ENSDARG00000007654


Danio rerio

Features
Gene ID: ENSDARG00000007654
  
Biological name :nsfa
  
Synonyms : N-ethylmaleimide-sensitive factor a / nsfa
  
Possible biological names infered from orthology : N-ethylmaleimide sensitive factor, vesicle fusing ATPase / NSF / P46459 / P46460 / Vesicle-fusing ATPase
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 34766989
Gene end: 34801041
  
Corresponding Affymetrix probe sets: Dr.9155.1.S1_at (Zebrafish Array)   Dr.9155.2.A1_at (Zebrafish Array)   NM_001044328_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000093817
NCBI entrez gene - 368483     See in Manteia.
RefSeq - NM_001044328
RefSeq Peptide - NP_001037793
swissprot - B7ZV62
ZFIN ID - ZDB-GENE-030616-37
Ensembl - ENSDARG00000007654
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NSFENSGALG00000001055Gallus gallus
 NSFENSG00000073969Homo sapiens
 NsfENSMUSG00000034187Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nsfb / N-ethylmaleimide-sensitive factor b / NSF* / P46459* / P46460* / Vesicle-fusing ATPase * / N-ethylmaleimide sensitive factor, vesicle fusing ATPase*ENSDARG0000003899182


Protein motifs (from Interpro)
Interpro ID Name
 IPR003338  CDC48, N-terminal subdomain
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR004201  CDC48, domain 2
 IPR009010  Aspartate decarboxylase-like domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029067  CDC48 domain 2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0014037 Schwann cell differentiation IMP
 biological_processGO:0014044 Schwann cell development IMP
 biological_processGO:0021854 hypothalamus development IMP
 biological_processGO:0045162 clustering of voltage-gated sodium channels IMP
 biological_processGO:0048592 eye morphogenesis IMP
 biological_processGO:0048794 swim bladder development IMP
 biological_processGO:0048914 myelination of anterior lateral line nerve axons IMP
 biological_processGO:0048929 efferent axon development in posterior lateral line nerve IMP
 biological_processGO:0048932 myelination of posterior lateral line nerve axons IMP
 biological_processGO:0048933 afferent axon development in posterior lateral line nerve IMP
 biological_processGO:0051875 pigment granule localization IMP
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Trafficking of GluR2-containing AMPA receptors
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
Intra-Golgi traffic
Retrograde transport at the Trans-Golgi-Network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000076 swim bladder swim bladder collapsed , abnormal
Show

 ZFA:0000152 retina retina apoptotic process increased occurrence , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0001094 whole organism whole organism immobile , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism increased length , abnormal
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 ZFA:0009052 motor neuron motor neuron axon degenerate , abnormal
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 ZFA:0009091 melanocyte melanocyte dispersed , abnormal
Show

 ZFA:0009127 photoreceptor cell photoreceptor cell apoptotic , abnormal
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 ZFA:0009262 retinal cone cell retinal cone cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000034885 bet1 / Bet1 golgi vesicular membrane trafficking protein / O15155* / O35623* / BET1 homolog *  / complex / reaction
 ENSDARG00000020405 napab / N-ethylmaleimide-sensitive factor attachment protein, alpha b / NAPA* / Q9DB05* / P54920* / NSF attachment protein alpha* / Alpha-soluble NSF attachment protein *  / complex / reaction
 ENSDARG00000025033 stx5a / syntaxin 5A / STX5* / Q8K1E0* / Q13190* / syntaxin 5*  / complex / reaction
 ENSDARG00000035763 stx18 / Q4VBI7 / syntaxin 18 / Q9P2W9*  / complex / reaction
 ENSDARG00000032037 bet1l / Q68EL3 / Bet1 golgi vesicular membrane trafficking protein-like / Q9NYM9* / O35153* / Gm45785* / BET1-like protein *  / complex / reaction
 ENSDARG00000038991 nsfb / N-ethylmaleimide-sensitive factor b / NSF* / P46459* / P46460* / Vesicle-fusing ATPase * / N-ethylmaleimide sensitive factor, vesicle fusing ATPase*  / complex
 ENSDARG00000053070 gosr2 / golgi SNAP receptor complex member 2 / O14653* / O35166* / AC005670.2*  / complex / reaction
 ENSDARG00000043510 vamp4 / vesicle-associated membrane protein 4 / O70480* / O75379*  / complex / reaction
 ENSDARG00000042742 stx6 / syntaxin 6 / O43752*  / complex / reaction
 ENSDARG00000045065 vti1a / vesicle transport through interaction with t-SNAREs 1A / O89116* / Q96AJ9*  / complex / reaction
 ENSDARG00000007654 nsfa / N-ethylmaleimide-sensitive factor a / NSF* / P46459* / P46460* / Vesicle-fusing ATPase * / N-ethylmaleimide sensitive factor, vesicle fusing ATPase*  / complex
 ENSDARG00000075030 stx10 / syntaxin 10 / O60499*  / complex / reaction
 ENSDARG00000026654 gosr1 / golgi SNAP receptor complex member 1 / O88630* / O95249*  / complex / reaction
 ENSDARG00000078259 bnip1a / BCL2 interacting protein 1a / BNIP1* / Q6QD59* / Q12981* / BCL2 interacting protein 1* / Vesicle transport protein SEC20 *  / reaction / complex
 ENSDARG00000070161 vamp3 / vesicle-associated membrane protein 3 (cellubrevin) / P63024* / Q15836* / vesicle associated membrane protein 3*  / complex / reaction
 ENSDARG00000003307 stx16 / syntaxin 16 / Q8BVI5* / O14662* / STX16-NPEPL1* / STX16-NPEPL1 readthrough (NMD candidate)*  / complex / reaction
 ENSDARG00000100435 Q7SXP0 / sec22bb / SEC22 homolog B, vesicle trafficking protein b / SEC22B* / O08547* / O75396* / Vesicle-trafficking protein SEC22b * / SEC22 homolog B, vesicle trafficking protein (gene/p...  / reaction / complex
 ENSDARG00000104280 bnip1b / BCL2 interacting protein 1b / BNIP1* / Q12981* / BCL2 interacting protein 1*  / reaction / complex






 

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