ENSMUSG00000025265


Mus musculus

Features
Gene ID: ENSMUSG00000025265
  
Biological name :Fgd1
  
Synonyms : Fgd1 / FYVE, RhoGEF and PH domain-containing protein 1 / P52734
  
Possible biological names infered from orthology : FYVE, RhoGEF and PH domain containing 1 / P98174
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F3
Gene start: 151046150
Gene end: 151089521
  
Corresponding Affymetrix probe sets: 10602401 (MoGene1.0st)   1416865_at (Mouse Genome 430 2.0 Array)   1437369_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108305
Ensembl peptide - ENSMUSP00000026296
NCBI entrez gene - 14163     See in Manteia.
MGI - MGI:104566
RefSeq - NM_008001
RefSeq - XM_006528699
RefSeq Peptide - NP_032027
swissprot - A2ALP5
swissprot - P52734
Ensembl - ENSMUSG00000025265
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgd1ENSDARG00000100402Danio rerio
 FGD1ENSG00000102302Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgd4 / Q91ZT5 / FYVE, RhoGEF and PH domain-containing protein 4 / Q96M96* / FYVE, RhoGEF and PH domain containing 4*ENSMUSG0000002278836
Fgd3 / FYVE, RhoGEF and PH domain containing 3 / Q5JSP0*ENSMUSG0000003794636
Fgd2 / Q8BY35 / FYVE, RhoGEF and PH domain-containing protein 2 / Q7Z6J4* / FYVE, RhoGEF and PH domain containing 2*ENSMUSG0000002401331
Fgd6 / Q69ZL1 / FYVE, RhoGEF and PH domain-containing protein 6 / Q6ZV73* / FYVE, RhoGEF and PH domain containing 6*ENSMUSG0000002002124
Fgd5 / FYVE, RhoGEF and PH domain containing 5 / Q6ZNL6*ENSMUSG0000003403721
Q91WB4 / Plekhf2 / Pleckstrin homology domain-containing family F member 2 / Q9H8W4* / pleckstrin homology and FYVE domain containing 2*ENSMUSG000000499697
Q3TB82 / Plekhf1 / Pleckstrin homology domain-containing family F member 1 / Q96S99* / pleckstrin homology and FYVE domain containing 1*ENSMUSG000000741707


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000306  FYVE zinc finger
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017455  Zinc finger, FYVE-related
 IPR035899  Dbl homology (DH) domain superfamily
 IPR035939  FGD1, N-terminal PH domain
 IPR035941  FGD1-4, C-terminal PH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IDA
 biological_processGO:0008360 regulation of cell shape IDA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0046847 filopodium assembly IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031267 small GTPase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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