ENSGALG00000029533


Gallus gallus
regulationLRP5morphogenesissignalingdevelopmentinvolvedwntcellpathwaybonereceptorprocessactivitymembraneclasslipoproteinproliferationosteoblastbloodtranscriptionmammaryglandrepeatlow-densityldlproteingastrulationvasculatureglucosecholesterolspecification

Features
Gene ID: ENSGALG00000029533
  
Biological name :LRP5
  
Synonyms : low-density lipoprotein receptor-related protein 5 precursor / LRP5
  
Possible biological names infered from orthology : LDL receptor related protein 5 / Low-density lipoprotein receptor-related protein 5 / O75197 / Q91VN0
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 16375981
Gene end: 16504146
  
Corresponding Affymetrix probe sets: Gga.18288.1.S1_s_at (Chicken Array)   GgaAffx.12228.1.S1_at (Chicken Array)   GgaAffx.4334.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000053759
NCBI entrez gene - 423114     See in Manteia.
RefSeq - NM_001012897
RefSeq Peptide - NP_001012915
swissprot - Q5ZKF9
Ensembl - ENSGALG00000029533
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrp5ENSDARG00000006921Danio rerio
 LRP5ENSG00000162337Homo sapiens
 Lrp5ENSMUSG00000024913Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRP6 / LDL receptor related protein 6 / O75581*ENSGALG0000003150372
LRP4 / LDL receptor related protein 4 / O75096* / Q8VI56* / Low-density lipoprotein receptor-related protein 4 *ENSGALG0000003218136
LRP2 / LDL receptor related protein 2 / A2ARV4* / P98164* / low density lipoprotein receptor-related protein 2*ENSGALG0000001085834
LRP1B / LDL receptor related protein 1B / Q9NZR2*ENSGALG0000001240732
VLDLR / P98165 / Very low-density lipoprotein receptor / P98155* / P98156*ENSGALG000000101669
LRP8 / low-density lipoprotein receptor-related protein 8 precursor / Q14114* / Q924X6* / LDL receptor related protein 8* / Low-density lipoprotein receptor-related protein 8 *ENSGALG000000106929
Gm19410*ENSGALG000000231726


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000742  EGF-like domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR017049  Low density lipoprotein receptor-related protein 5/6
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site


