ENSDARG00000011821


Danio rerio

Features
Gene ID: ENSDARG00000011821
  
Biological name :plod2
  
Synonyms : plod2 / procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
  
Possible biological names infered from orthology : O00469 / Q9R0B9
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 5237709
Gene end: 5314707
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000012147
Ensembl peptide - ENSDARP00000097266
NCBI entrez gene - 100036767     See in Manteia.
RefSeq - NM_001007377
RefSeq - NM_001089464
RefSeq Peptide - NP_001007378
RefSeq Peptide - NP_001082933
swissprot - A4U7F8
swissprot - A4U7F9
ZFIN ID - ZDB-GENE-070326-1
Ensembl - ENSDARG00000011821
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLOD2ENSGALG00000006783Gallus gallus
 PLOD2ENSG00000152952Homo sapiens
 Plod2ENSMUSG00000032374Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
plod3 / wu:fb72h05 / O60568* / Q9R0E1* / procollagen-lysine,2-oxoglutarate 5-dioxygenase 3*ENSDARG0000007631757
plod1a / procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1a / PLOD1* / Q9R0E2* / Q02809* / procollagen-lysine,2-oxoglutarate 5-dioxygenase 1*ENSDARG0000005974656
colgalt2 / collagen beta(1-O)galactosyltransferase 2 / Q6NVG7* / Q8IYK4* / Procollagen galactosyltransferase 2 *ENSDARG0000001467013
A5PMF6 / COLGALT1 / si:ch211-114l13.7 / Q8K297* / Q8NBJ5* / Procollagen galactosyltransferase 1 * / collagen beta(1-O)galactosyltransferase 1*ENSDARG0000005827013
si:ch211-13f8.2 / Q8IYK4* / Q6NVG7* / COLGALT2* / Procollagen galactosyltransferase 2 * / collagen beta(1-O)galactosyltransferase 2*ENSDARG0000007829913
colgalt1 / collagen beta(1-O)galactosyltransferase 1 / Q8K297* / Q8NBJ5* / Procollagen galactosyltransferase 1 *ENSDARG0000007397412
cercam / cerebral endothelial cell adhesion molecule / A3KGW5* / Q5T4B2* / Inactive glycosyltransferase 25 family member 3 *ENSDARG0000007904912


Protein motifs (from Interpro)
Interpro ID Name
 IPR001006  Procollagen-lysine 5-dioxygenase
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008475 procollagen-lysine 5-dioxygenase activity IMP
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000126 centrum centrum decreased length , abnormal
centrum increased thickness , abnormal
centrum malformed , abnormal
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 ZFA:0000135 notochord notochord collagen type I trimer disorganized , abnormal
notochord elastic fiber morphology , abnormal
notochord epithelium proliferative , abnormal
notochord epithelium increased thickness , abnormal
notochord epithelium deformed , abnormal
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 ZFA:0000364 hypural hypural curved , abnormal
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 ZFA:0000438 parhypural parhypural curved , abnormal
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 ZFA:0000519 hemal arch hemal arch morphology , abnormal
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 ZFA:0000538 rib rib curved , abnormal
rib kinked , abnormal
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 ZFA:0000671 horizontal myoseptum horizontal myoseptum skeletal muscle cell dense , abnormal
horizontal myoseptum skeletal muscle cell decreased diameter , abnormal
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 ZFA:0000737 cranium cranium malformed , abnormal
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 ZFA:0001066 neural arch neural arch morphology , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
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 ZFA:0001189 vertebra vertebra morphology , abnormal
vertebra condensed , abnormal
vertebra protruding , abnormal
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 ZFA:0001559 vertebral column vertebral column malformed , abnormal
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 ZFA:0005621 bone tissue bone tissue increased amount , abnormal
bone tissue surrounding notochord , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011821 plod2 / procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 / O00469* / Q9R0B9*  / complex / reaction
 ENSDARG00000059746 plod1a / procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1a / PLOD1* / Q9R0E2* / Q02809* / procollagen-lysine,2-oxoglutarate 5-dioxygenase 1*  / reaction
 ENSDARG00000076317 plod3 / wu:fb72h05 / O60568* / Q9R0E1* / procollagen-lysine,2-oxoglutarate 5-dioxygenase 3*  / reaction






 

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