ENSMUSG00000041459


Mus musculus

Features
Gene ID: ENSMUSG00000041459
  
Biological name :Tardbp
  
Synonyms : Q921F2 / Tardbp / TAR DNA binding protein
  
Possible biological names infered from orthology : Q13148
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 148612382
Gene end: 148627019
  
Corresponding Affymetrix probe sets: 10518532 (MoGene1.0st)   1423723_s_at (Mouse Genome 430 2.0 Array)   1428467_at (Mouse Genome 430 2.0 Array)   1434419_s_at (Mouse Genome 430 2.0 Array)   1436318_at (Mouse Genome 430 2.0 Array)   1455655_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140529
Ensembl peptide - ENSMUSP00000139547
Ensembl peptide - ENSMUSP00000139637
Ensembl peptide - ENSMUSP00000140057
Ensembl peptide - ENSMUSP00000140110
Ensembl peptide - ENSMUSP00000140333
Ensembl peptide - ENSMUSP00000140364
Ensembl peptide - ENSMUSP00000140385
Ensembl peptide - ENSMUSP00000140718
Ensembl peptide - ENSMUSP00000141052
Ensembl peptide - ENSMUSP00000141010
Ensembl peptide - ENSMUSP00000140989
Ensembl peptide - ENSMUSP00000140928
Ensembl peptide - ENSMUSP00000140859
Ensembl peptide - ENSMUSP00000140832
Ensembl peptide - ENSMUSP00000038113
Ensembl peptide - ENSMUSP00000081142
Ensembl peptide - ENSMUSP00000093386
Ensembl peptide - ENSMUSP00000101324
Ensembl peptide - ENSMUSP00000101325
Ensembl peptide - ENSMUSP00000101327
Ensembl peptide - ENSMUSP00000129342
Ensembl peptide - ENSMUSP00000130963
Ensembl peptide - ENSMUSP00000135135
Ensembl peptide - ENSMUSP00000139476
NCBI entrez gene - 230908     See in Manteia.
MGI - MGI:2387629
RefSeq - NM_001305425
RefSeq - NM_001008546
RefSeq - NM_001008545
RefSeq - NM_001003899
RefSeq - NM_001003898
RefSeq - NM_145556
RefSeq Peptide - NP_001292354
RefSeq Peptide - NP_001003898
RefSeq Peptide - NP_001003899
RefSeq Peptide - NP_001008545
RefSeq Peptide - NP_001008546
RefSeq Peptide - NP_663531
swissprot - A0A087WRZ5
swissprot - H3BJV1
swissprot - A0A087WRP4
swissprot - A0A087WR97
swissprot - A0A087WQX8
swissprot - A0A087WQT4
swissprot - A0A087WQA5
swissprot - A0A087WQ63
swissprot - A0A087WP57
swissprot - Q6VYI4
swissprot - Q6VYI5
swissprot - Q8BLD4
swissprot - Q8R0B4
swissprot - A0A087WNY6
swissprot - Q921F2
swissprot - Q544R5
swissprot - A0A087WSH7
swissprot - A0A087WSE4
swissprot - A0A087WSC6
swissprot - A0A087WS74
swissprot - A0A087WS17
Ensembl - ENSMUSG00000041459
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tardbpENSDARG00000040031Danio rerio
 tardbplENSDARG00000004452Danio rerio
 TARDBPENSGALG00000002906Gallus gallus
 Q13148ENSG00000120948Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hnrnpdl / heterogeneous nuclear ribonucleoprotein D like / O14979*ENSMUSG0000002932823
Hnrnpd / Q60668 / Heteroous nuclear ribonucleoprotein D0 / Q14103* / heterogeneous nuclear ribonucleoprotein D*ENSMUSG0000000056823
Msi1 / Q61474 / RNA-binding 1 / O43347* / musashi RNA binding protein 1*ENSMUSG0000005425621
Msi2 / Q920Q6 / RNA-binding 2 / Q96DH6* / musashi RNA binding protein 2*ENSMUSG0000006976921
Q99020 / Hnrnpab / Heteroous nuclear ribonucleoprotein A/B / Q99729* / heterogeneous nuclear ribonucleoprotein A/B*ENSMUSG0000002035821
Dazap1 / Q9JII5 / DAZ-associated protein 1 / Q96EP5*ENSMUSG0000006956520
Rbm31y / predicted, 21379 ENSMUSG0000009536519


