ENSDARG00000011863


Danio rerio

Features
Gene ID: ENSDARG00000011863
  
Biological name :ptk7a
  
Synonyms : protein tyrosine kinase 7a / ptk7a
  
Possible biological names infered from orthology : Inactive tyrosine-protein kinase 7 / protein tyrosine kinase 7 (inactive) / PTK7 / Q13308 / Q8BKG3
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 38394502
Gene end: 38459454
  
Corresponding Affymetrix probe sets: Dr.9163.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000089232
Ensembl peptide - ENSDARP00000124586
NCBI entrez gene - 553690     See in Manteia.
RefSeq - NM_001020665
RefSeq Peptide - NP_001018501
swissprot - F8W2W3
swissprot - E7F2R9
ZFIN ID - ZDB-GENE-050522-216
Ensembl - ENSDARG00000011863
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTK7ENSGALG00000008609Gallus gallus
 PTK7ENSG00000112655Homo sapiens
 Ptk7ENSMUSG00000023972Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
igf1rb / insulin-like growth factor 1b receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*ENSDARG0000003443415
ros1 / c-ros oncogene 1 , receptor tyrosine kinase / P08922* / Q78DX7* / Proto-onco tyrosine-protein kinase ROS * / ROS proto-oncogene 1, receptor tyrosine kinase*ENSDARG0000008719715
insra / insulin receptor a / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*ENSDARG0000001194814
ntrk2a / neurotrophic tyrosine kinase, receptor, type 2a / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*ENSDARG0000005989714
insrb / insulin receptor b / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*ENSDARG0000007152414
ntrk3b / neurotrophic tyrosine kinase, receptor, type 3b / NTRK3* / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSDARG0000008621414
ntrk2b / neurotrophic tyrosine kinase, receptor, type 2b / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*ENSDARG0000009851114
igf1ra / insulin-like growth factor 1a receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*ENSDARG0000002742313
ltk / leukocyte receptor tyrosine kinase / P08923* / P29376* / Leukocyte tyrosine kinase receptor *ENSDARG0000004286113
ntrk3a / neurotrophic tyrosine kinase, receptor, type 3a / NTRK3* / Q16288* / Q6VNS1* / NT-3 growth factor receptor * / neurotrophic receptor tyrosine kinase 3*ENSDARG0000007722813
ddr1 / discoidin domain receptor tyrosine kinase 1 / Q03146* / Q08345* / Epithelial discoidin domain-containing receptor 1 *ENSDARG0000007852313
ddr2a / discoidin domain receptor tyrosine kinase 2a / DDR2* / Q16832* / Q62371* / Discoidin domain-containing receptor 2 * / discoidin domain receptor tyrosine kinase 2*ENSDARG0000010069313
ddr2l / discoidin domain receptor family, member 2, likeENSDARG0000010383013
ntrk1 / neurotrophic tyrosine kinase, receptor, type 1 / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *ENSDARG0000000458612
ror1 / receptor tyrosine kinase-like orphan receptor 1 / Q01973* / Q9Z139* / Inactive tyrosine-protein kinase transmembrane receptor ROR1 *ENSDARG0000001517612
ddr2b / discoidin domain receptor tyrosine kinase 2b / DDR2* / Q16832* / Q62371* / Discoidin domain-containing receptor 2 * / discoidin domain receptor tyrosine kinase 2*ENSDARG0000005869512
ror2 / receptor tyrosine kinase-like orphan receptor 2 / Q01974* / Q9Z138*ENSDARG0000007622712
alk / ALK receptor tyrosine kinase / P97793* / Q9UM73* / ALK tyrosine kinase receptor *ENSDARG0000009583311
LT631676.1ENSDARG000001117437
musk / muscle, skeletal, receptor tyrosine kinase / Q61006* / O15146* / muscle associated receptor tyrosine kinase* / Muscle, skeletal receptor tyrosine-protein kinase *ENSDARG000000987643


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR033592  Inactive tyrosine-protein kinase 7


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001736 establishment of planar polarity IEA
 biological_processGO:0003402 planar cell polarity pathway involved in axis elongation IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0035282 segmentation IMP
 biological_processGO:0060026 convergent extension IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0090660 cerebrospinal fluid circulation IMP
 biological_processGO:2000040 regulation of planar cell polarity pathway involved in axis elongation IMP
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hydrocephalic , abnormal
brain ventricular system edematous , abnormal
brain ventricular system composition , ameliorated
brain ventricular system volume , ameliorated
Show

 ZFA:0000029 hindbrain hindbrain ependymal cell has fewer parts of type ependymal cell motile cilium, abnormal
hindbrain ependymal cell has number of ependymal cell motile cilium, ameliorated
Show

 ZFA:0000110 fourth ventricle fourth ventricle cerebrospinal fluid circulation decreased process quality , abnormal
fourth ventricle cerebrospinal fluid circulation process quality , ameliorated
Show

 ZFA:0000132 neural plate neural plate medial-lateral axis distended , abnormal
Show

 ZFA:0000155 somite somite morphology , abnormal
somite shape , abnormal
somite size , abnormal
somite fused with somite , abnormal
Show

 ZFA:0001080 sclerotome sclerotome morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism increased width , abnormal
whole organism shortened , abnormal
whole organism anatomical axis curved , abnormal
whole organism anterior-posterior axis condensed , abnormal
Show

 ZFA:0001189 vertebra vertebra cuneate , abnormal
vertebra decreased size , abnormal
vertebra fused with vertebra , abnormal
vertebra decreased amount , abnormal
Show

 ZFA:0001559 vertebral column vertebral column increased curvature , abnormal
vertebral column rotated , abnormal
vertebral column kinked , abnormal
vertebral column asymmetrically curved , abnormal
vertebral column skeletal system morphogenesis decreased process quality , abnormal
vertebral column curvature , ameliorated
vertebral column skeletal system morphogenesis process quality , ameliorated
Show

 ZFA:0009033 ependymal cell ependymal cell motile cilium assembly decreased occurrence , abnormal
ependymal cell motile cilium assembly occurrence , ameliorated
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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