ENSDARG00000069252


Danio rerio

Features
Gene ID: ENSDARG00000069252
  
Biological name :mixl1
  
Synonyms : mixl1 / Mix paired-like homeobox
  
Possible biological names infered from orthology : Homeobox protein MIXL1 / Q9H2W2 / Q9WUI0
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 43715157
Gene end: 43723860
  
Corresponding Affymetrix probe sets: Dr.8084.1.S1_at (Zebrafish Array)   NM_130940_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000108258
NCBI entrez gene - 30115     See in Manteia.
RefSeq - NM_130940
RefSeq Peptide - NP_571015
swissprot - Q5TYX1
ZFIN ID - ZDB-GENE-000208-20
Ensembl - ENSDARG00000069252
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MIXL1ENSG00000185155Homo sapiens
 Mixl1ENSMUSG00000026497Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
otx5 / orthodenticle homolog 5ENSDARG0000004348318
otx2b / Q91981 / orthodenticle homeobox 2b / OTX2* / P32243* / orthodenticle homeobox 2*ENSDARG0000001123517
otx2a / Q90267 / orthodenticle homeobox 2aENSDARG0000003070317
otx1 / Q91994 / orthodenticle homeobox 1 / P32242* / P80205* / Homeobox protein OTX1 *ENSDARG0000009499217
Q8JI10 / dmbx1a / diencephalon/mesencephalon homeobox 1a / DMBX1* / Q91ZK4* / Q8NFW5* / diencephalon/mesencephalon homeobox 1* / Diencephalon/mesencephalon homeobox protein 1 *ENSDARG0000000992216
crx / cone-rod homeoboxENSDARG0000001198916
dmbx1b / Q566X8 / diencephalon/mesencephalon homeobox 1b / DMBX1* / Q8NFW5* / diencephalon/mesencephalon homeobox 1*ENSDARG0000000251015
pitx3 / Q6QU75 / paired-like homeodomain 3ENSDARG0000007006915
pitx1 / paired-like homeodomain 1 / PITX3* / P78337* / O75364* / paired like homeodomain 3*ENSDARG0000011660815
zgc:101100ENSDARG0000002195914
pitx2 / Q9W5Z2 / paired-like homeodomain 2 / P97474* / Q99697* / paired-like homeodomain transcription factor 2*ENSDARG0000003619414
pax10 / paired box 10ENSDARG0000005336413
prrx1a / paired related homeobox 1a / PRRX1* / P63013* / P54821* / paired related homeobox 1* / Paired mesoderm homeobox protein 1 *ENSDARG0000003397112
prrx1b / paired related homeobox 1b / PRRX1* / P63013* / P54821* / paired related homeobox 1* / Paired mesoderm homeobox protein 1 *ENSDARG0000004202711
gsc / goosecoid / P56915* / Q02591* / goosecoid homeobox* / Homeobox protein goosecoid *ENSDARG0000005907310


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001706 endoderm formation IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0007492 endoderm development IGI
 biological_processGO:0009880 embryonic pattern specification IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
Show

 ZFA:0000017 endoderm endoderm endodermal cell decreased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000071 shield shield poorly differentiated , abnormal
Show

 ZFA:0000084 yolk yolk increased size , abnormal
Show

 ZFA:0000106 extension extension increased thickness , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle collapsed , abnormal
Show

 ZFA:0000111 germ ring germ ring poorly differentiated , abnormal
Show

 ZFA:0000112 gut gut aplastic , abnormal
Show

 ZFA:0000114 heart heart cleft , abnormal
heart duplicated , abnormal
heart morphology , abnormal
heart quality , abnormal
Show

 ZFA:0000159 tectal ventricle tectal ventricle collapsed , abnormal
Show

 ZFA:0000360 heart tube heart tube bifurcated , abnormal
heart tube duplicated , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0001259 forebrain ventricle forebrain ventricle collapsed , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr