ENSGALG00000015373


Gallus gallus

Features
Gene ID: ENSGALG00000015373
  
Biological name :PDE6B
  
Synonyms : Gallus gallus phosphodiesterase 6B (PDE6B), mRNA. / PDE6B
  
Possible biological names infered from orthology : P23440 / P35913 / phosphodiesterase 6B / phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 53489854
Gene end: 53511537
  
Corresponding Affymetrix probe sets: Gga.5183.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000051091
Ensembl peptide - ENSGALP00000032161
NCBI entrez gene - 395092     See in Manteia.
RefSeq - XM_015280491
RefSeq - NM_001318440
RefSeq Peptide - NP_001305369
swissprot - A0A1D5PE90
swissprot - F1NA42
Ensembl - ENSGALG00000015373
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde6bENSDARG00000011671Danio rerio
 PDE6BENSG00000133256Homo sapiens
 Pde6bENSMUSG00000029491Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDE6C / cone cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha / P51160* / Q91ZQ1* / phosphodiesterase 6C*ENSGALG0000000662667
PDE5A / Gallus gallus phosphodiesterase 5A (PDE5A), mRNA. / O76074* / Q8CG03* / phosphodiesterase 5A* / cGMP-specific 3,5-cyclic phosphodiesterase *ENSGALG0000001198231
P0C1Q2* / PDE11A* / Q9HCR9* / phosphodiesterase 11A* / Dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A *ENSGALG0000004237431
PDE10A / phosphodiesterase 10A / Q8CA95* / Q9Y233*ENSGALG0000001153724
PDE3B / cGMP-inhibited 3,5-cyclic phosphodiesterase B / Q13370* / phosphodiesterase 3B*ENSGALG0000000603517
PDE3A / phosphodiesterase 3A / Q14432* / Q9Z0X4* / phosphodiesterase 3A, cGMP inhibited*ENSGALG0000001314317
PDE9A / phosphodiesterase 9A / O70628* / O76083* / High affinity cGMP-specific 3,5-cyclic phosphodiesterase 9A *ENSGALG0000001618611


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003018  GAF domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR029016  GAF-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009583 detection of light stimulus IEA
 biological_processGO:0046037 GMP metabolic process IEA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047555 3",5"-cyclic-GMP phosphodiesterase activity IEA


Pathways (from Reactome)
Pathway description
Activation of the phototransduction cascade
Ca2+ pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004514 PDE6G / phosphodiesterase 6G / P09174* / P18545* / phosphodiesterase 6G, cGMP-specific, rod, gamma*  / complex
 ENSGALG00000028697 GNAT1 / G protein subunit alpha transducin 1 / P11488* / P20612* / guanine nucleotide binding protein, alpha transducing 1*  / complex
 ENSGALG00000038084 GNAT2 / G protein subunit alpha transducin 2 / P19087* / P50149* / guanine nucleotide binding protein, alpha transducing 2*  / complex






 

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