ENSDARG00000104973


Danio rerio

Features
Gene ID: ENSDARG00000104973
  
Biological name :wnt5a
  
Synonyms : wingless-type MMTV integration site family, member 5a / wnt5a
  
Possible biological names infered from orthology : P22725 / P41221 / Wnt family member 5A
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 53670395
Gene end: 53680653
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000137200
swissprot - F1Q8M2
ZFIN ID - ZDB-GENE-060328-3
Ensembl - ENSDARG00000104973
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 WNT5AENSGALG00000034168Gallus gallus
 WNT5AENSG00000114251Homo sapiens
 Wnt5aENSMUSG00000021994Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
wnt5b / Q92050 / wingless-type MMTV integration site family, member 5b / Q9H1J7* / P22726* / Wnt family member 5B*ENSDARG0000010246471
wnt2ba / wingless-type MMTV integration site family, member 2Ba / WNT2B* / Q93097* / Wnt family member 2B*ENSDARG0000000505045
wnt4a / P47793 / wingless-type MMTV integration site family, member 4a / WNT4* / P56705* / P22724* / Wnt family member 4* / wingless-type MMTV integration site family, member 4*ENSDARG0000007120844
wnt2bb / wingless-type MMTV integration site family, member 2Bb / WNT2B* / Q93097* / O70283* / Wnt family member 2B* / wingless-type MMTV integration site family, member 2B*ENSDARG0000003223443
wnt3a / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*ENSDARG0000005882243
wnt4b / wingless-type MMTV integration site family, member 4bENSDARG0000004015942
wnt3 / wingless-type MMTV integration site family, member 3 / P17553* / P56703* / Wnt family member 3*ENSDARG0000003899041
wnt7bb / wingless-type MMTV integration site family, member 7Bb / WNT7B* / P56706* / P28047* / Wnt family member 7B* / wingless-type MMTV integration site family, member 7B*ENSDARG0000007110741
wnt7ab / wingless-type MMTV integration site family, member 7Ab / WNT7A* / O00755* / Wnt family member 7A*ENSDARG0000000248340
wnt7ba / wingless-type MMTV integration site family, member 7Ba / WNT7B* / P56706* / P28047* / Wnt family member 7B* / wingless-type MMTV integration site family, member 7B*ENSDARG0000002285840
wnt2 / Q92048 / wingless-type MMTV integration site family member 2 / P21552* / P09544* / Wnt family member 2*ENSDARG0000004111740
wnt7aa / wingless-type MMTV integration site family, member 7Aa / WNT7A* / P24383* / O00755* / Wnt family member 7A* / wingless-type MMTV integration site family, member 7A*ENSDARG0000004482740
wnt11r / wingless-type MMTV integration site family, member 11, related / WNT11* / P48615* / O96014* / Wnt family member 11* / wingless-type MMTV integration site family, member 11*ENSDARG0000001479639
wnt1 / P24257 / wingless-type MMTV integration site family, member 1 / P04628* / P04426* / Wnt family member 1*ENSDARG0000005555439
wnt11 / wingless-type MMTV integration site family, member 11ENSDARG0000000425638
wnt6b / wingless-type MMTV integration site family, member 6b / WNT6* / Q9Y6F9* / P22727* / Wnt family member 6* / wingless-type MMTV integration site family, member 6*ENSDARG0000007393537
wnt16 / wingless-type MMTV integration site family, member 16 / Q9QYS1* / Q9UBV4* / Wnt family member 16*ENSDARG0000009497336
wnt6a / wingless-type MMTV integration site family, member 6aENSDARG0000003828335


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR018161  Wnt protein, conserved site
 IPR026538  Wnt-5a protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016055 Wnt signaling pathway IBA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0048793 pronephros development IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IBA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
Ca2+ pathway
PCP/CE pathway
Asymmetric localization of PCP proteins
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct dilated , abnormal
pronephric duct cystic , abnormal
Show

 ZFA:0000151 pronephros pronephros cilium disorganized , abnormal
Show

 ZFA:0001094 whole organism whole organism anatomical axis morphology , abnormal
whole organism anatomical axis decreased length , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
post-vent region increased curvature , abnormal
Show

 ZFA:0001287 renal tubule renal tubule dilated , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus morphology , abnormal
pronephric glomerulus dilated , abnormal
pronephric glomerulus cystic , abnormal
Show

 ZFA:0001634 perichondrium perichondrium edematous , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr