Manteia

ENSG00000211949

Homo sapiens

Features

Gene ID:	ENSG00000211949

Biological name :	IGHV3-23

Synonyms :	IGHV3-23 / immunoglobulin heavy variable 3-23 / P01764

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	14
Strand:	-1
Band:	q32.33
Gene start:	106268606
Gene end:	106269140

Corresponding Affymetrix probe sets:	211650_x_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000375018 swissprot - P01764 Ensembl - ENSG00000211949

See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ighv14-1	ENSDARG00000096418	Danio rerio

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
IGHV3-66 / A0A0C4DH42 / immunoglobulin heavy variable 3-66	ENSG00000211972	91
IGHV3-64 / A0A075B6Q5 / immunoglobulin heavy variable 3-64	ENSG00000223648	91
IGHV3-64D / A0A0J9YX35 / immunoglobulin heavy variable 3-64D	ENSG00000282639	91
P01767 / IGHV3-53 / immunoglobulin heavy variable 3-53	ENSG00000211967	90
IGHV3-74 / A0A0B4J1X5 / immunoglobulin heavy variable 3-74	ENSG00000224650	90
IGHV3-43 / A0A0B4J1X8 / immunoglobulin heavy variable 3-43	ENSG00000232216	89
IGHV3OR16-10 / immunoglobulin heavy variable 3/OR16-10 (non-functional)	ENSG00000233732	89
P01763 / IGHV3-48 / immunoglobulin heavy variable 3-48	ENSG00000211964	88
P01768 / P0DP03 / IGHV3-30 / immunoglobulin heavy variable 3-30	ENSG00000270550	87
P01780 / IGHV3-7 / immunoglobulin heavy variable 3-7	ENSG00000211938	86
P01762 / IGHV3-11 / immunoglobulin heavy variable 3-11 (gene/pseudogene)	ENSG00000211941	86
IGHV3-21 / A0A0B4J1V1 / immunoglobulin heavy variable 3-21	ENSG00000211947	86
IGHV3-38 / immunoglobulin heavy variable 3-38 (non-functional)	ENSG00000211958	86
IGHV3OR16-13 / immunoglobulin heavy variable 3/OR16-13 (non-functional)	ENSG00000271178	86
IGHV3-20 / A0A0C4DH32 / immunoglobulin heavy variable 3-20	ENSG00000211946	85
P01772 / IGHV3-33 / immunoglobulin heavy variable 3-33	ENSG00000211955	85
IGHV3-35 / immunoglobulin heavy variable 3-35 (non-functional)	ENSG00000211957	84
IGHV3OR16-8 / immunoglobulin heavy variable 3/OR16-8 (non-functional)	ENSG00000271130	84
P01766 / IGHV3-13 / immunoglobulin heavy variable 3-13	ENSG00000211942	83
IGHV3-15 / A0A0B4J1V0 / immunoglobulin heavy variable 3-15	ENSG00000211943	83

Protein motifs (from Interpro)

Interpro ID

Name

No match

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002250	adaptive immune response	IEA
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0006898	receptor-mediated endocytosis	TAS
biological_process	GO:0006910	phagocytosis, recognition	IBA
biological_process	GO:0006911	phagocytosis, engulfment	IBA
biological_process	GO:0006955	immune response	NAS
biological_process	GO:0006956	complement activation	TAS
biological_process	GO:0006958	complement activation, classical pathway	IBA
biological_process	GO:0030449	regulation of complement activation	TAS
biological_process	GO:0038095	Fc-epsilon receptor signaling pathway	TAS
biological_process	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
biological_process	GO:0042742	defense response to bacterium	IBA
biological_process	GO:0045087	innate immune response	IBA
biological_process	GO:0050776	regulation of immune response	TAS
biological_process	GO:0050853	B cell receptor signaling pathway	IBA
biological_process	GO:0050871	positive regulation of B cell activation	IBA
biological_process	GO:0050900	leukocyte migration	TAS
cellular_component	GO:0005576	extracellular region	TAS
cellular_component	GO:0005615	extracellular space	HDA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0009897	external side of plasma membrane	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0042571	immunoglobulin complex, circulating	IBA
cellular_component	GO:0070062	extracellular exosome	HDA
cellular_component	GO:0072562	blood microparticle	HDA
molecular_function	GO:0003823	antigen binding	IBA
molecular_function	GO:0004252	serine-type endopeptidase activity	TAS
molecular_function	GO:0034987	immunoglobulin receptor binding	IBA

Pathways (from Reactome)

Pathway description

Initial triggering of complement

Classical antibody-mediated complement activation

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Cell surface interactions at the vascular wall

FCGR activation

Regulation of actin dynamics for phagocytic cup formation

Role of phospholipids in phagocytosis

Scavenging of heme from plasma

Fc epsilon receptor (FCERI) signaling

Role of LAT2/NTAL/LAB on calcium mobilization

FCERI mediated MAPK activation

FCERI mediated Ca+2 mobilization

FCERI mediated NF-kB activation

CD22 mediated BCR regulation

Regulation of Complement cascade

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr