ENSMUSG00000000568


Mus musculus

Features
Gene ID: ENSMUSG00000000568
  
Biological name :Hnrnpd
  
Synonyms : Heteroous nuclear ribonucleoprotein D0 / Hnrnpd / Q60668
  
Possible biological names infered from orthology : heterogeneous nuclear ribonucleoprotein D / Q14103
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E4
Gene start: 99955935
Gene end: 99978938
  
Corresponding Affymetrix probe sets: 10531633 (MoGene1.0st)   1425142_a_at (Mouse Genome 430 2.0 Array)   1457568_at (Mouse Genome 430 2.0 Array)   1458273_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131859
Ensembl peptide - ENSMUSP00000131785
Ensembl peptide - ENSMUSP00000132735
Ensembl peptide - ENSMUSP00000143218
Ensembl peptide - ENSMUSP00000019128
Ensembl peptide - ENSMUSP00000072533
Ensembl peptide - ENSMUSP00000108561
Ensembl peptide - ENSMUSP00000125984
Ensembl peptide - ENSMUSP00000127833
Ensembl peptide - ENSMUSP00000131262
NCBI entrez gene - 11991     See in Manteia.
MGI - MGI:101947
RefSeq - XM_006534735
RefSeq - NM_001077265
RefSeq - NM_001077266
RefSeq - NM_001077267
RefSeq - NM_007516
RefSeq Peptide - NP_001070735
RefSeq Peptide - NP_031542
RefSeq Peptide - NP_001070733
RefSeq Peptide - NP_001070734
swissprot - A0A0G2JFL4
swissprot - E9Q5B6
swissprot - F6SHF3
swissprot - F6ZV59
swissprot - G3X9W0
swissprot - F7A465
swissprot - G5E8G0
swissprot - E9Q4W5
swissprot - Q60668
Ensembl - ENSMUSG00000000568
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hnrnpdENSDARG00000059246Danio rerio
 HNRNPDENSGALG00000011184Gallus gallus
 HNRNPDENSG00000138668Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99020 / Hnrnpab / Heteroous nuclear ribonucleoprotein A/B / Q99729* / heterogeneous nuclear ribonucleoprotein A/B*ENSMUSG0000002035861
Hnrnpdl / heterogeneous nuclear ribonucleoprotein D like / O14979*ENSMUSG0000002932857
Rbm31y / predicted, 21379 ENSMUSG0000009536535
Msi2 / Q920Q6 / RNA-binding 2 / Q96DH6* / musashi RNA binding protein 2*ENSMUSG0000006976933
Msi1 / Q61474 / RNA-binding 1 / O43347* / musashi RNA binding protein 1*ENSMUSG0000005425630
Q921F2 / Tardbp / TAR DNA binding protein / Q13148*ENSMUSG0000004145927
Dazap1 / Q9JII5 / DAZ-associated protein 1 / Q96EP5*ENSMUSG0000006956526


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR012956  CARG-binding factor, N-terminal
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0032204 regulation of telomere maintenance IMP
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0043488 regulation of mRNA stability IMP
 biological_processGO:0045727 positive regulation of translation ISO
 biological_processGO:0048255 mRNA stabilization IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0061158 3"-UTR-mediated mRNA destabilization IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071732 cellular response to nitric oxide IEA
 biological_processGO:0097167 circadian regulation of translation ISO
 biological_processGO:1901355 response to rapamycin IEA
 biological_processGO:1904355 positive regulation of telomere capping IMP
 biological_processGO:1904383 response to sodium phosphate IEA
 biological_processGO:1904586 cellular response to putrescine IEA
 biological_processGO:1905663 positive regulation of telomerase RNA reverse transcriptase activity IMP
 biological_processGO:1990828 hepatocyte dedifferentiation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003680 AT DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0035925 mRNA 3"-UTR AU-rich region binding IEA
 molecular_functionGO:0042162 telomeric DNA binding ISS
 molecular_functionGO:0042826 histone deacetylase binding IEA


Pathways (from Reactome)
Pathway description
AUF1 (hnRNP D0) binds and destabilizes mRNA
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0000533 kidney hemorrhage "bleeding in the organ of excretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000568 Hnrnpd / Q60668 / Heteroous nuclear ribonucleoprotein D0 / Q14103* / heterogeneous nuclear ribonucleoprotein D*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr