ENSDARG00000052061


Danio rerio

Features
Gene ID: ENSDARG00000052061
  
Biological name :col4a6
  
Synonyms : col4a6 / collagen, type IV, alpha 6
  
Possible biological names infered from orthology : collagen type IV alpha 6 chain / Q14031
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 50920437
Gene end: 51102479
  
Corresponding Affymetrix probe sets: Dr.23814.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000105937
Ensembl peptide - ENSDARP00000143226
Ensembl peptide - ENSDARP00000149593
swissprot - A0A1L1QZU7
swissprot - F1QYN1
ZFIN ID - ZDB-GENE-101001-2
Ensembl - ENSDARG00000052061
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 COL4A6ENSGALG00000008266Gallus gallus
 COL4A6ENSG00000197565Homo sapiens
 Col4a6ENSMUSG00000031273Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
col4a5 / collagen, type IV, alpha 5 (Alport syndrome) / P29400* / collagen, type IV, alpha 5* / collagen type IV alpha 5 chain*ENSDARG0000005206345
col4a2 / collagen, type IV, alpha 2 / P08122* / P08572* / collagen type IV alpha 2 chain* / Collagen alpha-2(IV) chain Canstatin*ENSDARG0000010411045
col4a4 / collagen, type IV, alpha 4 / Q9QZR9* / P53420* / Collagen alpha-4(IV) chain * / collagen type IV alpha 4 chain*ENSDARG0000000283143
col4a1 / collagen, type IV, alpha 1 / P02462* / P02463* / collagen type IV alpha 1 chain* / Collagen alpha-1(IV) chain Arresten*ENSDARG0000005500942
col4a3 / collagen, type IV, alpha 3 / Q01955* / Q9QZS0* / collagen type IV alpha 3 chain* / Collagen alpha-3(IV) chain Tumstatin*ENSDARG0000000339540
col16a1 / collagen, type XVI, alpha 1 / Q8BLX7* / Q07092* / Collagen alpha-1(XVI) chain * / collagen type XVI alpha 1 chain*ENSDARG0000000919428
col19a1 / collagen, type XIX, alpha 1ENSDARG0000007616314
zmp:0000000760ENSDARG0000007474512
si:dkey-117n7.4ENSDARG0000009206410
si:ch211-106n13.3ENSDARG000000526339
col21a1 / collagen, type XXI, alpha 1 / Q96P44* / collagen type XXI alpha 1 chain*ENSDARG000000253208
si:dkey-225n22.4ENSDARG000000772453


Protein motifs (from Interpro)
Interpro ID Name
 IPR001442  Collagen IV, non-collagenous
 IPR008160  Collagen triple helix repeat
 IPR016187  C-type lectin fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0048846 axon extension involved in axon guidance IMP
 biological_processGO:0071711 basement membrane organization IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005604 basement membrane IEA
 molecular_functionGO:0005201 extracellular matrix structural constituent IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Laminin interactions
Non-integrin membrane-ECM interactions
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain basement membrane spatial pattern , abnormal
hindbrain basement membrane irregular spatial pattern , abnormal
hindbrain basement membrane branched , abnormal
hindbrain basement membrane truncated , abnormal
hindbrain basement membrane organization decreased process quality , abnormal
hindbrain dorsal region decreased amount , abnormal
hindbrain epidermal cell decreased amount , abnormal
hindbrain basement membrane bifurcated , abnormal
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 ZFA:0000394 molecular layer corpus cerebelli molecular layer corpus cerebelli malformed , abnormal
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 ZFA:0000445 optic tectum optic tectum basement membrane spatial pattern , abnormal
optic tectum basement membrane irregular spatial pattern , abnormal
optic tectum basement membrane organization decreased process quality , abnormal
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 ZFA:0001691 cerebellar granule cell cerebellar granule cell axon mislocalised , abnormal
cerebellar granule cell axon extension involved in axon guidance decreased process quality , abnormal
cerebellar granule cell axon regeneration decreased process quality , abnormal
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 ZFA:0009070 granule cell granule cell axon decreased length , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell retinal ganglion cell axon guidance decreased process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000052063 col4a5 / collagen, type IV, alpha 5 (Alport syndrome) / P29400* / collagen, type IV, alpha 5* / collagen type IV alpha 5 chain*  / - / complex
 ENSDARG00000052061 col4a6 / collagen, type IV, alpha 6 / Q14031* / collagen type IV alpha 6 chain*  / -
 ENSDARG00000104110 col4a2 / collagen, type IV, alpha 2 / P08122* / P08572* / collagen type IV alpha 2 chain* / Collagen alpha-2(IV) chain Canstatin*  / -






 

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