ENSG00000211964


Homo sapiens

Features
Gene ID: ENSG00000211964
  
Biological name :IGHV3-48
  
Synonyms : IGHV3-48 / immunoglobulin heavy variable 3-48 / P01763
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q32.33
Gene start: 106537810
Gene end: 106538344
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000375033
swissprot - P01763
Ensembl - ENSG00000211964
  
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ighv14-1ENSDARG00000096418Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGHV3-21 / A0A0B4J1V1 / immunoglobulin heavy variable 3-21ENSG0000021194795
P01780 / IGHV3-7 / immunoglobulin heavy variable 3-7ENSG0000021193891
IGHV3-74 / A0A0B4J1X5 / immunoglobulin heavy variable 3-74ENSG0000022465089
P01762 / IGHV3-11 / immunoglobulin heavy variable 3-11 (gene/pseudogene)ENSG0000021194188
P01764 / IGHV3-23 / immunoglobulin heavy variable 3-23ENSG0000021194988
P01766 / IGHV3-13 / immunoglobulin heavy variable 3-13ENSG0000021194286
P01772 / IGHV3-33 / immunoglobulin heavy variable 3-33ENSG0000021195585
IGHV3-66 / A0A0C4DH42 / immunoglobulin heavy variable 3-66ENSG0000021197285
IGHV3-64 / A0A075B6Q5 / immunoglobulin heavy variable 3-64ENSG0000022364885
IGHV3OR16-10 / immunoglobulin heavy variable 3/OR16-10 (non-functional)ENSG0000023373285
P01768 / P0DP03 / IGHV3-30 / immunoglobulin heavy variable 3-30ENSG0000027055085
IGHV3OR16-13 / immunoglobulin heavy variable 3/OR16-13 (non-functional)ENSG0000027117885
P01767 / IGHV3-53 / immunoglobulin heavy variable 3-53ENSG0000021196784
IGHV3-43 / A0A0B4J1X8 / immunoglobulin heavy variable 3-43ENSG0000023221684
IGHV3-20 / A0A0C4DH32 / immunoglobulin heavy variable 3-20ENSG0000021194683
IGHV3-64D / A0A0J9YX35 / immunoglobulin heavy variable 3-64DENSG0000028263983
IGHV3-35 / immunoglobulin heavy variable 3-35 (non-functional)ENSG0000021195782
IGHV3OR16-8 / immunoglobulin heavy variable 3/OR16-8 (non-functional)ENSG0000027113082
IGHV3-38 / immunoglobulin heavy variable 3-38 (non-functional)ENSG0000021195881
AC136428.1ENSG0000025968080


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0006955 immune response NAS
 biological_processGO:0006956 complement activation TAS
 biological_processGO:0006958 complement activation, classical pathway TAS
 biological_processGO:0030449 regulation of complement activation TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050900 leukocyte migration TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003823 antigen binding NAS
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Classical antibody-mediated complement activation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Scavenging of heme from plasma
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD22 mediated BCR regulation
Regulation of Complement cascade
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr