ENSMUSG00000109511


Mus musculus

Features
Gene ID: ENSMUSG00000109511
  
Biological name :Nup62
  
Synonyms : Nuclear pore glycoprotein p62 / Nup62 / Q63850
  
Possible biological names infered from orthology : nucleoporin 62 / P37198
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 44816088
Gene end: 44830812
  
Corresponding Affymetrix probe sets: 10552740 (MoGene1.0st)   1415925_a_at (Mouse Genome 430 2.0 Array)   1415926_at (Mouse Genome 430 2.0 Array)   1438917_x_at (Mouse Genome 430 2.0 Array)   1447905_x_at (Mouse Genome 430 2.0 Array)   1448150_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147109
Ensembl peptide - ENSMUSP00000147215
Ensembl peptide - ENSMUSP00000147181
Ensembl peptide - ENSMUSP00000056785
Ensembl peptide - ENSMUSP00000146695
NCBI entrez gene - 18226     See in Manteia.
MGI - MGI:1351500
RefSeq - NM_053074
RefSeq Peptide - NP_444304
swissprot - A0A140LJ77
swissprot - A0A140LJH5
swissprot - Q5FWJ9
swissprot - Q63850
Ensembl - ENSMUSG00000109511
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nup62lENSDARG00000020527Danio rerio
 ENSGALG00000004856Gallus gallus
 NUP62ENSG00000213024Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nup62cl / Q9H1M0* / nucleoporin 62 C-terminal like*ENSMUSG0000007294423


Protein motifs (from Interpro)
Interpro ID Name
 IPR007758  Nucleoporin, NSP1-like, C-terminal
 IPR026010  Nucleoporin NSP1/NUP62
 IPR033072  Nuclear pore glycoprotein p62, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006351 transcription, DNA-templated ISO
 biological_processGO:0006606 protein import into nucleus IBA
 biological_processGO:0006913 nucleocytoplasmic transport IEA
 biological_processGO:0007080 mitotic metaphase plate congression ISO
 biological_processGO:0007098 centrosome cycle ISO
 biological_processGO:0007100 mitotic centrosome separation ISO
 biological_processGO:0007166 cell surface receptor signaling pathway ISS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007569 cell aging IDA
 biological_processGO:0008219 cell death ISO
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016477 cell migration NAS
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0042306 regulation of protein import into nucleus IEA
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043069 negative regulation of programmed cell death ISS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0043407 negative regulation of MAP kinase activity IMP
 biological_processGO:0045840 positive regulation of mitotic nuclear division ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IMP
 biological_processGO:0046601 positive regulation of centriole replication ISO
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051169 nuclear transport IEA
 biological_processGO:0060236 regulation of mitotic spindle organization ISO
 biological_processGO:0070208 protein heterotrimerization IEA
 biological_processGO:0071426 ribonucleoprotein complex export from nucleus IBA
 biological_processGO:0098534 centriole assembly ISO
 biological_processGO:1903438 positive regulation of mitotic cytokinetic process ISO
 biological_processGO:1904781 positive regulation of protein localization to centrosome ISO
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005642 annulate lamellae IEA
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0031965 nuclear membrane ISO
 cellular_componentGO:0044613 nuclear pore central transport channel IBA
 cellular_componentGO:0072686 mitotic spindle ISO
 cellular_componentGO:0090543 Flemming body ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IBA
 molecular_functionGO:0017056 structural constituent of nuclear pore IEA
 molecular_functionGO:0019894 kinesin binding IEA
 molecular_functionGO:0030159 receptor signaling complex scaffold activity ISO
 molecular_functionGO:0030544 Hsp70 protein binding IDA
 molecular_functionGO:0042169 SH2 domain binding ISO
 molecular_functionGO:0043130 ubiquitin binding ISS
 molecular_functionGO:0046966 thyroid hormone receptor binding ISS
 molecular_functionGO:0051425 PTB domain binding IPI
 molecular_functionGO:0051879 Hsp90 protein binding IDA


Pathways (from Reactome)
Pathway description
Transport of Mature mRNA derived from an Intron-Containing Transcript
Regulation of Glucokinase by Glucokinase Regulatory Protein
snRNP Assembly
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000114797 Nupl1 / Q8R332 / Nucleoporin p58/p45 / NUP58* / Q9BVL2* / nucleoporin 58*  / complex
 ENSMUSG00000034826 Nup54 / Q8BTS4 / Nuclear pore complex protein Nup54 / Q7Z3B4* / nucleoporin 54*  / complex
 ENSMUSG00000109511 Nup62 / Q63850 / Nuclear pore glycoprotein p62 / P37198* / nucleoporin 62*  / complex






 

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