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing ISO
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043922 negative regulation by host of viral transcription IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0070935 3"-UTR-mediated mRNA stabilization IEA
 biological_processGO:0071765 nuclear inner membrane organization ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Tardbptm1.1Ckjs/Tardbptm1.2Cjks
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Tardbptm1.1Ckjs/Tardbptm1.2Cjks
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Tardbptm1.1Ckjs/Tardbptm1.2Cjks
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Tardbptm1.1Ckjs/Tardbptm1.2Cjks
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mbpshi/Mbpshi,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: C3HeB/Fe * C57BL/6 * CBA * SWV

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbp+
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Tardbptm1.1Pcw/Tardbp+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Tardbptm1.1Pcw/Tardbptm1.1Pcw,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Tardbptm1.1Ckjs/Tardbptm1.2Cjks
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Tardbpm1H/Tardbp+,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: C3H/HeH * C57BL/6 * C57BL/6J * SJL

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbptm1.1Pcw
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Tardbptm1.1Ckjs/Tardbptm1.2Cjks
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Tardbptm1.1Ckjs/Tardbptm1.2Cjks
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh23m1Btlr/Cdh23m1Btlr
Genetic Background: C57BL/6J-Cdh23m1Btlr

Allelic Composition: Tardbpm1H/Tardbp+
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pclotm1.1Mver/Pclotm1.1Mver
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh23m1Btlr/Cdh23m1Btlr
Genetic Background: C57BL/6J-Cdh23m1Btlr

Allelic Composition: Tardbpm1H/Tardbp+,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: C3H/HeH * C57BL/6 * C57BL/6J * SJL

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Tardbptm1.1Ckjs/Tardbptm1.2Cjks
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tardbptm1.1Pcw/Tardbptm1.1Pcw,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0003157 impaired muscle relaxation "reduced or absent ability of muscle to lengthen following contractions" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92510]
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Allelic Composition: Tardbpm1H/Tardbp+
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Tardbpm1H/Tardbp+,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: C3H/HeH * C57BL/6 * C57BL/6J * SJL

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Tardbptm1.1Ckjs/Tardbptm1.2Cjks
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004129 abnormal respiratory quotient "anomaly in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism" [J:94416]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbptm1.1Pcw
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbp+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004142 abnormal muscle tone "anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Tardbpm1H/Tardbp+
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Tardbpm1H/Tardbp+,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: C3H/HeH * C57BL/6 * C57BL/6J * SJL

 MP:0005112 abnormal anterior horn morphology "anomalous structure of the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Tardbptm1.1Ckjs/Tardbptm1.2Cjks
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbptm1.1Pcw
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pclotm1.1Mver/Pclotm1.1Mver
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0009116 abnormal brown fat cell morphology "any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]
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Allelic Composition: Tardbptm1.1Pcw/Tardbp+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Tardbptm1.1Pcw/Tardbptm1.1Pcw,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0009117 abnormal white fat cell morphology "any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]
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Allelic Composition: Tardbptm1.1Pcw/Tardbp+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Tardbptm1.1Pcw/Tardbptm1.1Pcw,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0009299 decreased mesenteric fat pad weight 
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Allelic Composition: Tardbptm1.1Pcw/Tardbptm1.1Pcw,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0009424 decreased extensor digitorum longus weight "reduction in the weight of the penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tardbpm1H/Tardbp+,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: C3H/HeH * C57BL/6 * C57BL/6J * SJL

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbptm1.1Pcw
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbp+
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Tardbptm1.1Pcw/Tardbptm1.1Pcw,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: T2J/T+
Genetic Background: C57BL/6J-T2J/J

Allelic Composition: Tardbpm1H/Tardbp+,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: C3H/HeH * C57BL/6 * C57BL/6J * SJL

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbptm1.1Pcw
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0010951 abnormal lipid oxidation "anomaly in the process of removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0034440]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbptm1.1Pcw
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Tardbptm1.1Pcw/Tardbptm1.1Pcw,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mbpshi/Mbpshi,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: C3HeB/Fe * C57BL/6 * CBA * SWV

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: G6pctm2.2Jyc/G6pctm2.2Jyc
Genetic Background: involves:129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N

Allelic Composition: Tardbpm1H/Tardbpm1H
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Slc17a6tm1Lowl/Slc17a6tm1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0012114 absent inner cell mass proliferation 
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Allelic Composition: G6pctm2.2Jyc/G6pctm2.2Jyc
Genetic Background: involves:129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Rspo3tm1Arte/Rspo3tm1Arte,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tardbptm1b(EUCOMM)Wtsi/Tardbptm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tardbptm1b(EUCOMM)Wtsi/H

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Tardbptm1b(EUCOMM)Wtsi/Tardbptm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tardbptm1b(EUCOMM)Wtsi/H

 MP:0020448 increased microglial cell activation "increase in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Tardbptm1.1Ckjs/Tardbptm1.2Cjks
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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