ENSDARG00000042027


Danio rerio

Features
Gene ID: ENSDARG00000042027
  
Biological name :prrx1b
  
Synonyms : paired related homeobox 1b / prrx1b
  
Possible biological names infered from orthology : P54821 / P63013 / Paired mesoderm homeobox protein 1 / paired related homeobox 1 / PRRX1
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 34511678
Gene end: 34521041
  
Corresponding Affymetrix probe sets: Dr.1221.1.A1_at (Zebrafish Array)   NM_200050_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000061587
Ensembl peptide - ENSDARP00000115613
NCBI entrez gene - 337089     See in Manteia.
RefSeq - NM_200050
RefSeq Peptide - NP_956344
swissprot - F1Q7Y7
swissprot - Q6P295
ZFIN ID - ZDB-GENE-030131-9033
Ensembl - ENSDARG00000042027
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRRX1ENSGALG00000003324Gallus gallus
 PRRX1ENSG00000116132Homo sapiens
 Prrx1ENSMUSG00000026586Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prrx1a / paired related homeobox 1a / PRRX1* / P63013* / P54821* / paired related homeobox 1* / Paired mesoderm homeobox protein 1 *ENSDARG0000003397189
pitx2 / Q9W5Z2 / paired-like homeodomain 2 / P97474* / Q99697* / paired-like homeodomain transcription factor 2*ENSDARG0000003619429
pitx3 / Q6QU75 / paired-like homeodomain 3ENSDARG0000007006928
pitx1 / paired-like homeodomain 1 / PITX3* / P78337* / O75364* / paired like homeodomain 3*ENSDARG0000011660827
dmbx1b / Q566X8 / diencephalon/mesencephalon homeobox 1b / DMBX1* / Q8NFW5* / diencephalon/mesencephalon homeobox 1*ENSDARG0000000251026
Q8JI10 / dmbx1a / diencephalon/mesencephalon homeobox 1a / DMBX1* / Q91ZK4* / Q8NFW5* / diencephalon/mesencephalon homeobox 1* / Diencephalon/mesencephalon homeobox protein 1 *ENSDARG0000000992225
otx1 / Q91994 / orthodenticle homeobox 1 / P32242* / P80205* / Homeobox protein OTX1 *ENSDARG0000009499223
otx2b / Q91981 / orthodenticle homeobox 2b / OTX2* / P32243* / orthodenticle homeobox 2*ENSDARG0000001123522
otx2a / Q90267 / orthodenticle homeobox 2aENSDARG0000003070322
otx5 / orthodenticle homolog 5ENSDARG0000004348322
crx / cone-rod homeoboxENSDARG0000001198921
zgc:101100ENSDARG0000002195920
pax10 / paired box 10ENSDARG0000005336419
gsc / goosecoid / P56915* / Q02591* / goosecoid homeobox* / Homeobox protein goosecoid *ENSDARG0000005907319
mixl1 / Mix paired-like homeobox / Q9H2W2* / Q9WUI0* / Homeobox protein MIXL1 *ENSDARG0000006925215


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003654  OAR domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:1904888 cranial skeletal system development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000250 opercle opercle decreased size , abnormal
Show

 ZFA:0000657 entopterygoid entopterygoid absent , abnormal
Show

 ZFA:0000672 hyomandibula hyomandibula morphology , abnormal
hyomandibula fused with inner ear , abnormal
hyomandibula malformed , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage length , ameliorated
Show

 ZFA:0001216 splanchnocranium splanchnocranium shortened , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch ventral region decreased amount , abnormal
Show

 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage morphology , abnormal
palatoquadrate cartilage mislocalised , abnormal
palatoquadrate cartilage fused with inner ear , abnormal
palatoquadrate cartilage fused with neurocranial trabecula , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage size , ameliorated
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage ventral region morphology , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage curved , abnormal
ceratobranchial cartilage shortened , abnormal
Show

 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 postero-dorsal region increased amount , abnormal
pharyngeal arch 2 postero-dorsal region mislocalised , abnormal
pharyngeal arch 2 postero-dorsal region increased distribution , abnormal
pharyngeal arch 2 postero-dorsal region decreased amount , abnormal
pharyngeal arch 2 dorsal margin increased amount , abnormal
pharyngeal arch 2 dorsal margin mislocalised , abnormal
pharyngeal arch 2 dorsal margin increased distribution , abnormal
pharyngeal arch 2 increased distribution , abnormal
Show

 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 dorsal region increased amount , abnormal
pharyngeal arch 1 dorsal region mislocalised , abnormal
pharyngeal arch 1 dorsal region increased distribution , abnormal
Show

 ZFA:0005629 hyomandibular foramen hyomandibular foramen absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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