ENSDARG00000041107


Danio rerio

Features
Gene ID: ENSDARG00000041107
  
Biological name :cftr
  
Synonyms : cftr / cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) / Q1LX78
  
Possible biological names infered from orthology : cystic fibrosis transmembrane conductance regulator / P13569 / P26361
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 20677090
Gene end: 20722810
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000060242
NCBI entrez gene - 559080     See in Manteia.
RefSeq - NM_001044883
RefSeq Peptide - NP_001038348
swissprot - Q1LX78
ZFIN ID - ZDB-GENE-050517-20
Ensembl - ENSDARG00000041107
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CFTRENSGALG00000032986Gallus gallus
 CFTRENSG00000001626Homo sapiens
 CftrENSMUSG00000041301Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
abcc4 / ATP-binding cassette, sub-family C (CFTR/MRP), member 4 / O15439* / ATP binding cassette subfamily C member 4*ENSDARG0000005895328
abcc2 / ATP-binding cassette, sub-family C (CFTR/MRP), member 2 / Q92887* / Q8VI47* / ATP binding cassette subfamily C member 2* / Canalicular multispecific organic anion transporter 1 *ENSDARG0000001403125
abcc3 / ATP-binding cassette, sub-family C (CFTR/MRP), member 3 / O15438* / ATP binding cassette subfamily C member 3*ENSDARG0000009666225
abcc1 / ATP-binding cassette, sub-family C (CFTR/MRP), member 1 / O35379* / P33527* / ATP binding cassette subfamily C member 1*ENSDARG0000010471925
abcc6a / ATP-binding cassette, sub-family C (CFTR/MRP), member 6aENSDARG0000001675024
abcc6b.2 / ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 2ENSDARG0000009490124
abcc12 / ATP-binding cassette, sub-family C (CFTR/MRP), member 12 / Q96J66* / Q80WJ6* / Q96J65* / ABCC11* / ATP binding cassette subfamily C member 12* / ATP binding cassette subfamily C me...ENSDARG0000001305023
abcc10 / ATP-binding cassette, sub-family C (CFTR/MRP), member 10ENSDARG0000007798823
abcc5 / ATP-binding cassette, sub-family C (CFTR/MRP), member 5 / O15440* / Q9R1X5* / ATP binding cassette subfamily C member 5* / Multidrug resistance-associated protein 5 *ENSDARG0000006123322
si:ch211-221f10.2ENSDARG0000007654722
abcc8b / ATP-binding cassette, sub-family C (CFTR/MRP), member 8b / ABCC8* / Q09428* / ATP binding cassette subfamily C member 8*ENSDARG0000007700722
abcc9 / ATP-binding cassette, sub-family C (CFTR/MRP), member 9 / O60706* / P70170* / ATP binding cassette subfamily C member 9*ENSDARG0000001598521
abcc8 / ATP-binding cassette, sub-family C (CFTR/MRP), member 8 / Q09428* / ATP binding cassette subfamily C member 8*ENSDARG0000005187921
abcc6b.1 / ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 1ENSDARG0000010540318


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR009147  Cystic fibrosis transmembrane conductance regulator
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR025837  CFTR regulator domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002679 respiratory burst involved in defense response IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0015701 bicarbonate transport ISS
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0035377 transepithelial water transport ISS
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0050891 multicellular organismal water homeostasis ISS
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 biological_processGO:0090022 regulation of neutrophil chemotaxis IMP
 biological_processGO:1902476 chloride transmembrane transport ISS
 biological_processGO:1904322 cellular response to forskolin ISS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISS
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005254 chloride channel activity ISS
 molecular_functionGO:0005260 intracellularly ATP-gated chloride channel activity IBA
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0015106 bicarbonate transmembrane transporter activity ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity ISS
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IBA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
RHO GTPases regulate CFTR trafficking
Ub-specific processing proteases
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle decreased volume , abnormal
Kupffers vesicle unlumenized , abnormal
Kupffers vesicle absent , abnormal
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 ZFA:0000008 brain brain spatial pattern , abnormal
brain right side mislocalised , abnormal
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 ZFA:0000114 heart heart mislocalised , abnormal
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 ZFA:0000123 liver liver mislocalised , abnormal
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 ZFA:0000140 pancreas pancreas morphology , abnormal
pancreas decreased size , abnormal
pancreas degenerate , abnormal
pancreas lacks parts or has fewer parts of type pancreatic acinar cell , abnormal
pancreas neutrophil mislocalised , abnormal
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 ZFA:0001249 exocrine pancreas exocrine pancreas degenerate , abnormal
exocrine pancreas fibrillary , abnormal
exocrine pancreas central region lacks all parts of type pancreatic acinar cell , abnormal
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 ZFA:0001372 pancreatic duct pancreatic duct obstructed , abnormal
pancreatic duct dilated , abnormal
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 ZFA:0005739 pancreatic acinar cell pancreatic acinar cell decreased amount , abnormal
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 ZFA:0005740 pancreatic centroacinar cell pancreatic centroacinar cell decreased amount , abnormal
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 ZFA:0005755 islet islet increased amount , abnormal
islet decreased size , abnormal
islet disorganized , abnormal
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 ZFA:0005756 secondary islet secondary islet cell decreased amount , abnormal
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 ZFA:0009327 neutrophil neutrophil decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000025953 rhoq / ras homolog family member Q / P17081* / Q8R527* / Rho-related GTP-binding protein RhoQ *  / complex / reaction
 ENSDARG00000023117 gopc / golgi-associated PDZ and coiled-coil motif containing / Q8BH60* / Q9HD26* / AL132671.2*  / complex
 ENSDARG00000041107 cftr / Q1LX78 / cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) / P13569* / P26361* / cystic fibrosis transmembrane conductance regulator*  / complex
 ENSDARG00000103422 usp10 / ubiquitin specific peptidase 10 / P52479* / Q14694*  / complex






 

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