Gene Ontology (GO)
anatomical structure developmentmesenchymal cell proliferationcellular developmental processossificationcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processregulation of biological qualitysystem processcell communicationcellular response to stimulusosteoblast proliferationmaintenance of cell numberlocalization of cellmovement of cell or subcellular componentcell deathcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processtissue remodelingregulation of molecular functionmacromolecule localizationresponse to chemicalestablishment of localizationcellular localizationanatomical structure developmentmesenchymal cell proliferationcellular developmental processossificationcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processregulation of biological qualitysystem processcell communicationcellular response to stimulusosteoblast proliferationmaintenance of cell numberlocalization of cellmovement of cell or subcellular componentcell deathcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processtissue remodelingregulation of molecular functionmacromolecule localizationresponse to chemicalestablishment of localizationcellular localizationanatomical structure developmentmesenchymal cell proliferationcellular developmental processossificationcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processregulation of biological qualitysystem processcell communicationcellular response to stimulusosteoblast proliferationmaintenance of cell numberlocalization of cellmovement of cell or subcellular componentcell deathcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processtissue remodelingregulation of molecular functionmacromolecule localizationresponse to chemicalestablishment of localizationcellular localizationanatomical structure developmentmesenchymal cell proliferationcellular developmental processossificationcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processregulation of biological qualitysystem processcell communicationcellular response to stimulusosteoblast proliferationmaintenance of cell numberlocalization of cellmovement of cell or subcellular componentcell deathcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processtissue remodelingregulation of molecular functionmacromolecule localizationresponse to chemicalestablishment of localizationcellular localizationanatomical structure developmentmesenchymal cell proliferationcellular developmental processossificationcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processregulation of biological qualitysystem processcell communicationcellular response to stimulusosteoblast proliferationmaintenance of cell numberlocalization of cellmovement of cell or subcellular componentcell deathcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processtissue remodelingregulation of molecular functionmacromolecule localizationresponse to chemicalestablishment of localizationcellular localizationanatomical structure developmentmesenchymal cell proliferationcellular developmental processossificationcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processregulation of biological qualitysystem processcell communicationcellular response to stimulusosteoblast proliferationmaintenance of cell numberlocalization of cellmovement of cell or subcellular componentcell deathcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processtissue remodelingregulation of molecular functionmacromolecule localizationresponse to chemicalestablishment of localizationcellular localizationanatomical structure developmentmesenchymal cell proliferationcellular developmental processossificationcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processregulation of biological qualitysystem processcell communicationcellular response to stimulusosteoblast proliferationmaintenance of cell numberlocalization of cellmovement of cell or subcellular componentcell deathcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processtissue remodelingregulation of molecular functionmacromolecule localizationresponse to chemicalestablishment of localizationcellular localizationanatomical structure developmentmesenchymal cell proliferationcellular developmental processossificationcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processregulation of biological qualitysystem processcell communicationcellular response to stimulusosteoblast proliferationmaintenance of cell numberlocalization of cellmovement of cell or subcellular componentcell deathcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processtissue remodelingregulation of molecular functionmacromolecule localizationresponse to chemicalestablishment of localizationcellular localizationanatomical structure developmentmesenchymal cell proliferationcellular developmental processossificationcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processregulation of biological qualitysystem processcell communicationcellular response to stimulusosteoblast proliferationmaintenance of cell numberlocalization of cellmovement of cell or subcellular componentcell deathcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processtissue remodelingregulation of molecular functionmacromolecule localizationresponse to chemicalestablishment of localizationcellular localizationanatomical structure developmentmesenchymal cell proliferationcellular developmental processossificationcatabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processregulation of biological qualitysystem processcell communicationcellular response to stimulusosteoblast proliferationmaintenance of cell numberlocalization of cellmovement of cell or subcellular componentcell deathcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processtissue remodelingregulation of molecular functionmacromolecule localizationresponse to chemicalestablishment of localizationcellular localizationanatoanatomical structure developmentmesenmesenchymal cell proliferationcellucellular developmental processossifossificationcatabcatabolic processprimaprimary metabolic processsmallsmall molecule metabolic processorganorganic substance metabolic processregulregulation of biological qualitysystesystem processcell cell communicationcellucellular response to stimulusosteoosteoblast proliferationmaintmaintenance of cell numberlocallocalization of cellmovemmovement of cell or subcellular componentcell cell deathcellucellular component organizationcell cell cyclenitronitrogen compound metabolic processbiosybiosynthetic processcellucellular metabolic processtissutissue remodelingregulregulation of molecular functionmacromacromolecule localizationresporesponse to chemicalestabestablishment of localizationcellucellular localization
protein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingprotein bindingsignaling receptor activitysignaling receptor activity
cellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellcellorganelleorganellemembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0001702 gastrulation with mouth forming second IEA
 biological_processGO:0001944 vasculature development IEA
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IEA
 biological_processGO:0002076 osteoblast development IEA
 biological_processGO:0006007 glucose catabolic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0033690 positive regulation of osteoblast proliferation IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0035108 limb morphogenesis IEA
 biological_processGO:0035426 extracellular matrix-cell signaling IEA
 biological_processGO:0042074 cell migration involved in gastrulation IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046849 bone remodeling IEA
 biological_processGO:0046850 regulation of bone remodeling IEA
 biological_processGO:0048539 bone marrow development IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0060033 anatomical structure regression IEA
 biological_processGO:0060042 retina morphogenesis in camera-type eye IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0060349 bone morphogenesis IEA
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IEA
 biological_processGO:0060603 mammary gland duct morphogenesis IEA
 biological_processGO:0060612 adipose tissue development IEA
 biological_processGO:0060764 cell-cell signaling involved in mammary gland development IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0061299 retina vasculature morphogenesis in camera-type eye IEA
 biological_processGO:0061304 retinal blood vessel morphogenesis IEA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:1902262 apoptotic process involved in blood vessel morphogenesis IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0042813 Wnt-activated receptor activity IEA
 molecular_functionGO:0071936 coreceptor activity involved in Wnt signaling pathway IEA


Pathways (from Reactome)
Pathway description
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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