ENSDARG00000034434


Danio rerio

Features
Gene ID: ENSDARG00000034434
  
Biological name :igf1rb
  
Synonyms : igf1rb / insulin-like growth factor 1b receptor
  
Possible biological names infered from orthology : IGF1R / insulin like growth factor 1 receptor / P08069
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 15446229
Gene end: 15610129
  
Corresponding Affymetrix probe sets: Dr.17727.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000046541
swissprot - B0R0Q2
ZFIN ID - ZDB-GENE-020503-2
Ensembl - ENSDARG00000034434
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IGF1RENSGALG00000040651Gallus gallus
 IGF1RENSG00000140443Homo sapiens
 Igf1rENSMUSG00000005533Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
igf1ra / insulin-like growth factor 1a receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*ENSDARG0000002742375
insra / insulin receptor a / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*ENSDARG0000001194853
insrb / insulin receptor b / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*ENSDARG0000007152452
ltk / leukocyte receptor tyrosine kinase / P08923* / P29376* / Leukocyte tyrosine kinase receptor *ENSDARG0000004286115
ntrk1 / neurotrophic tyrosine kinase, receptor, type 1 / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *ENSDARG0000000458614
ntrk3a / neurotrophic tyrosine kinase, receptor, type 3a / NTRK3* / Q16288* / Q6VNS1* / NT-3 growth factor receptor * / neurotrophic receptor tyrosine kinase 3*ENSDARG0000007722814
ntrk2b / neurotrophic tyrosine kinase, receptor, type 2b / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*ENSDARG0000009851114
ddr2a / discoidin domain receptor tyrosine kinase 2a / DDR2* / Q16832* / Q62371* / Discoidin domain-containing receptor 2 * / discoidin domain receptor tyrosine kinase 2*ENSDARG0000010069314
ror1 / receptor tyrosine kinase-like orphan receptor 1 / Q01973* / Q9Z139* / Inactive tyrosine-protein kinase transmembrane receptor ROR1 *ENSDARG0000001517613
ddr2b / discoidin domain receptor tyrosine kinase 2b / DDR2* / Q16832* / Q62371* / Discoidin domain-containing receptor 2 * / discoidin domain receptor tyrosine kinase 2*ENSDARG0000005869513
ntrk2a / neurotrophic tyrosine kinase, receptor, type 2a / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*ENSDARG0000005989713
ntrk3b / neurotrophic tyrosine kinase, receptor, type 3b / NTRK3* / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSDARG0000008621413
alk / ALK receptor tyrosine kinase / P97793* / Q9UM73* / ALK tyrosine kinase receptor *ENSDARG0000009583313
ddr2l / discoidin domain receptor family, member 2, likeENSDARG0000010383013
ror2 / receptor tyrosine kinase-like orphan receptor 2 / Q01974* / Q9Z138*ENSDARG0000007622712
ddr1 / discoidin domain receptor tyrosine kinase 1 / Q03146* / Q08345* / Epithelial discoidin domain-containing receptor 1 *ENSDARG0000007852312
ros1 / c-ros oncogene 1 , receptor tyrosine kinase / P08922* / Q78DX7* / Proto-onco tyrosine-protein kinase ROS * / ROS proto-oncogene 1, receptor tyrosine kinase*ENSDARG0000008719712
ptk7a / protein tyrosine kinase 7a / PTK7* / Q13308* / Q8BKG3* / Inactive tyrosine-protein kinase 7 * / protein tyrosine kinase 7 (inactive)*ENSDARG0000001186311
musk / muscle, skeletal, receptor tyrosine kinase / Q61006* / O15146* / muscle associated receptor tyrosine kinase* / Muscle, skeletal receptor tyrosine-protein kinase *ENSDARG000000987643
LT631676.1ENSDARG000001117431


Protein motifs (from Interpro)
Interpro ID Name
 IPR000494  Receptor L-domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR003961  Fibronectin type III
 IPR006211  Furin-like cysteine-rich domain
 IPR006212  Furin-like repeat
 IPR008266  Tyrosine-protein kinase, active site
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016246  Tyrosine-protein kinase, insulin-like receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003007 heart morphogenesis IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008354 germ cell migration IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0031076 embryonic camera-type eye development IGI
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IDA
 biological_processGO:0048752 semicircular canal morphogenesis IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005520 insulin-like growth factor binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IGI
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0043560 insulin receptor substrate binding IEA


Pathways (from Reactome)
Pathway description
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain apoptotic , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle structure , abnormal
cardiac ventricle hypoplastic , abnormal
cardiac ventricle decreased size , abnormal
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 ZFA:0000028 heart primordium heart primordium left side unfused from heart primordium right side, abnormal
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 ZFA:0000075 spinal cord spinal cord apoptotic , abnormal
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 ZFA:0000107 eye eye aplastic , abnormal
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 ZFA:0000114 heart heart decreased size , abnormal
heart malformed , abnormal
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 ZFA:0000155 somite somite decreased amount , abnormal
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 ZFA:0000217 inner ear inner ear hair cell absent , abnormal
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 ZFA:0000225 lateral crista primordium lateral crista primordium aplastic , abnormal
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 ZFA:0000411 posterior crista primordium posterior crista primordium aplastic , abnormal
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 ZFA:0000468 anterior crista primordium anterior crista primordium aplastic , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
whole organism decreased length , abnormal
whole organism dead , abnormal
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 ZFA:0009116 slow muscle cell slow muscle cell decreased amount , abnormal
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 ZFA:0009117 fast muscle cell fast muscle cell decreased amount , abnormal
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 ZFA:0009243 CaP motoneuron CaP motoneuron axon decreased functionality , abnormal
CaP motoneuron decreased amount , abnormal
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 ZFA:0009288 primordial germ cell primordial germ cell decreased amount , abnormal
primordial germ cell misrouted , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000027423 igf1ra / insulin-like growth factor 1a receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*  / complex
 ENSDARG00000094132 igf1 / insulin-like growth factor 1 / P05017* / P05019* / Insulin-like growth factor I *  / complex / reaction
 ENSDARG00000033307 igf2b / insulin-like growth factor 2b / IGF2* / P01344* / P09535* / insulin like growth factor 2* / Insulin-like growth factor II Insulin-like growth factor II Preptin*  / complex / reaction
 ENSDARG00000034434 igf1rb / insulin-like growth factor 1b receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*  / complex
 ENSDARG00000075282 irs2b / insulin receptor substrate 2b / IRS2* / Irs3* / P81122* / Q9Y4H2* / insulin receptor substrate 2*  / complex / reaction
 ENSDARG00000054087 irs1 / insulin receptor substrate 1 / P35568*  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction






 

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