ENSMUSG00000024013


Mus musculus

Features
Gene ID: ENSMUSG00000024013
  
Biological name :Fgd2
  
Synonyms : Fgd2 / FYVE, RhoGEF and PH domain-containing protein 2 / Q8BY35
  
Possible biological names infered from orthology : FYVE, RhoGEF and PH domain containing 2 / Q7Z6J4
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 29360914
Gene end: 29379660
  
Corresponding Affymetrix probe sets: 10443506 (MoGene1.0st)   1419515_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024810
Ensembl peptide - ENSMUSP00000118828
NCBI entrez gene - 26382     See in Manteia.
MGI - MGI:1347084
RefSeq - XM_017317478
RefSeq - NM_001159538
RefSeq - NM_013710
RefSeq - XM_006524300
RefSeq - XM_006524303
RefSeq - XM_011246472
RefSeq - XM_011246473
RefSeq - XM_006524299
RefSeq Peptide - NP_001153010
RefSeq Peptide - NP_038738
swissprot - Q8BY35
swissprot - E9PVB8
Ensembl - ENSMUSG00000024013
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGD2ENSG00000146192Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgd4 / Q91ZT5 / FYVE, RhoGEF and PH domain-containing protein 4 / Q96M96* / FYVE, RhoGEF and PH domain containing 4*ENSMUSG0000002278846
Fgd1 / P52734 / FYVE, RhoGEF and PH domain-containing protein 1 / P98174* / FYVE, RhoGEF and PH domain containing 1*ENSMUSG0000002526546
Fgd3 / FYVE, RhoGEF and PH domain containing 3 / Q5JSP0*ENSMUSG0000003794637
Fgd6 / Q69ZL1 / FYVE, RhoGEF and PH domain-containing protein 6 / Q6ZV73* / FYVE, RhoGEF and PH domain containing 6*ENSMUSG0000002002126
Fgd5 / FYVE, RhoGEF and PH domain containing 5 / Q6ZNL6*ENSMUSG0000003403724
Q91WB4 / Plekhf2 / Pleckstrin homology domain-containing family F member 2 / Q9H8W4* / pleckstrin homology and FYVE domain containing 2*ENSMUSG0000004996910
Q3TB82 / Plekhf1 / Pleckstrin homology domain-containing family F member 1 / Q96S99* / pleckstrin homology and FYVE domain containing 1*ENSMUSG0000007417010


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000306  FYVE zinc finger
 IPR001849  Pleckstrin homology domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR011993  PH-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017455  Zinc finger, FYVE-related
 IPR035899  Dbl homology (DH) domain superfamily
 IPR035941  FGD1-4, C-terminal PH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IGI
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1901981 phosphatidylinositol phosphate binding IDA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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