ENSDARG00000098764


Danio rerio

Features
Gene ID: ENSDARG00000098764
  
Biological name :musk
  
Synonyms : muscle, skeletal, receptor tyrosine kinase / musk
  
Possible biological names infered from orthology : muscle associated receptor tyrosine kinase / Muscle, skeletal receptor tyrosine-protein kinase / O15146 / Q61006
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 13080092
Gene end: 13179077
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000133070
Ensembl peptide - ENSDARP00000141486
Ensembl peptide - ENSDARP00000139846
Ensembl peptide - ENSDARP00000135948
Ensembl peptide - ENSDARP00000132148
NCBI entrez gene - 334526     See in Manteia.
RefSeq - NM_199908
RefSeq Peptide - NP_956202
swissprot - A0A0R4IDI8
swissprot - Q5J1R9
swissprot - Q8JFU3
swissprot - A0A0R4IJJ5
swissprot - A0A0R4IEH7
ZFIN ID - ZDB-GENE-030131-6458
Ensembl - ENSDARG00000098764
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MUSKENSGALG00000015728Gallus gallus
 MUSKENSG00000030304Homo sapiens
 MuskENSMUSG00000057280Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ntrk1 / neurotrophic tyrosine kinase, receptor, type 1 / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *ENSDARG0000000458616
ntrk2a / neurotrophic tyrosine kinase, receptor, type 2a / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*ENSDARG0000005989715
ntrk2b / neurotrophic tyrosine kinase, receptor, type 2b / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*ENSDARG0000009851115
ntrk3a / neurotrophic tyrosine kinase, receptor, type 3a / NTRK3* / Q16288* / Q6VNS1* / NT-3 growth factor receptor * / neurotrophic receptor tyrosine kinase 3*ENSDARG0000007722814
ntrk3b / neurotrophic tyrosine kinase, receptor, type 3b / NTRK3* / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSDARG0000008621413
insra / insulin receptor a / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*ENSDARG0000001194811
ror1 / receptor tyrosine kinase-like orphan receptor 1 / Q01973* / Q9Z139* / Inactive tyrosine-protein kinase transmembrane receptor ROR1 *ENSDARG0000001517611
igf1rb / insulin-like growth factor 1b receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*ENSDARG0000003443411
ror2 / receptor tyrosine kinase-like orphan receptor 2 / Q01974* / Q9Z138*ENSDARG0000007622711
ddr1 / discoidin domain receptor tyrosine kinase 1 / Q03146* / Q08345* / Epithelial discoidin domain-containing receptor 1 *ENSDARG0000007852311
ddr2b / discoidin domain receptor tyrosine kinase 2b / DDR2* / Q16832* / Q62371* / Discoidin domain-containing receptor 2 * / discoidin domain receptor tyrosine kinase 2*ENSDARG0000005869510
insrb / insulin receptor b / INSR* / P06213* / P15208* / insulin receptor* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*ENSDARG0000007152410
ddr2a / discoidin domain receptor tyrosine kinase 2a / DDR2* / Q16832* / Q62371* / Discoidin domain-containing receptor 2 * / discoidin domain receptor tyrosine kinase 2*ENSDARG0000010069310
ddr2l / discoidin domain receptor family, member 2, likeENSDARG0000010383010
ptk7a / protein tyrosine kinase 7a / PTK7* / Q13308* / Q8BKG3* / Inactive tyrosine-protein kinase 7 * / protein tyrosine kinase 7 (inactive)*ENSDARG000000118639
igf1ra / insulin-like growth factor 1a receptor / IGF1R* / P08069* / insulin like growth factor 1 receptor*ENSDARG000000274239
ltk / leukocyte receptor tyrosine kinase / P08923* / P29376* / Leukocyte tyrosine kinase receptor *ENSDARG000000428619
ros1 / c-ros oncogene 1 , receptor tyrosine kinase / P08922* / Q78DX7* / Proto-onco tyrosine-protein kinase ROS * / ROS proto-oncogene 1, receptor tyrosine kinase*ENSDARG000000871978
alk / ALK receptor tyrosine kinase / P97793* / Q9UM73* / ALK tyrosine kinase receptor *ENSDARG000000958336
LT631676.1ENSDARG000001117432


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR013806  Kringle-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR018056  Kringle, conserved site
 IPR020067  Frizzled domain
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030517 negative regulation of axon extension IMP
 biological_processGO:0043113 receptor clustering IMP
 biological_processGO:0051124 synaptic growth at neuromuscular junction IMP
 biological_processGO:0071340 skeletal muscle acetylcholine-gated channel clustering IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000135 notochord notochord undulate , abnormal
Show

 ZFA:0000155 somite somite quality , abnormal
Show

 ZFA:0000610 vertical myoseptum vertical myoseptum increased amount , abnormal
Show

 ZFA:0001056 myotome myotome neuromuscular junction decreased amount , abnormal
myotome extracellular matrix absent , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism immobile , abnormal
whole organism viability , abnormal
whole organism decreased mobility , abnormal
Show

 ZFA:0009063 peripheral neuron peripheral neuron quality , abnormal
Show

 ZFA:0009243 CaP motoneuron CaP motoneuron growth cone malformed , abnormal
Show

 ZFA:0009244 primary motor neuron primary motor neuron axon morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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