ENSDARG00000013076


Danio rerio

Features
Gene ID: ENSDARG00000013076
  
Biological name :bmi1b
  
Synonyms : bmi1b / bmi1 polycomb ring finger oncogene 1b / Q7T3E6
  
Possible biological names infered from orthology : BMI1 / BMI1 proto-oncogene, polycomb ring finger / COMMD3-BMI1 / COMMD3-BMI1 readthrough / P25916 / P35226 / Polycomb complex protein BMI-1
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 21164930
Gene end: 21170517
  
Corresponding Affymetrix probe sets: Dr.26463.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000115422
Ensembl peptide - ENSDARP00000157311
NCBI entrez gene - 394249     See in Manteia.
swissprot - B0UXV8
swissprot - Q7T3E6
ZFIN ID - ZDB-GENE-040116-4
Ensembl - ENSDARG00000013076
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BMI1ENSGALG00000041267Gallus gallus
 BMI1ENSG00000168283Homo sapiens
 COMMD3-BMI1ENSG00000269897Homo sapiens
 Bmi1ENSMUSG00000026739Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
bmi1a / bmi1 polycomb ring finger oncogene 1a / BMI1* / P35226* / P25916* / COMMD3-BMI1* / COMMD3-BMI1 readthrough* / Polycomb complex protein BMI-1 * / BMI1 proto-oncogene, polycomb ring finger*ENSDARG0000000601076
pcgf1 / polycomb group ring finger 1 / Q8R023* / Q9BSM1* / Polycomb group RING finger protein 1 *ENSDARG0000000124926
pcgf5a / B3DK16 / polycomb group ring finger 5a / PCGF5* / Q86SE9* / Q3UK78* / polycomb group ring finger 5* / Polycomb group RING finger protein 5 *ENSDARG0000007100721
Q1JPS1 / pcgf5b / polycomb group ring finger 5b / PCGF5* / Q3UK78* / Q86SE9* / polycomb group ring finger 5* / Polycomb group RING finger protein 5 *ENSDARG0000005238820
pcgf6 / polycomb group ring finger 6 / Q99NA9* / Q9BYE7* / Polycomb group RING finger protein 6 *ENSDARG0000006968120


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR032443  RAWUL domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0021549 cerebellum development IGI
 biological_processGO:0045814 negative regulation of gene expression, epigenetic ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0031519 PcG protein complex ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding ISS


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
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 ZFA:0000100 cerebellum cerebellum decreased volume , abnormal
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 ZFA:0000109 forebrain forebrain decreased volume , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex
 ENSDARG00000037773 rybpa / RING1 and YY1 binding protein a / RYBP* / Q8CCI5* / Q8N488* / RING1 and YY1 binding protein*  / complex
 ENSDARG00000002971 phc1 / polyhomeotic homolog 1 / P78364* / Mus musculus polyhomeotic 1 (Phc1), transcript variant 5, mRNA.*  / complex






 

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