ENSMUSG00000094936


Mus musculus

Features
Gene ID: ENSMUSG00000094936
  
Biological name :Rbm4
  
Synonyms : Q8C7Q4 / Rbm4 / RNA binding motif protein 4
  
Possible biological names infered from orthology : Q9BWF3
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 4784293
Gene end: 4793901
  
Corresponding Affymetrix probe sets: 10464813 (MoGene1.0st)   1416920_at (Mouse Genome 430 2.0 Array)   1437322_at (Mouse Genome 430 2.0 Array)   1455517_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129745
Ensembl peptide - ENSMUSP00000137174
Ensembl peptide - ENSMUSP00000137345
Ensembl peptide - ENSMUSP00000127564
Ensembl peptide - ENSMUSP00000136254
NCBI entrez gene - 19653     See in Manteia.
MGI - MGI:1100865
RefSeq - NM_001290123
RefSeq - NM_001290122
RefSeq - NM_001290124
RefSeq - NM_001290125
RefSeq - NM_009032
RefSeq Peptide - NP_033058
RefSeq Peptide - NP_001277051
RefSeq Peptide - NP_001277052
RefSeq Peptide - NP_001277053
RefSeq Peptide - NP_001277054
swissprot - B7ZN14
swissprot - Q5CZX8
swissprot - Q8C7Q4
swissprot - J3QPA9
swissprot - F6TBN8
Ensembl - ENSMUSG00000094936
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6IQ97ENSDARG00000036386Danio rerio
 rbm4.2ENSDARG00000055080Danio rerio
 rbm4.3ENSDARG00000022129Danio rerio
 RBM4ENSG00000173933Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm21992 / RBM4* / Q9BWF3* / RNA binding motif protein 4*ENSMUSG00000096370100
Rbm4b / Q8VE92 / RNA-binding protein 4B / Q9BQ04* / RNA binding motif protein 4B*ENSMUSG0000003376086
Rbm14 / Q8C2Q3 / RNA-binding protein 14 / Q96PK6* / RNA binding motif protein 14*ENSMUSG0000000645632


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR001878  Zinc finger, CCHC-type
 IPR034897  RBM4, RNA recognition motif 1
 IPR034898  RBM4, RNA recognition motif 2
 IPR035979  RNA-binding domain superfamily
 IPR036875  Zinc finger, CCHC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome ISO
 biological_processGO:0002190 cap-independent translational initiation ISO
 biological_processGO:0002192 IRES-dependent translational initiation of linear mRNA ISO
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0017148 negative regulation of translation ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0032055 negative regulation of translation in response to stress ISO
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0035278 miRNA mediated inhibition of translation ISO
 biological_processGO:0035773 insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0035883 enteroendocrine cell differentiation IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IDA
 biological_processGO:0045727 positive regulation of translation IDA
 biological_processGO:0045947 negative regulation of translational initiation ISO
 biological_processGO:0046626 regulation of insulin receptor signaling pathway IDA
 biological_processGO:0046685 response to arsenic-containing substance ISS
 biological_processGO:0046822 regulation of nucleocytoplasmic transport IDA
 biological_processGO:0051149 positive regulation of muscle cell differentiation ISS
 biological_processGO:0097167 circadian regulation of translation IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0010494 cytoplasmic stress granule ISS
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding ISO
 molecular_functionGO:0003730 mRNA 3"-UTR binding IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0030332 cyclin binding ISO
 molecular_functionGO:0035198 miRNA binding ISS
 molecular_functionGO:0036002 pre-mRNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097157 pre-mRNA intronic binding ISS
 molecular_functionGO:0097158 pre-mRNA intronic pyrimidine-rich binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Atxn2tm2.1Geno/Atxn2tm2.1Geno
Genetic Background: B6.129S2-Atxn2tm2.1Geno

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atxn2tm2.1Geno/Atxn2tm2.1Geno
Genetic Background: B6.129S2-Atxn2tm2.1Geno

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atxn2tm2.1Geno/Atxn2tm2.1Geno
Genetic Background: B6.129S2-Atxn2tm2.1Geno

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atxn2tm2.1Geno/Atxn2tm2.1Geno
Genetic Background: B6.129S2-Atxn2tm2.1Geno

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atxn2tm2.1Geno/Atxn2tm2.1Geno
Genetic Background: B6.129S2-Atxn2tm2.1Geno

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Atxn2tm2.1Geno/Atxn2tm2.1Geno
Genetic Background: B6.129S2-Atxn2tm2.1Geno

 MP:0010147 abnormal endocrine pancreas physiology "any functional anomaly of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atxn2tm2.1Geno/Atxn2tm2.1Geno
Genetic Background: B6.129S2-Atxn2tm2.1Geno

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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