ENSGALG00000034983


Gallus gallus
cellCDX2regulationdevelopmentdomainrnapolymeraseiidifferentiationdnabindinghomeoboxsequence-specificactivitypatternspecificationmaintenanceepithelialtranscriptionalrepressorhelix-turn-helixmotifcaudal-likeactivationhomeobox-likesuperfamilyconservedsitemetazoablood

Features
Gene ID: ENSGALG00000034983
  
Biological name :CDX2
  
Synonyms : CDX2 / homeobox protein CDX-2
  
Possible biological names infered from orthology : caudal type homeobox 2 / P43241 / Q99626
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 176067483
Gene end: 176070939
  
Corresponding Affymetrix probe sets: Gga.967.1.S1_at (Chicken Array)   GgaAffx.10949.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045645
Ensembl peptide - ENSGALP00000051859
NCBI entrez gene - 374205     See in Manteia.
RefSeq - NM_204311
RefSeq Peptide - NP_989642
swissprot - A0A1D5PGD8
swissprot - A0A1D5NZ33
Ensembl - ENSGALG00000034983
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDX2ENSG00000165556Homo sapiens
 Cdx2ENSMUSG00000029646Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDX1 / Q9DEB6 / Homeobox protein CDX-1 / P18111* / P47902* / caudal type homeobox 1*ENSGALG0000000567947
CDX4 / O14627* / Q07424* / caudal type homeobox 4* / Homeobox protein CDX-4 *ENSGALG0000000765745
CDX4* / O14627* / Q07424* / caudal type homeobox 4* / Homeobox protein CDX-4 *ENSGALG0000000765644
HOXA4 / P17277 / Homeobox protein Hox-A4 / Q00056* / homeobox A4*ENSGALG0000002262222
HOXB5ENSGALG0000003490722
HOXB4 / P14840 / Homeobox protein Hox-B4 / P10284* / P17483* / homeobox B4*ENSGALG0000000028421
HOXA5 / Q6B3N0 / Homeobox protein Hox-A5 / P09021* / P20719* / homeobox A5*ENSGALG0000002592921
HOXC4 / homeobox C4 / P09017* / Q08624*ENSGALG0000003553921
HOXD4 / homeobox D4 / P09016* / P10628* / Homeobox protein Hox-D4 *ENSGALG0000002341920
HOXA7 / Q90VZ9 / Homeobox protein Hox-A7 / P02830* / P31268* / homeobox A7*ENSGALG0000002698919
HOXC5* / Q00444* / P32043* / AC012531.3* / homeobox C5* / Homeobox protein Hox-C5 *ENSGALG0000003041619
HOXB8 / homeobox B8 / P09632* / P17481* / Homeobox protein Hox-B8 *ENSGALG0000004032019
HOXA6 / Q5YLH5 / Homeobox protein Hox-A6 ENSGALG0000002890818
HOXC8 / Q9YH13 / Homeobox protein Hox-C8 / P09025* / P31273* / homeobox C8*ENSGALG0000003726218
HOXA6* / HOXB6* / P09023* / P09092* / P17509* / P31267* / homeobox B6* / homeobox A6* / Homeobox protein Hox-B6 * / Homeobox protein Hox-A6 *ENSGALG0000003761918
HOXC6 / homeobox C6 / P09630* / P10629* / Homeobox protein Hox-C6 *ENSGALG0000003905118
HOXB7 / homeobox B7 / P09024* / P09629* / Homeobox protein Hox-B7 *ENSGALG0000003274017
HOXD8 / P23459 / Homeobox protein Hox-D8 / P13378* / P23463* / homeobox D8*ENSGALG0000003727216


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR006820  Caudal-like activation domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processestablishment of localizationcellular localizationmaintenance of cell numberestablishment or maintenance of cell polaritynitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processestablishment of localizationcellular localizationmaintenance of cell numberestablishment or maintenance of cell polaritynitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processestablishment of localizationcellular localizationmaintenance of cell numberestablishment or maintenance of cell polaritynitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processestablishment of localizationcellular localizationmaintenance of cell numberestablishment or maintenance of cell polaritynitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processestablishment of localizationcellular localizationmaintenance of cell numberestablishment or maintenance of cell polaritynitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processestablishment of localizationcellular localizationmaintenance of cell numberestablishment or maintenance of cell polaritynitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processestablishment of localizationcellular localizationmaintenance of cell numberestablishment or maintenance of cell polaritynitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processestablishment of localizationcellular localizationmaintenance of cell numberestablishment or maintenance of cell polaritynitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processestablishment of localizationcellular localizationmaintenance of cell numberestablishment or maintenance of cell polaritynitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processestablishment of localizationcellular localizationmaintenance of cell numberestablishment or maintenance of cell polaritynitrogen comnitrogen compound metabolic processbiosyntheticbiosynthetic processcellular metcellular metabolic processprimary metaprimary metabolic processorganic subsorganic substance metabolic processanatomical sanatomical structure developmentcellular devcellular developmental processestablishmenestablishment of localizationcellular loccellular localizationmaintenance maintenance of cell numberestablishmenestablishment or maintenance of cell polarity
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor acDNA-binding transcription factor activitytranscription coregulator activitytranscription coregulator activity
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001824 blastocyst development IEA
 biological_processGO:0001829 trophectodermal cell differentiation IEA
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0008333 endosome to lysosome transport IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0014807 regulation of somitogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0060575 intestinal epithelial cell differentiation IEA
 biological_processGO:0060711 labyrinthine layer development IEA
 cellular_componentGO:0000794 condensed nuclear chromosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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