ENSMUSG00000069769


Mus musculus

Features
Gene ID: ENSMUSG00000069769
  
Biological name :Msi2
  
Synonyms : Msi2 / Q920Q6 / RNA-binding 2
  
Possible biological names infered from orthology : musashi RNA binding protein 2 / Q96DH6
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: C
Gene start: 88339382
Gene end: 88718513
  
Corresponding Affymetrix probe sets: 10389680 (MoGene1.0st)   1421230_a_at (Mouse Genome 430 2.0 Array)   1421231_at (Mouse Genome 430 2.0 Array)   1435520_at (Mouse Genome 430 2.0 Array)   1435521_at (Mouse Genome 430 2.0 Array)   1436818_a_at (Mouse Genome 430 2.0 Array)   1441185_at (Mouse Genome 430 2.0 Array)   1443008_at (Mouse Genome 430 2.0 Array)   1458136_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119684
Ensembl peptide - ENSMUSP00000090470
Ensembl peptide - ENSMUSP00000103541
Ensembl peptide - ENSMUSP00000103542
NCBI entrez gene - 76626     See in Manteia.
MGI - MGI:1923876
RefSeq - XM_017314830
RefSeq - XM_006534438
RefSeq - XM_006534439
RefSeq - XM_006534440
RefSeq - XM_006534441
RefSeq - XM_006534442
RefSeq - XM_011249302
RefSeq - XM_011249304
RefSeq - NM_001201341
RefSeq - NM_054043
RefSeq - XM_006534431
RefSeq - XM_006534432
RefSeq - XM_006534434
RefSeq - XM_006534435
RefSeq Peptide - NP_001188270
RefSeq Peptide - NP_473384
swissprot - B1AT10
swissprot - B1AT13
swissprot - Q3TE41
swissprot - Q2M2Q8
swissprot - Q920Q6
Ensembl - ENSMUSG00000069769
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 msi2aENSDARG00000033901Danio rerio
 msi2bENSDARG00000032614Danio rerio
 MSI2ENSGALG00000005567Gallus gallus
 MSI2ENSG00000153944Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Msi1 / Q61474 / RNA-binding 1 / O43347* / musashi RNA binding protein 1*ENSMUSG0000005425672
Hnrnpdl / heterogeneous nuclear ribonucleoprotein D like / O14979*ENSMUSG0000002932836
Dazap1 / Q9JII5 / DAZ-associated protein 1 / Q96EP5*ENSMUSG0000006956535
Hnrnpd / Q60668 / Heteroous nuclear ribonucleoprotein D0 / Q14103* / heterogeneous nuclear ribonucleoprotein D*ENSMUSG0000000056834
Q99020 / Hnrnpab / Heteroous nuclear ribonucleoprotein A/B / Q99729* / heterogeneous nuclear ribonucleoprotein A/B*ENSMUSG0000002035834
Rbm31y / predicted, 21379 ENSMUSG0000009536527
Q921F2 / Tardbp / TAR DNA binding protein / Q13148*ENSMUSG0000004145925


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR034126  RNA-binding protein Musashi homologue, RNA recognition motif 2
 IPR034130  RNA-binding protein Musashi homologue, RNA recognition motif 1
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0048864 stem cell development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005844 polysome IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IDA
 molecular_functionGO:0008266 poly(U) RNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

Allelic Composition: Msi2tm1.1Cjl/Msi2tm1.1Cjl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Msi2Gt(E035H03)Wrst/Msi2Gt(E035H03)Wrst
Genetic Background: B6.129P2-Msi2Gt(E035H03)Wrst

Allelic Composition: Msi2tm1.1Cjl/Msi2tm1.1Cjl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msi2tm1.1Cjl/Msi2tm1.1Cjl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msi2Gt(E035H03)Wrst/Msi2Gt(E035H03)Wrst
Genetic Background: B6.129P2-Msi2Gt(E035H03)Wrst

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msi2Gt(E035H03)Wrst/Msi2Gt(E035H03)Wrst
Genetic Background: B6.129P2-Msi2Gt(E035H03)Wrst

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msi2Gt(E035H03)Wrst/Msi2Gt(E035H03)Wrst
Genetic Background: B6.129P2-Msi2Gt(E035H03)Wrst

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Msi2Gt(E035H03)Wrst/Msi2Gt(E035H03)Wrst
Genetic Background: B6.129P2-Msi2Gt(E035H03)Wrst

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msi2Gt(E035H03)Wrst/Msi2Gt(E035H03)Wrst
Genetic Background: B6.129P2-Msi2Gt(E035H03)Wrst

 MP:0008249 abnormal common lymphocyte progenitor cell morphology "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
Show

Allelic Composition: Msi2Gt(E035H03)Wrst/Msi2Gt(E035H03)Wrst
Genetic Background: B6.129P2-Msi2Gt(E035H03)Wrst

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
Show

Allelic Composition: Msi2Gt(E035H03)Wrst/Msi2Gt(E035H03)Wrst
Genetic Background: B6.129P2-Msi2Gt(E035H03)Wrst

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msi2Gt(E035H03)Wrst/Msi2Gt(E035H03)Wrst
Genetic Background: B6.129P2-Msi2Gt(E035H03)Wrst

 MP:0010132 decreased DN2 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive" [CL:0000806]
Show

Allelic Composition: Msi2Gt(E035H03)Wrst/Msi2Gt(E035H03)Wrst
Genetic Background: B6.129P2-Msi2Gt(E035H03)Wrst

 MP:0010134 decreased DN3 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
Show

Allelic Composition: Msi2Gt(E035H03)Wrst/Msi2Gt(E035H03)Wrst
Genetic Background: B6.129P2-Msi2Gt(E035H03)Wrst

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msi2Gt(E035H03)Wrst/Msi2Gt(E035H03)Wrst
Genetic Background: B6.129P2-Msi2Gt(E035H03)Wrst

Allelic Composition: Msi2tm1.1Cjl/Msi2tm1.1Cjl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Msi2Gt(E035H03)Wrst/Msi2Gt(E035H03)Wrst
Genetic Background: B6.129P2-Msi2Gt(E035H03)Wrst

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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