ENSG00000073969


Homo sapiens

Features
Gene ID: ENSG00000073969
  
Biological name :NSF
  
Synonyms : N-ethylmaleimide sensitive factor, vesicle fusing ATPase / NSF / P46459
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.31
Gene start: 46590669
Gene end: 46757464
  
Corresponding Affymetrix probe sets: 1566784_at (Human Genome U133 Plus 2.0 Array)   1566785_x_at (Human Genome U133 Plus 2.0 Array)   202395_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000458184
Ensembl peptide - ENSP00000458221
Ensembl peptide - ENSP00000459646
Ensembl peptide - ENSP00000460152
Ensembl peptide - ENSP00000461448
Ensembl peptide - ENSP00000467779
Ensembl peptide - ENSP00000381293
NCBI entrez gene - 4905     See in Manteia.
OMIM - 601633
RefSeq - NM_006178
RefSeq Peptide - NP_006169
swissprot - P46459
swissprot - I3L0L3
swissprot - I3L0N3
swissprot - I3L2G1
swissprot - I3L338
swissprot - I3L4Q9
swissprot - K7EQD6
Ensembl - ENSG00000073969
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nsfaENSDARG00000007654Danio rerio
 nsfbENSDARG00000038991Danio rerio
 NSFENSGALG00000001055Gallus gallus
 NsfENSMUSG00000034187Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003338  CDC48, N-terminal subdomain
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR004201  CDC48, domain 2
 IPR009010  Aspartate decarboxylase-like domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029067  CDC48 domain 2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001921 positive regulation of receptor recycling IDA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006886 intracellular protein transport IMP
 biological_processGO:0006887 exocytosis TAS
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport ISS
 biological_processGO:0017157 regulation of exocytosis ISS
 biological_processGO:0035494 SNARE complex disassembly ISS
 biological_processGO:0045026 plasma membrane fusion TAS
 biological_processGO:0045732 positive regulation of protein catabolic process IMP
 biological_processGO:0048208 COPII vesicle coating TAS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005795 Golgi stack ISS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0043198 dendritic shaft ISS
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000149 SNARE binding ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity ISS
 molecular_functionGO:0017075 syntaxin-1 binding IEA
 molecular_functionGO:0017137 Rab GTPase binding ISS
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IPI
 molecular_functionGO:0042623 ATPase activity, coupled IEA
 molecular_functionGO:0044877 protein-containing complex binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Trafficking of GluR2-containing AMPA receptors
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
Intra-Golgi traffic
Retrograde transport at the Trans-Golgi-Network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000049245 VAMP3 / Q15836 / vesicle associated membrane protein 3  / complex / reaction
 ENSG00000117533 VAMP4 / O75379 / vesicle associated membrane protein 4  / complex / reaction
 ENSG00000104915 STX10 / O60499 / syntaxin 10  / complex / reaction
 ENSG00000105402 NAPA / P54920 / NSF attachment protein alpha  / complex / reaction
 ENSG00000135823 STX6 / O43752 / syntaxin 6  / complex / reaction
 ENSG00000124222 STX16 / O14662 / syntaxin 16  / complex / reaction
 ENSG00000151532 VTI1A / Q96AJ9 / vesicle transport through interaction with t-SNAREs 1A  / complex / reaction
 ENSG00000106636 YKT6 / O15498 / YKT6 v-SNARE homolog  / complex / reaction
 ENSG00000108587 GOSR1 / O95249 / golgi SNAP receptor complex member 1  / complex / reaction
 ENSG00000108433 GOSR2 / O14653 / golgi SNAP receptor complex member 2  / complex / reaction
 ENSG00000105829 BET1 / O15155 / Bet1 golgi vesicular membrane trafficking protein  / complex / reaction
 ENSG00000113734 BNIP1 / Q12981 / BCL2 interacting protein 1  / complex / reaction
 ENSG00000053501 USE1 / Q9NZ43 / unconventional SNARE in the ER 1  / complex / reaction
 ENSG00000162236 STX5 / Q13190 / syntaxin 5  / complex / reaction
 ENSG00000168818 STX18 / Q9P2W9 / syntaxin 18  / complex / reaction
 ENSG00000092108 SCFD1 / Q8WVM8 / sec1 family domain containing 1  / complex / reaction
 ENSG00000177951 BET1L / Q9NYM9 / Bet1 golgi vesicular membrane trafficking protein like  / complex / reaction
 ENSG00000073969 NSF / P46459 / N-ethylmaleimide sensitive factor, vesicle fusing ATPase  / complex
 ENSG00000265808 O75396 / SEC22B / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)  / complex / reaction






 

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