| MP:0000186 | decreased circulating HDL cholesterol level | "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0000189 | hypoglycemia | "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0000527 | abnormal kidney development | "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0000601 | small liver | "reduced size of the liver" [J:23170] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0000603 | pale liver | "liver lacking normal coloration, often refers to bloodless condition" [J:18048] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0000704 | abnormal thymus development | "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0001780 | decreased brown fat amount | "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0002644 | decreased circulating triglyceride level | "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0002891 | increased insulin sensitivity | "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0002941 | increased circulating alanine transaminase level | "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0002968 | increased circulating alkaline phosphatase level | "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0003887 | increased hepatocyte apoptosis | "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0003943 | abnormal liver/biliary system development | "developmental anomaly of any of the tissues of the liver or biliary system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0004701 | decreased circulating insulin-like growth factor I level | "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0005017 | decreased B cell number | "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Srsf3tm1Pjln/Srsf3tm1Pjln
Genetic Background: involves: 129P2/OlaHsd * BALB/c
Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129P2/OlaHsd * BALB/c
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| MP:0005123 | increased circulating growth hormone level | "greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0005179 | decreased total circulating cholesterol level | "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0005291 | abnormal glucose tolerance | "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0005343 | increased circulating aspartate transaminase level | "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204] |
Show
Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0005344 | increased circulating bilirubin level | "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204] |
Show
Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0005419 | hypoalbuminemia | "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0005659 | resistance to diet-induced obesity | "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0008208 | decreased pro-B cell number | "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129P2/OlaHsd * BALB/c
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| MP:0008209 | decreased pre-B cell number | "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129P2/OlaHsd * BALB/c
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| MP:0008989 | abnormal liver sinusoid morphology | "any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0008991 | abnormal bile canaliculus morphology | "any structural anomaly of the intercellular channels that take up bile from hepatocytes and transport it to the bile ducts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0009356 | decreased liver triglyceride level | "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0009378 | abnormal endoplasmic reticulum morphology | "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0009781 | abnormal preimplantation embryo development | "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0010026 | decreased liver cholesterol level | "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0010398 | decreased liver glycogen level | "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0011094 | complete embryonic lethality before implantation | "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith] |
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0012129 | failure of blastocyst formation | "inability to form a blastocyst from a solid ball of cells known as a morula" [MGI:anna] |
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0014172 | decreased fatty acid oxidation | |
Show
Allelic Composition: Srsf3tm1Pjln/Srsf3tm1Pjln,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: BALB/c * C57BL/6 * DBA
|
