMUSG0000005425629
Hnrnpdl / heterogeneous nuclear ribonucleoprotein D like / O14979*ENSMUSG0000002932824
Q99020 / Hnrnpab / Heteroous nuclear ribonucleoprotein A/B / Q99729* / heterogeneous nuclear ribonucleoprotein A/B*ENSMUSG0000002035824
Hnrnpd / Q60668 / Heteroous nuclear ribonucleoprotein D0 / Q14103* / heterogeneous nuclear ribonucleoprotein D*ENSMUSG0000000056822
Q921F2 / Tardbp / TAR DNA binding protein / Q13148*ENSMUSG0000004145920
Rbm31y / predicted, 21379 ENSMUSG0000009536518


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR034131  DAZ-associated protein 1, RNA recognition motif 2
 IPR034134  DAZ-associated protein 1, RNA recognition motif 1
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001893 maternal placenta development IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0048026 positive regulation of mRNA splicing, via spliceosome IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:1990904 ribonucleoprotein complex IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding ISA
 molecular_functionGO:0008266 poly(U) RNA binding IEA
 molecular_functionGO:0034046 poly(G) binding IEA
 molecular_functionGO:0035613 RNA stem-loop binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Dazap1tm1.2Pyen/Dazap1tm1.2Pyen
Genetic Background: involves: 129S6/SvEvTac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dazap1tm1.2Pyen/Dazap1tm1.2Pyen
Genetic Background: involves: 129S6/SvEvTac

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Dazap1tm1.2Pyen/Dazap1tm1.2Pyen
Genetic Background: involves: 129S6/SvEvTac

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002685 abnormal proliferation of spermatogonia "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0009661 abnormal pregnancy "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0011112 partial lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Dazap1tm1.2Pyen/Dazap1tm1.2Pyen
Genetic Background: involves: 129S6/SvEvTac

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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