ENSDARG00000009922


Danio rerio

Features
Gene ID: ENSDARG00000009922
  
Biological name :dmbx1a
  
Synonyms : diencephalon/mesencephalon homeobox 1a / dmbx1a / Q8JI10
  
Possible biological names infered from orthology : diencephalon/mesencephalon homeobox 1 / Diencephalon/mesencephalon homeobox protein 1 / DMBX1 / Q8NFW5 / Q91ZK4
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 10183640
Gene end: 10192487
  
Corresponding Affymetrix probe sets: Dr.18845.1.S1_at (Zebrafish Array)   Dr.18845.1.S2_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000106835
Ensembl peptide - ENSDARP00000027577
Ensembl peptide - ENSDARP00000148506
NCBI entrez gene - 142987     See in Manteia.
swissprot - A4IG24
swissprot - Q8JI10
ZFIN ID - ZDB-GENE-020117-1
Ensembl - ENSDARG00000009922
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DMBX1ENSGALG00000010436Gallus gallus
 DMBX1ENSG00000197587Homo sapiens
 Dmbx1ENSMUSG00000028707Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dmbx1b / Q566X8 / diencephalon/mesencephalon homeobox 1b / DMBX1* / Q8NFW5* / diencephalon/mesencephalon homeobox 1*ENSDARG0000000251071
zgc:101100ENSDARG0000002195926
otx5 / orthodenticle homolog 5ENSDARG0000004348322
otx2b / Q91981 / orthodenticle homeobox 2b / OTX2* / P32243* / orthodenticle homeobox 2*ENSDARG0000001123521
crx / cone-rod homeoboxENSDARG0000001198920
pitx2 / Q9W5Z2 / paired-like homeodomain 2 / P97474* / Q99697* / paired-like homeodomain transcription factor 2*ENSDARG0000003619420
pitx3 / Q6QU75 / paired-like homeodomain 3ENSDARG0000007006920
pitx1 / paired-like homeodomain 1 / PITX3* / P78337* / O75364* / paired like homeodomain 3*ENSDARG0000011660820
otx2a / Q90267 / orthodenticle homeobox 2aENSDARG0000003070319
otx1 / Q91994 / orthodenticle homeobox 1 / P32242* / P80205* / Homeobox protein OTX1 *ENSDARG0000009499219
prrx1a / paired related homeobox 1a / PRRX1* / P63013* / P54821* / paired related homeobox 1* / Paired mesoderm homeobox protein 1 *ENSDARG0000003397117
prrx1b / paired related homeobox 1b / PRRX1* / P63013* / P54821* / paired related homeobox 1* / Paired mesoderm homeobox protein 1 *ENSDARG0000004202716
mixl1 / Mix paired-like homeobox / Q9H2W2* / Q9WUI0* / Homeobox protein MIXL1 *ENSDARG0000006925214
pax10 / paired box 10ENSDARG0000005336413
gsc / goosecoid / P56915* / Q02591* / goosecoid homeobox* / Homeobox protein goosecoid *ENSDARG0000005907312


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003654  OAR domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IEP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IGI
 biological_processGO:0007420 brain development IEP
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0050767 regulation of neurogenesis IMP
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0061074 regulation of neural retina development IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens decreased size , abnormal
Show

 ZFA:0000152 retina retina decreased thickness , abnormal
retina absent , abnormal
retina increased amount , abnormal
retina central region amount , ameliorated
retina central region increased amount , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II defasciculated , abnormal
Show

 ZFA:0000445 optic tectum optic tectum decreased size , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell amount , ameliorated
retinal ganglion cell absent , ameliorated
retinal ganglion cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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