ENSGALG00000032986


Gallus gallus

Features
Gene ID: ENSGALG00000032986
  
Biological name :CFTR
  
Synonyms : CFTR / cystic fibrosis transmembrane conductance regulator
  
Possible biological names infered from orthology : P13569 / P26361
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 24554513
Gene end: 24638605
  
Corresponding Affymetrix probe sets: GgaAffx.5878.4.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050160
Ensembl peptide - ENSGALP00000057797
Ensembl peptide - ENSGALP00000057058
NCBI entrez gene - 100049619     See in Manteia.
RefSeq - NM_001105666
RefSeq - XM_015275972
RefSeq Peptide - NP_001099136
swissprot - A0A1D5PXU9
swissprot - A0A1D5PVT1
swissprot - A0A1D5PBN0
Ensembl - ENSGALG00000032986
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cftrENSDARG00000041107Danio rerio
 CFTRENSG00000001626Homo sapiens
 CftrENSMUSG00000041301Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ABCC4 / ATP binding cassette subfamily C member 4 / O15439* / ATP-binding cassette, sub-family C (CFTR/MRP), member 4*ENSGALG0000001689631
ABCC1 / multidrug resistance-associated protein 1 / O35379* / P33527* / ATP binding cassette subfamily C member 1* / ATP-binding cassette, sub-family C (CFTR/MRP), member 1*ENSGALG0000000664625
ABCC2 / ATP binding cassette subfamily C member 2 / Q8VI47* / Q92887* / Canalicular multispecific organic anion transporter 1 *ENSGALG0000000739525
ABCC3 / ATP binding cassette subfamily C member 3 / O15438*ENSGALG0000000752224
ENSGALG0000001567524
ABCC5 / ATP binding cassette subfamily C member 5 / O15440* / Q9R1X5* / Multidrug resistance-associated protein 5 *ENSGALG0000000836923
ABCC9 / ATP binding cassette subfamily C member 9 / O60706* / P70170* / ATP-binding cassette, sub-family C (CFTR/MRP), member 9*ENSGALG0000001324423
ABCC8 / ATP binding cassette subfamily C member 8 / Q09428*ENSGALG0000000617222
ABCC6ENSGALG0000003815222


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR009147  Cystic fibrosis transmembrane conductance regulator
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR025837  CFTR regulator domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006695 cholesterol biosynthetic process IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0006904 vesicle docking involved in exocytosis IEA
 biological_processGO:0015701 bicarbonate transport IEA
 biological_processGO:0030301 cholesterol transport IEA
 biological_processGO:0035377 transepithelial water transport IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0045921 positive regulation of exocytosis IEA
 biological_processGO:0048240 sperm capacitation IEA
 biological_processGO:0050891 multicellular organismal water homeostasis IEA
 biological_processGO:0051454 intracellular pH elevation IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060081 membrane hyperpolarization IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 biological_processGO:1902943 positive regulation of voltage-gated chloride channel activity IEA
 biological_processGO:1904322 cellular response to forskolin IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031205 endoplasmic reticulum Sec complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0005260 intracellularly ATP-gated chloride channel activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015106 bicarbonate transmembrane transporter activity IEA
 molecular_functionGO:0015108 chloride transmembrane transporter activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0019869 chloride channel inhibitor activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
RHO GTPases regulate CFTR trafficking
Ub-specific processing proteases
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000014902 GOPC* / Q8BH60* / Q9HD26* / AL132671.2* / golgi associated PDZ and coiled-coil motif containing*  / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000032986 CFTR / cystic fibrosis transmembrane conductance regulator / P13569* / P26361*  / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr