ENSDARG00000058953


Danio rerio

Features
Gene ID: ENSDARG00000058953
  
Biological name :abcc4
  
Synonyms : abcc4 / ATP-binding cassette, sub-family C (CFTR/MRP), member 4
  
Possible biological names infered from orthology : ATP binding cassette subfamily C member 4 / O15439
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 7322587
Gene end: 7390458
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000065499
swissprot - F1QIK5
ZFIN ID - ZDB-GENE-030616-511
Ensembl - ENSDARG00000058953
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ABCC4ENSGALG00000016896Gallus gallus
 ABCC4ENSG00000125257Homo sapiens
 Abcc4ENSMUSG00000032849Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
abcc3 / ATP-binding cassette, sub-family C (CFTR/MRP), member 3 / O15438* / ATP binding cassette subfamily C member 3*ENSDARG0000009666236
abcc2 / ATP-binding cassette, sub-family C (CFTR/MRP), member 2 / Q92887* / Q8VI47* / ATP binding cassette subfamily C member 2* / Canalicular multispecific organic anion transporter 1 *ENSDARG0000001403135
abcc6b.2 / ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 2ENSDARG0000009490135
abcc1 / ATP-binding cassette, sub-family C (CFTR/MRP), member 1 / O35379* / P33527* / ATP binding cassette subfamily C member 1*ENSDARG0000010471935
abcc6a / ATP-binding cassette, sub-family C (CFTR/MRP), member 6aENSDARG0000001675034
abcc12 / ATP-binding cassette, sub-family C (CFTR/MRP), member 12 / Q96J66* / Q80WJ6* / Q96J65* / ABCC11* / ATP binding cassette subfamily C member 12* / ATP binding cassette subfamily C me...ENSDARG0000001305033
abcc5 / ATP-binding cassette, sub-family C (CFTR/MRP), member 5 / O15440* / Q9R1X5* / ATP binding cassette subfamily C member 5* / Multidrug resistance-associated protein 5 *ENSDARG0000006123333
abcc10 / ATP-binding cassette, sub-family C (CFTR/MRP), member 10ENSDARG0000007798833
cftr / Q1LX78 / cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) / P13569* / P26361* / cystic fibrosis transmembrane conductance regulator*ENSDARG0000004110732
si:ch211-221f10.2ENSDARG0000007654732
abcc8b / ATP-binding cassette, sub-family C (CFTR/MRP), member 8b / ABCC8* / Q09428* / ATP binding cassette subfamily C member 8*ENSDARG0000007700730
abcc9 / ATP-binding cassette, sub-family C (CFTR/MRP), member 9 / O60706* / P70170* / ATP binding cassette subfamily C member 9*ENSDARG0000001598529
abcc8 / ATP-binding cassette, sub-family C (CFTR/MRP), member 8 / Q09428* / ATP binding cassette subfamily C member 8*ENSDARG0000005187929
abcc6b.1 / ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 1ENSDARG0000010540326


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR009147  Cystic fibrosis transmembrane conductance regulator
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030240  Multidrug resistance-associated protein 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0098754 detoxification IMP
 biological_processGO:1902017 regulation of cilium assembly IMP
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015562 efflux transmembrane transporter activity IDA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IBA


Pathways (from Reactome)
Pathway description
Platelet degranulation
ABC-family proteins mediated transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle has fewer parts of type Kupffers vesicle motile cilium, abnormal
Kupffers vesicle detection of nodal flow decreased occurrence , abnormal
Kupffers vesicle motile cilium decreased length , abnormal
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 ZFA:0000008 brain brain hydrocephalic , abnormal
brain ventricular system edematous , abnormal
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 ZFA:0000051 otic vesicle otic vesicle has fewer parts of type otic vesicle cilium, abnormal
otic vesicle has extra parts of type otolith , abnormal
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 ZFA:0000075 spinal cord spinal cord has fewer parts of type ependymal cell cilium, abnormal
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 ZFA:0000114 heart heart bilateral symmetry , abnormal
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 ZFA:0000121 lateral plate mesoderm lateral plate mesoderm bilateral symmetry , abnormal
lateral plate mesoderm determination of left/right asymmetry in lateral mesoderm decreased process quality , abnormal
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 ZFA:0000166 lateral crista lateral crista has fewer parts of type lateral crista kinocilium, abnormal
Show

 ZFA:0001115 trunk trunk curved ventral , abnormal
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 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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